Oral microbiota in patients with atherosclerosis
Fåk, Frida LU
; Tremaroli, Valentina
; Bergström, Göran
and Bäckhed, Fredrik
(2015)
In Atherosclerosis
243(2).
p.573-578
- Abstract
Background and aims: Recent evidence suggests that the microbiota may be considered as an environmental factor that contributes to the development of atherosclerosis. Periodontal disease has been associated with cardio- and cerebrovascular events, and inflammation in the periodontium is suggested to increase the systemic inflammatory level of the host, which may in turn influence plaque composition and rupture. We previously showed that bacteria from the oral cavity and the gut could be found in atherosclerotic plaques. Methods: To elucidate whether the oral microbiota composition differed between patients with asymptomatic and symptomatic atherosclerosis we performed pyrosequencing of the oral microbiota of 92 individuals including... (More)
Background and aims: Recent evidence suggests that the microbiota may be considered as an environmental factor that contributes to the development of atherosclerosis. Periodontal disease has been associated with cardio- and cerebrovascular events, and inflammation in the periodontium is suggested to increase the systemic inflammatory level of the host, which may in turn influence plaque composition and rupture. We previously showed that bacteria from the oral cavity and the gut could be found in atherosclerotic plaques. Methods: To elucidate whether the oral microbiota composition differed between patients with asymptomatic and symptomatic atherosclerosis we performed pyrosequencing of the oral microbiota of 92 individuals including patients with asymptomatic and symptomatic atherosclerosis and control individuals without carotid plaques or previous stroke or myocardial infarction. Results: The overall microbial structure was similar in controls and atherosclerosis patients, but patients with symptomatic atherosclerosis had higher relative abundance of Anaeroglobus (mean 0.040% (SD 0.049)) than the control group (0.010% (SD 0.028)) (P = 0.03). Using linear regression analysis, we found that Parvimonas associated positively with uCRP and Capnocytophaga, Catonella and Lactobacillus associated with blood lipid markers. In conclusion, abundance of Anaeroglobus in the oral cavity could be associated with symptomatic atherosclerosis.
(Less)
- author
- Fåk, Frida
LU
; Tremaroli, Valentina
; Bergström, Göran
and Bäckhed, Fredrik
- publishing date
- 2015-12-01
- type
- Contribution to journal
- publication status
- published
- keywords
- Atherosclerosis, Oral microbiota, Pyrosequencing
- in
- Atherosclerosis
- volume
- 243
- issue
- 2
- pages
- 6 pages
- publisher
- Elsevier
- external identifiers
-
- pmid:26536303
- scopus:84946433552
- ISSN
- 0021-9150
- DOI
- 10.1016/j.atherosclerosis.2015.10.097
- language
- English
- LU publication?
- no
- additional info
- Publisher Copyright: © 2015 Elsevier Ireland Ltd.
- id
- e0183ae0-a9a7-4521-bf81-0483c605c0cd
- date added to LUP
- 2024-12-05 12:47:59
- date last changed
- 2025-06-06 03:44:05
@article{e0183ae0-a9a7-4521-bf81-0483c605c0cd,
abstract = {{<p>Background and aims: Recent evidence suggests that the microbiota may be considered as an environmental factor that contributes to the development of atherosclerosis. Periodontal disease has been associated with cardio- and cerebrovascular events, and inflammation in the periodontium is suggested to increase the systemic inflammatory level of the host, which may in turn influence plaque composition and rupture. We previously showed that bacteria from the oral cavity and the gut could be found in atherosclerotic plaques. Methods: To elucidate whether the oral microbiota composition differed between patients with asymptomatic and symptomatic atherosclerosis we performed pyrosequencing of the oral microbiota of 92 individuals including patients with asymptomatic and symptomatic atherosclerosis and control individuals without carotid plaques or previous stroke or myocardial infarction. Results: The overall microbial structure was similar in controls and atherosclerosis patients, but patients with symptomatic atherosclerosis had higher relative abundance of Anaeroglobus (mean 0.040% (SD 0.049)) than the control group (0.010% (SD 0.028)) (P = 0.03). Using linear regression analysis, we found that Parvimonas associated positively with uCRP and Capnocytophaga, Catonella and Lactobacillus associated with blood lipid markers. In conclusion, abundance of Anaeroglobus in the oral cavity could be associated with symptomatic atherosclerosis.</p>}},
author = {{Fåk, Frida and Tremaroli, Valentina and Bergström, Göran and Bäckhed, Fredrik}},
issn = {{0021-9150}},
keywords = {{Atherosclerosis; Oral microbiota; Pyrosequencing}},
language = {{eng}},
month = {{12}},
number = {{2}},
pages = {{573--578}},
publisher = {{Elsevier}},
series = {{Atherosclerosis}},
title = {{Oral microbiota in patients with atherosclerosis}},
url = {{http://dx.doi.org/10.1016/j.atherosclerosis.2015.10.097}},
doi = {{10.1016/j.atherosclerosis.2015.10.097}},
volume = {{243}},
year = {{2015}},
}