Distribution of CGRP and CGRP receptor components in the rat brain
(2019) In Cephalalgia 39(3). p.342-353- Abstract
Background: Calcitonin gene-related peptide and its receptor, consisting of receptor activity-modifying protein 1 and calcitonin receptor-like receptor, are of considerable interest because of the role they play in migraine and recently developed migraine therapies. Methods: To better understand the function of this neuropeptide, we used immunohistochemistry to determine a detailed distribution of calcitonin gene-related peptide, receptor activity-modifying protein 1 and calcitonin receptor-like receptor in the rat brain in a region of 0.5–1.5 mm lateral to the midline. We found calcitonin gene-related peptide immunoreactivity in most of the neurons of the cerebral cortex, hippocampus, cerebellum, thalamic nuclei, hypothalamic nuclei... (More)
Background: Calcitonin gene-related peptide and its receptor, consisting of receptor activity-modifying protein 1 and calcitonin receptor-like receptor, are of considerable interest because of the role they play in migraine and recently developed migraine therapies. Methods: To better understand the function of this neuropeptide, we used immunohistochemistry to determine a detailed distribution of calcitonin gene-related peptide, receptor activity-modifying protein 1 and calcitonin receptor-like receptor in the rat brain in a region of 0.5–1.5 mm lateral to the midline. We found calcitonin gene-related peptide immunoreactivity in most of the neurons of the cerebral cortex, hippocampus, cerebellum, thalamic nuclei, hypothalamic nuclei and brainstem nuclei. In contrast, receptor activity-modifying protein 1 and calcitonin receptor-like receptor immunoreactivity were found almost exclusively in the neuronal processes in the investigated regions. Conclusion: Overall, the degree of expression of calcitonin gene-related peptide and calcitonin gene-related peptide receptor components in the central nervous system is astonishingly complex and suggestive of many different brain functions, including a possible role in migraine. However, currently, the presence of calcitonin gene-related peptide and the nature of its receptors throughout the brain is an enigma yet to be solved.
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- author
- Warfvinge, Karin LU and Edvinsson, Lars LU
- organization
- publishing date
- 2019
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- CGRP, immunohistochemistry, Migraine, RAMP1/CLR, rat brain
- in
- Cephalalgia
- volume
- 39
- issue
- 3
- pages
- 12 pages
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:28856910
- scopus:85062397702
- ISSN
- 0333-1024
- DOI
- 10.1177/0333102417728873
- language
- English
- LU publication?
- yes
- id
- e00165f2-7a7f-4c27-a3c1-24a54c185d24
- date added to LUP
- 2019-03-13 10:07:54
- date last changed
- 2024-09-17 15:40:41
@article{e00165f2-7a7f-4c27-a3c1-24a54c185d24, abstract = {{<p>Background: Calcitonin gene-related peptide and its receptor, consisting of receptor activity-modifying protein 1 and calcitonin receptor-like receptor, are of considerable interest because of the role they play in migraine and recently developed migraine therapies. Methods: To better understand the function of this neuropeptide, we used immunohistochemistry to determine a detailed distribution of calcitonin gene-related peptide, receptor activity-modifying protein 1 and calcitonin receptor-like receptor in the rat brain in a region of 0.5–1.5 mm lateral to the midline. We found calcitonin gene-related peptide immunoreactivity in most of the neurons of the cerebral cortex, hippocampus, cerebellum, thalamic nuclei, hypothalamic nuclei and brainstem nuclei. In contrast, receptor activity-modifying protein 1 and calcitonin receptor-like receptor immunoreactivity were found almost exclusively in the neuronal processes in the investigated regions. Conclusion: Overall, the degree of expression of calcitonin gene-related peptide and calcitonin gene-related peptide receptor components in the central nervous system is astonishingly complex and suggestive of many different brain functions, including a possible role in migraine. However, currently, the presence of calcitonin gene-related peptide and the nature of its receptors throughout the brain is an enigma yet to be solved.</p>}}, author = {{Warfvinge, Karin and Edvinsson, Lars}}, issn = {{0333-1024}}, keywords = {{CGRP; immunohistochemistry; Migraine; RAMP1/CLR; rat brain}}, language = {{eng}}, number = {{3}}, pages = {{342--353}}, publisher = {{Wiley-Blackwell}}, series = {{Cephalalgia}}, title = {{Distribution of CGRP and CGRP receptor components in the rat brain}}, url = {{http://dx.doi.org/10.1177/0333102417728873}}, doi = {{10.1177/0333102417728873}}, volume = {{39}}, year = {{2019}}, }