Continuous and intermittent exposure to ethanol: effect on NG 108-15 cell membrane phospholipids
(1991) In Alcohol and alcoholism. Supplement 1. p.227-231- Abstract
- The effect of continuous and intermittent ethanol exposure on the phospholipid composition of Neuroblastoma x Glioma (NG 108-15) cell membranes was investigated. The cells were treated with ethanol for three weeks. Continuous ethanol exposure (150 mM) produced an increase (27%) in the amount of phosphatidylcholine, whereas intermittent ethanol treatment (150 mM) induced a 22% reduction of this lipid. Decreases of phosphatidylethanolamine plasmalogen (8.5%), phosphatidylinositol (16%) and phosphatidylserine (24%) were also seen after intermittent exposure. After binge administration, the concentration of total phospholipids was reduced by 17%, whereas continuous exposure produced a 19% increase. Both intermittent and continuous exposure... (More)
- The effect of continuous and intermittent ethanol exposure on the phospholipid composition of Neuroblastoma x Glioma (NG 108-15) cell membranes was investigated. The cells were treated with ethanol for three weeks. Continuous ethanol exposure (150 mM) produced an increase (27%) in the amount of phosphatidylcholine, whereas intermittent ethanol treatment (150 mM) induced a 22% reduction of this lipid. Decreases of phosphatidylethanolamine plasmalogen (8.5%), phosphatidylinositol (16%) and phosphatidylserine (24%) were also seen after intermittent exposure. After binge administration, the concentration of total phospholipids was reduced by 17%, whereas continuous exposure produced a 19% increase. Both intermittent and continuous exposure induced a reduction in the total protein content. No changes in phosphatidic acid, sphingomyelin, phosphatidylcholine plasmalogen or phosphatidylethanolamine (diacyl form) were detected with either treatment. The importance of this study is that ethanol, irrespective of amount, can elicit different effects depending on the pattern of administration. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1106005
- author
- Alling, Christer LU ; Rodriguez, F D ; Gustavsson, L and Simonsson, Per LU
- organization
- publishing date
- 1991
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Alcohol and alcoholism. Supplement
- volume
- 1
- pages
- 227 - 231
- publisher
- Pergamon Press Ltd.
- external identifiers
-
- pmid:1845541
- scopus:0026379874
- ISSN
- 1358-6173
- language
- English
- LU publication?
- yes
- id
- ded6c66b-7fd7-4a6c-9569-800aa9ea3c2b (old id 1106005)
- date added to LUP
- 2016-04-01 16:00:27
- date last changed
- 2021-01-03 05:58:12
@article{ded6c66b-7fd7-4a6c-9569-800aa9ea3c2b,
abstract = {{The effect of continuous and intermittent ethanol exposure on the phospholipid composition of Neuroblastoma x Glioma (NG 108-15) cell membranes was investigated. The cells were treated with ethanol for three weeks. Continuous ethanol exposure (150 mM) produced an increase (27%) in the amount of phosphatidylcholine, whereas intermittent ethanol treatment (150 mM) induced a 22% reduction of this lipid. Decreases of phosphatidylethanolamine plasmalogen (8.5%), phosphatidylinositol (16%) and phosphatidylserine (24%) were also seen after intermittent exposure. After binge administration, the concentration of total phospholipids was reduced by 17%, whereas continuous exposure produced a 19% increase. Both intermittent and continuous exposure induced a reduction in the total protein content. No changes in phosphatidic acid, sphingomyelin, phosphatidylcholine plasmalogen or phosphatidylethanolamine (diacyl form) were detected with either treatment. The importance of this study is that ethanol, irrespective of amount, can elicit different effects depending on the pattern of administration.}},
author = {{Alling, Christer and Rodriguez, F D and Gustavsson, L and Simonsson, Per}},
issn = {{1358-6173}},
language = {{eng}},
pages = {{227--231}},
publisher = {{Pergamon Press Ltd.}},
series = {{Alcohol and alcoholism. Supplement}},
title = {{Continuous and intermittent exposure to ethanol: effect on NG 108-15 cell membrane phospholipids}},
volume = {{1}},
year = {{1991}},
}