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Hyperbranched Polyesters Based on Indole- and Lignin-Derived Monomeric Aromatic Aldehydes as Effective Nonionic Antimicrobial Coatings with Excellent Biocompatibility

Li, Xiaoya LU ; Wang, Xiao ; Subramaniyan, Sathiyaraj LU ; Liu, Yang LU ; Rao, Jingyi and Zhang, Baozhong LU (2022) In Biomacromolecules 23(1). p.150-162
Abstract

This research aims to investigate nonionic hyperbranched polyesters (HBPs) derived from indole and lignin resources as new nontoxic antimicrobial coatings. Three nonionic HBPs with zero to two methoxy ether substituents on each benzene ring in the polymer backbones were synthesized by melt-polycondensation of three corresponding AB2 monomers. The molecular structures and thermal properties of the obtained HBPs were characterized by gel permeation chromatography, nuclear magnetic resonance spectroscopy, Fourier transform infrared spectroscopy, thermogravimetric analysis, and differential scanning calorimetry analyses. These HBPs were conveniently spin-coated on a silicon substrate, which exhibited significant antibacterial effect against... (More)

This research aims to investigate nonionic hyperbranched polyesters (HBPs) derived from indole and lignin resources as new nontoxic antimicrobial coatings. Three nonionic HBPs with zero to two methoxy ether substituents on each benzene ring in the polymer backbones were synthesized by melt-polycondensation of three corresponding AB2 monomers. The molecular structures and thermal properties of the obtained HBPs were characterized by gel permeation chromatography, nuclear magnetic resonance spectroscopy, Fourier transform infrared spectroscopy, thermogravimetric analysis, and differential scanning calorimetry analyses. These HBPs were conveniently spin-coated on a silicon substrate, which exhibited significant antibacterial effect against Gram-negative (Escherichia coli and Pseudomonas aeruginosa) and Gram-positive bacteria (Staphylococcus aureus and Enterococcus faecalis). The presence of methoxy substituents enhanced the antimicrobial effect, and the resulting polymers showed negligible leakage in water. Finally, the polymers with the methoxy functionality exhibited excellent biocompatibility according to the results of hemolysis and MTT assay, which may facilitate their biomedical applications.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Biomacromolecules
volume
23
issue
1
pages
13 pages
publisher
The American Chemical Society (ACS)
external identifiers
  • scopus:85122036791
  • pmid:34932316
ISSN
1525-7797
DOI
10.1021/acs.biomac.1c01186
language
English
LU publication?
yes
id
df1aa2f3-1c73-48aa-9638-404df4ed241a
date added to LUP
2022-03-23 11:45:56
date last changed
2024-06-22 21:50:05
@article{df1aa2f3-1c73-48aa-9638-404df4ed241a,
  abstract     = {{<p>This research aims to investigate nonionic hyperbranched polyesters (HBPs) derived from indole and lignin resources as new nontoxic antimicrobial coatings. Three nonionic HBPs with zero to two methoxy ether substituents on each benzene ring in the polymer backbones were synthesized by melt-polycondensation of three corresponding AB2 monomers. The molecular structures and thermal properties of the obtained HBPs were characterized by gel permeation chromatography, nuclear magnetic resonance spectroscopy, Fourier transform infrared spectroscopy, thermogravimetric analysis, and differential scanning calorimetry analyses. These HBPs were conveniently spin-coated on a silicon substrate, which exhibited significant antibacterial effect against Gram-negative (Escherichia coli and Pseudomonas aeruginosa) and Gram-positive bacteria (Staphylococcus aureus and Enterococcus faecalis). The presence of methoxy substituents enhanced the antimicrobial effect, and the resulting polymers showed negligible leakage in water. Finally, the polymers with the methoxy functionality exhibited excellent biocompatibility according to the results of hemolysis and MTT assay, which may facilitate their biomedical applications. </p>}},
  author       = {{Li, Xiaoya and Wang, Xiao and Subramaniyan, Sathiyaraj and Liu, Yang and Rao, Jingyi and Zhang, Baozhong}},
  issn         = {{1525-7797}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{1}},
  pages        = {{150--162}},
  publisher    = {{The American Chemical Society (ACS)}},
  series       = {{Biomacromolecules}},
  title        = {{Hyperbranched Polyesters Based on Indole- and Lignin-Derived Monomeric Aromatic Aldehydes as Effective Nonionic Antimicrobial Coatings with Excellent Biocompatibility}},
  url          = {{http://dx.doi.org/10.1021/acs.biomac.1c01186}},
  doi          = {{10.1021/acs.biomac.1c01186}},
  volume       = {{23}},
  year         = {{2022}},
}