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Water Supplementation Reduces Copeptin and Plasma Glucose in Adults With High Copeptin : The H2O Metabolism Pilot Study

Enhörning, Sofia LU ; Brunkwall, Louise LU ; Tasevska, Irina LU ; Ericson, Ulrika LU ; Persson Tholin, Jenny; Persson, Margaretha LU ; Lemetais, Guillaume; Vanhaecke, Tiphaine; Dolci, Alberto and Perrier, Erica T, et al. (2019) In The Journal of clinical endocrinology and metabolism 104(6). p.1917-1925
Abstract

OBJECTIVE: Because elevated copeptin, a marker of vasopressin, is linked to low water intake and high diabetes risk, we tested the effect of water supplementation on copeptin and fasting glucose.

DESIGN, SETTING, AND PARTICIPANTS: Thirty-one healthy adults with high copeptin (>10.7 pmol · L-1 in men and >6.1 pmol·L-1 in women) identified in a population-based survey from 2013 to 2015 and with a current 24-hour urine osmolality of >600 mOsm · kg-1 were included.

INTERVENTION: Addition of 1.5 L water daily on top of habitual fluid intake for 6 weeks.

MAIN OUTCOME MEASURE: Pre- and postintervention fasting plasma copeptin concentrations.

RESULTS: Reported mean water intake increased from 0.43 to 1.35 L ·... (More)

OBJECTIVE: Because elevated copeptin, a marker of vasopressin, is linked to low water intake and high diabetes risk, we tested the effect of water supplementation on copeptin and fasting glucose.

DESIGN, SETTING, AND PARTICIPANTS: Thirty-one healthy adults with high copeptin (>10.7 pmol · L-1 in men and >6.1 pmol·L-1 in women) identified in a population-based survey from 2013 to 2015 and with a current 24-hour urine osmolality of >600 mOsm · kg-1 were included.

INTERVENTION: Addition of 1.5 L water daily on top of habitual fluid intake for 6 weeks.

MAIN OUTCOME MEASURE: Pre- and postintervention fasting plasma copeptin concentrations.

RESULTS: Reported mean water intake increased from 0.43 to 1.35 L · d-1 (P < 0.001), with no other observed changes in diet. Median (interquartile range) urine osmolality was reduced from 879 (705, 996) to 384 (319, 502) mOsm · kg-1 (P < 0.001); urine volume increased from 1.06 (0.90, 1.20) to 2.27 (1.52, 2.67) L · d-1 (P < 0.001); and baseline copeptin decreased from 12.9 (7.4, 21.9) pmol · L-1 to 7.8 (4.6;11.3) pmol · L-1 (P < 0.001). Water supplementation reduced fasting plasma glucose from a mean (SD) of 5.94 (0.44) to 5.74 (0.51) (P = 0.04). The water-associated reduction of both fasting copeptin and glucose concentration in plasma was most pronounced in participants in the top tertile of baseline copeptin.

CONCLUSIONS: Water supplementation in persons with habitually low water consumption and high copeptin levels is effective in lowering copeptin. It appears a safe and promising intervention with the potential of lowering fasting plasma glucose and thus reducing diabetes risk. Further investigations are warranted to support these findings.

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The Journal of clinical endocrinology and metabolism
volume
104
issue
6
pages
9 pages
publisher
The Endocrine Society
external identifiers
  • scopus:85063756741
ISSN
1945-7197
DOI
10.1210/jc.2018-02195
language
English
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yes
id
e00c4d89-ef12-4d42-9fc1-b94975575fa4
date added to LUP
2019-06-24 09:36:08
date last changed
2019-10-15 07:08:30
@article{e00c4d89-ef12-4d42-9fc1-b94975575fa4,
  abstract     = {<p>OBJECTIVE: Because elevated copeptin, a marker of vasopressin, is linked to low water intake and high diabetes risk, we tested the effect of water supplementation on copeptin and fasting glucose.</p><p>DESIGN, SETTING, AND PARTICIPANTS: Thirty-one healthy adults with high copeptin (&gt;10.7 pmol · L-1 in men and &gt;6.1 pmol·L-1 in women) identified in a population-based survey from 2013 to 2015 and with a current 24-hour urine osmolality of &gt;600 mOsm · kg-1 were included.</p><p>INTERVENTION: Addition of 1.5 L water daily on top of habitual fluid intake for 6 weeks.</p><p>MAIN OUTCOME MEASURE: Pre- and postintervention fasting plasma copeptin concentrations.</p><p>RESULTS: Reported mean water intake increased from 0.43 to 1.35 L · d-1 (P &lt; 0.001), with no other observed changes in diet. Median (interquartile range) urine osmolality was reduced from 879 (705, 996) to 384 (319, 502) mOsm · kg-1 (P &lt; 0.001); urine volume increased from 1.06 (0.90, 1.20) to 2.27 (1.52, 2.67) L · d-1 (P &lt; 0.001); and baseline copeptin decreased from 12.9 (7.4, 21.9) pmol · L-1 to 7.8 (4.6;11.3) pmol · L-1 (P &lt; 0.001). Water supplementation reduced fasting plasma glucose from a mean (SD) of 5.94 (0.44) to 5.74 (0.51) (P = 0.04). The water-associated reduction of both fasting copeptin and glucose concentration in plasma was most pronounced in participants in the top tertile of baseline copeptin.</p><p>CONCLUSIONS: Water supplementation in persons with habitually low water consumption and high copeptin levels is effective in lowering copeptin. It appears a safe and promising intervention with the potential of lowering fasting plasma glucose and thus reducing diabetes risk. Further investigations are warranted to support these findings.</p>},
  author       = {Enhörning, Sofia and Brunkwall, Louise and Tasevska, Irina and Ericson, Ulrika and Persson Tholin, Jenny and Persson, Margaretha and Lemetais, Guillaume and Vanhaecke, Tiphaine and Dolci, Alberto and Perrier, Erica T and Melander, Olle},
  issn         = {1945-7197},
  language     = {eng},
  month        = {06},
  number       = {6},
  pages        = {1917--1925},
  publisher    = {The Endocrine Society},
  series       = {The Journal of clinical endocrinology and metabolism},
  title        = {Water Supplementation Reduces Copeptin and Plasma Glucose in Adults With High Copeptin : The H2O Metabolism Pilot Study},
  url          = {http://dx.doi.org/10.1210/jc.2018-02195},
  volume       = {104},
  year         = {2019},
}