Advancements and recent explorations of anti-cancer activity of chrysin : from molecular targets to therapeutic perspective
(2024) In Exploration of Targeted Anti-tumor Therapy 5(3). p.477-494- Abstract
In recent times, there have been notable advancements in comprehending the potential anti-cancer effects of chrysin (CH), a naturally occurring flavonoid compound found abundantly in various plant sources like honey, propolis, and certain fruits and vegetables. This active compound has garnered significant attention due to its promising therapeutic qualities and minimal toxicity. CH’s ability to combat cancer arises from its multifaceted mechanisms of action, including the initiation of apoptosis and the inhibition of proliferation, angiogenesis, metastasis, and cell cycle progression. CH also displays potent antioxidant and antiinflammatory properties, effectively counteracting the harmful molecules that contribute to DNA damage and... (More)
In recent times, there have been notable advancements in comprehending the potential anti-cancer effects of chrysin (CH), a naturally occurring flavonoid compound found abundantly in various plant sources like honey, propolis, and certain fruits and vegetables. This active compound has garnered significant attention due to its promising therapeutic qualities and minimal toxicity. CH’s ability to combat cancer arises from its multifaceted mechanisms of action, including the initiation of apoptosis and the inhibition of proliferation, angiogenesis, metastasis, and cell cycle progression. CH also displays potent antioxidant and antiinflammatory properties, effectively counteracting the harmful molecules that contribute to DNA damage and the development of cancer. Furthermore, CH has exhibited the potential to sensitize cancer cells to traditional chemotherapy and radiotherapy, amplifying the effectiveness of these treatments while reducing their negative impact on healthy cells. Hence, in this current review, the composition, chemistry, mechanisms of action, safety concerns of CH, along with the feasibility of its nanoformulations. To conclude, the recent investigations into CH’s anti-cancer effects present a compelling glimpse into the potential of this natural compound as a complementary therapeutic element in the array of anti-cancer approaches, providing a safer and more comprehensive method of combating this devastating ailment.
(Less)
- author
- Sood, Abhilasha
; Mehrotra, Arpit
; Sharma, Ujjawal
; Aggarwal, Diwakar
; Singh, Tejveer
; Shahwan, Moyad
; Jairoun, Ammar Abdulrahman
; Rani, Isha
; Ramniwas, Seema
; Tuli, Hardeep Singh
; Yadav, Vikas
LU
and Kumar, Manoj
(Less) - organization
- publishing date
- 2024
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- anti-angiogenesis, anti-apoptosis, anti-cancer, anti-metastasis, Chrysin, nanoformulations
- in
- Exploration of Targeted Anti-tumor Therapy
- volume
- 5
- issue
- 3
- pages
- 18 pages
- publisher
- Open Exploration Publishing Inc
- external identifiers
-
- pmid:38966181
- scopus:85196041631
- ISSN
- 2692-3114
- DOI
- 10.37349/etat.2024.00230
- language
- English
- LU publication?
- yes
- id
- df993ac7-157d-4e57-8c09-a3236283f5a1
- date added to LUP
- 2024-09-09 10:54:01
- date last changed
- 2025-07-16 05:13:08
@article{df993ac7-157d-4e57-8c09-a3236283f5a1,
abstract = {{<p>In recent times, there have been notable advancements in comprehending the potential anti-cancer effects of chrysin (CH), a naturally occurring flavonoid compound found abundantly in various plant sources like honey, propolis, and certain fruits and vegetables. This active compound has garnered significant attention due to its promising therapeutic qualities and minimal toxicity. CH’s ability to combat cancer arises from its multifaceted mechanisms of action, including the initiation of apoptosis and the inhibition of proliferation, angiogenesis, metastasis, and cell cycle progression. CH also displays potent antioxidant and antiinflammatory properties, effectively counteracting the harmful molecules that contribute to DNA damage and the development of cancer. Furthermore, CH has exhibited the potential to sensitize cancer cells to traditional chemotherapy and radiotherapy, amplifying the effectiveness of these treatments while reducing their negative impact on healthy cells. Hence, in this current review, the composition, chemistry, mechanisms of action, safety concerns of CH, along with the feasibility of its nanoformulations. To conclude, the recent investigations into CH’s anti-cancer effects present a compelling glimpse into the potential of this natural compound as a complementary therapeutic element in the array of anti-cancer approaches, providing a safer and more comprehensive method of combating this devastating ailment.</p>}},
author = {{Sood, Abhilasha and Mehrotra, Arpit and Sharma, Ujjawal and Aggarwal, Diwakar and Singh, Tejveer and Shahwan, Moyad and Jairoun, Ammar Abdulrahman and Rani, Isha and Ramniwas, Seema and Tuli, Hardeep Singh and Yadav, Vikas and Kumar, Manoj}},
issn = {{2692-3114}},
keywords = {{anti-angiogenesis; anti-apoptosis; anti-cancer; anti-metastasis; Chrysin; nanoformulations}},
language = {{eng}},
number = {{3}},
pages = {{477--494}},
publisher = {{Open Exploration Publishing Inc}},
series = {{Exploration of Targeted Anti-tumor Therapy}},
title = {{Advancements and recent explorations of anti-cancer activity of chrysin : from molecular targets to therapeutic perspective}},
url = {{http://dx.doi.org/10.37349/etat.2024.00230}},
doi = {{10.37349/etat.2024.00230}},
volume = {{5}},
year = {{2024}},
}