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Systemic and intraocular uptake of spantide, a tachykinin antagonist, following topical application to the rabbit eye.

Beding-Barnekow, B. ; Leander, S. ; Ohlin, M. LU orcid ; Ninn-Pedersen, K. ; Alkner, U. and Håkanson, R. LU (1990) In Experimental Eye Research 50(1). p.21-26
Abstract
Previous observations have indicated that topical application to the rabbit eye of tachykinin antagonists, including spantide, effectively prevents the miosis and the disruption of the blood-aqueous barrier consequent to ocular injury. The present study shows that spantide is taken up into the rabbit eye following topical application. This was established by determination of spantide in the aqueous humor by radioimmunoassay. The concentrations reached in the aqueous humor were those that could be expected to block tachykinin receptors. The elimination of spantide from the aqueous humor was found to be slow. From HPLC analysis it seemed that spantide in the aqueous humor is degraded to smaller products, predominantly spantide 5–11. Some of... (More)
Previous observations have indicated that topical application to the rabbit eye of tachykinin antagonists, including spantide, effectively prevents the miosis and the disruption of the blood-aqueous barrier consequent to ocular injury. The present study shows that spantide is taken up into the rabbit eye following topical application. This was established by determination of spantide in the aqueous humor by radioimmunoassay. The concentrations reached in the aqueous humor were those that could be expected to block tachykinin receptors. The elimination of spantide from the aqueous humor was found to be slow. From HPLC analysis it seemed that spantide in the aqueous humor is degraded to smaller products, predominantly spantide 5–11. Some of the topically applied peptide appeared in the general circulation. Here the rate of elimination was rapid by comparison. Very small amounts of spantide appeared in the cerebrospinal fluid after intravenous injection. (Less)
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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Experimental Eye Research
volume
50
issue
1
pages
21 - 26
publisher
Elsevier
external identifiers
  • scopus:0025092012
ISSN
0014-4835
DOI
10.1016/0014-4835(90)90006-G
language
English
LU publication?
yes
id
e0078681-ef21-4957-9bc0-e285d386122a
date added to LUP
2022-12-05 08:21:07
date last changed
2023-04-10 04:02:38
@article{e0078681-ef21-4957-9bc0-e285d386122a,
  abstract     = {{Previous observations have indicated that topical application to the rabbit eye of tachykinin antagonists, including spantide, effectively prevents the miosis and the disruption of the blood-aqueous barrier consequent to ocular injury. The present study shows that spantide is taken up into the rabbit eye following topical application. This was established by determination of spantide in the aqueous humor by radioimmunoassay. The concentrations reached in the aqueous humor were those that could be expected to block tachykinin receptors. The elimination of spantide from the aqueous humor was found to be slow. From HPLC analysis it seemed that spantide in the aqueous humor is degraded to smaller products, predominantly spantide 5–11. Some of the topically applied peptide appeared in the general circulation. Here the rate of elimination was rapid by comparison. Very small amounts of spantide appeared in the cerebrospinal fluid after intravenous injection.}},
  author       = {{Beding-Barnekow, B. and Leander, S. and Ohlin, M. and Ninn-Pedersen, K. and Alkner, U. and Håkanson, R.}},
  issn         = {{0014-4835}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{21--26}},
  publisher    = {{Elsevier}},
  series       = {{Experimental Eye Research}},
  title        = {{Systemic and intraocular uptake of spantide, a tachykinin antagonist, following topical application to the rabbit eye.}},
  url          = {{http://dx.doi.org/10.1016/0014-4835(90)90006-G}},
  doi          = {{10.1016/0014-4835(90)90006-G}},
  volume       = {{50}},
  year         = {{1990}},
}