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Distribution of CGRP and CGRP receptor components in the rat brain

Warfvinge, Karin LU and Edvinsson, Lars LU (2019) In Cephalalgia 39(3). p.342-353
Abstract

Background: Calcitonin gene-related peptide and its receptor, consisting of receptor activity-modifying protein 1 and calcitonin receptor-like receptor, are of considerable interest because of the role they play in migraine and recently developed migraine therapies. Methods: To better understand the function of this neuropeptide, we used immunohistochemistry to determine a detailed distribution of calcitonin gene-related peptide, receptor activity-modifying protein 1 and calcitonin receptor-like receptor in the rat brain in a region of 0.5–1.5 mm lateral to the midline. We found calcitonin gene-related peptide immunoreactivity in most of the neurons of the cerebral cortex, hippocampus, cerebellum, thalamic nuclei, hypothalamic nuclei... (More)

Background: Calcitonin gene-related peptide and its receptor, consisting of receptor activity-modifying protein 1 and calcitonin receptor-like receptor, are of considerable interest because of the role they play in migraine and recently developed migraine therapies. Methods: To better understand the function of this neuropeptide, we used immunohistochemistry to determine a detailed distribution of calcitonin gene-related peptide, receptor activity-modifying protein 1 and calcitonin receptor-like receptor in the rat brain in a region of 0.5–1.5 mm lateral to the midline. We found calcitonin gene-related peptide immunoreactivity in most of the neurons of the cerebral cortex, hippocampus, cerebellum, thalamic nuclei, hypothalamic nuclei and brainstem nuclei. In contrast, receptor activity-modifying protein 1 and calcitonin receptor-like receptor immunoreactivity were found almost exclusively in the neuronal processes in the investigated regions. Conclusion: Overall, the degree of expression of calcitonin gene-related peptide and calcitonin gene-related peptide receptor components in the central nervous system is astonishingly complex and suggestive of many different brain functions, including a possible role in migraine. However, currently, the presence of calcitonin gene-related peptide and the nature of its receptors throughout the brain is an enigma yet to be solved.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
CGRP, immunohistochemistry, Migraine, RAMP1/CLR, rat brain
in
Cephalalgia
volume
39
issue
3
pages
12 pages
publisher
Wiley-Blackwell
external identifiers
  • scopus:85062397702
  • pmid:28856910
ISSN
0333-1024
DOI
10.1177/0333102417728873
language
English
LU publication?
yes
id
e00165f2-7a7f-4c27-a3c1-24a54c185d24
date added to LUP
2019-03-13 10:07:54
date last changed
2020-08-05 05:12:22
@article{e00165f2-7a7f-4c27-a3c1-24a54c185d24,
  abstract     = {<p>Background: Calcitonin gene-related peptide and its receptor, consisting of receptor activity-modifying protein 1 and calcitonin receptor-like receptor, are of considerable interest because of the role they play in migraine and recently developed migraine therapies. Methods: To better understand the function of this neuropeptide, we used immunohistochemistry to determine a detailed distribution of calcitonin gene-related peptide, receptor activity-modifying protein 1 and calcitonin receptor-like receptor in the rat brain in a region of 0.5–1.5 mm lateral to the midline. We found calcitonin gene-related peptide immunoreactivity in most of the neurons of the cerebral cortex, hippocampus, cerebellum, thalamic nuclei, hypothalamic nuclei and brainstem nuclei. In contrast, receptor activity-modifying protein 1 and calcitonin receptor-like receptor immunoreactivity were found almost exclusively in the neuronal processes in the investigated regions. Conclusion: Overall, the degree of expression of calcitonin gene-related peptide and calcitonin gene-related peptide receptor components in the central nervous system is astonishingly complex and suggestive of many different brain functions, including a possible role in migraine. However, currently, the presence of calcitonin gene-related peptide and the nature of its receptors throughout the brain is an enigma yet to be solved.</p>},
  author       = {Warfvinge, Karin and Edvinsson, Lars},
  issn         = {0333-1024},
  language     = {eng},
  number       = {3},
  pages        = {342--353},
  publisher    = {Wiley-Blackwell},
  series       = {Cephalalgia},
  title        = {Distribution of CGRP and CGRP receptor components in the rat brain},
  url          = {http://dx.doi.org/10.1177/0333102417728873},
  doi          = {10.1177/0333102417728873},
  volume       = {39},
  year         = {2019},
}