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Dosimetry in lymphoscintigraphy of Tc-99m antimony sulfide colloid

Bergqvist, L. LU ; Strand, S. E. LU ; Persson, B. LU orcid ; Hafström, L. and Jönsson, P. E. LU (1982) In Journal of Nuclear Medicine 23(8). p.698-705
Abstract

A quantitative kinetic technique using a scintillation camera has been developed for investigating lymph drainage and the uptake in the lymph nodes of 99mTcSb2S3 colloid injected subcutaneously. Twenty-two patients with primary malignant melanoma were examined. Lymph-node dissection was performed and 185 lymph nodes were individually measured for radioactivity. The kinetics of colloid uptake in individual nodes can be expressed by a simple two-compartment model. The outflow of colloid from the injection site was found to be monoexponential, and the tissue volume containing the injected colloid at the injection site increased asymptotically with time. A model has been developed for calculating absorbed... (More)

A quantitative kinetic technique using a scintillation camera has been developed for investigating lymph drainage and the uptake in the lymph nodes of 99mTcSb2S3 colloid injected subcutaneously. Twenty-two patients with primary malignant melanoma were examined. Lymph-node dissection was performed and 185 lymph nodes were individually measured for radioactivity. The kinetics of colloid uptake in individual nodes can be expressed by a simple two-compartment model. The outflow of colloid from the injection site was found to be monoexponential, and the tissue volume containing the injected colloid at the injection site increased asymptotically with time. A model has been developed for calculating absorbed doses at the injection site and in organs with colloid uptake. The following absorbed doses were estimated (μGy/MBq): whole body 0.7-4.5, gonads 0-22, liver 1.0-3.9, lymph nodes up to 1000 and injection site about 10,000. Possible biological effects in the skin and effective dose equivalents have been estimated when using other lymphoscintiscanning agents.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Nuclear Medicine
volume
23
issue
8
pages
698 - 705
publisher
Society of Nuclear Medicine
external identifiers
  • pmid:7108614
  • scopus:0019969697
ISSN
0161-5505
language
English
LU publication?
yes
id
dfda9a60-e01f-4afa-a8c7-89d447c70df4
alternative location
http://jnm.snmjournals.org/content/23/8/698.long
date added to LUP
2020-08-15 17:18:17
date last changed
2024-01-02 17:02:19
@article{dfda9a60-e01f-4afa-a8c7-89d447c70df4,
  abstract     = {{<p>A quantitative kinetic technique using a scintillation camera has been developed for investigating lymph drainage and the uptake in the lymph nodes of <sup>99m</sup>TcSb<sub>2</sub>S<sub>3</sub> colloid injected subcutaneously. Twenty-two patients with primary malignant melanoma were examined. Lymph-node dissection was performed and 185 lymph nodes were individually measured for radioactivity. The kinetics of colloid uptake in individual nodes can be expressed by a simple two-compartment model. The outflow of colloid from the injection site was found to be monoexponential, and the tissue volume containing the injected colloid at the injection site increased asymptotically with time. A model has been developed for calculating absorbed doses at the injection site and in organs with colloid uptake. The following absorbed doses were estimated (μGy/MBq): whole body 0.7-4.5, gonads 0-22, liver 1.0-3.9, lymph nodes up to 1000 and injection site about 10,000. Possible biological effects in the skin and effective dose equivalents have been estimated when using other lymphoscintiscanning agents.</p>}},
  author       = {{Bergqvist, L. and Strand, S. E. and Persson, B. and Hafström, L. and Jönsson, P. E.}},
  issn         = {{0161-5505}},
  language     = {{eng}},
  month        = {{08}},
  number       = {{8}},
  pages        = {{698--705}},
  publisher    = {{Society of Nuclear Medicine}},
  series       = {{Journal of Nuclear Medicine}},
  title        = {{Dosimetry in lymphoscintigraphy of Tc-99m antimony sulfide colloid}},
  url          = {{http://jnm.snmjournals.org/content/23/8/698.long}},
  volume       = {{23}},
  year         = {{1982}},
}