Topical dsRNA challenges may induce overexpression of airway antiviral cytokines in symptomatic allergic disease. A pilot in vivo study in nasal airways.
(2014) In Respiratory Medicine 108(12). p.1816-1819- Abstract
- Airway challenge with dsRNA is of interest since this agent acts on TLR3 and mimics rhinoviral (RV) infection-induced interferons/cytokines. Contrasting frequent employment of dsRNA in epithelial cell cultures there is no information on effects of dsRNA administered to human airways in vivo. Here we explore effects of nasal dsRNA challenges in subjects with seasonal allergic rhinitis inside and outside Swedish birch pollen season.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4913105
- author
- Brandelius, Angelica LU ; Andersson, Morgan LU and Uller, Lena LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Respiratory Medicine
- volume
- 108
- issue
- 12
- pages
- 1816 - 1819
- publisher
- Elsevier
- external identifiers
-
- pmid:25456711
- wos:000347095900012
- scopus:84927598667
- pmid:25456711
- ISSN
- 1532-3064
- DOI
- 10.1016/j.rmed.2014.10.010
- language
- English
- LU publication?
- yes
- id
- df11e435-2af8-4f21-99fa-b6bb8b66f46e (old id 4913105)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/25456711?dopt=Abstract
- date added to LUP
- 2016-04-01 10:33:09
- date last changed
- 2022-02-17 19:14:32
@article{df11e435-2af8-4f21-99fa-b6bb8b66f46e, abstract = {{Airway challenge with dsRNA is of interest since this agent acts on TLR3 and mimics rhinoviral (RV) infection-induced interferons/cytokines. Contrasting frequent employment of dsRNA in epithelial cell cultures there is no information on effects of dsRNA administered to human airways in vivo. Here we explore effects of nasal dsRNA challenges in subjects with seasonal allergic rhinitis inside and outside Swedish birch pollen season.}}, author = {{Brandelius, Angelica and Andersson, Morgan and Uller, Lena}}, issn = {{1532-3064}}, language = {{eng}}, number = {{12}}, pages = {{1816--1819}}, publisher = {{Elsevier}}, series = {{Respiratory Medicine}}, title = {{Topical dsRNA challenges may induce overexpression of airway antiviral cytokines in symptomatic allergic disease. A pilot in vivo study in nasal airways.}}, url = {{http://dx.doi.org/10.1016/j.rmed.2014.10.010}}, doi = {{10.1016/j.rmed.2014.10.010}}, volume = {{108}}, year = {{2014}}, }