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RENEB/EURADOS field exercise 2019 : robust dose estimation under outdoor conditions based on the dicentric chromosome assay

Endesfelder, David ; Oestreicher, Ursula ; Kulka, Ulrike ; Ainsbury, Elizabeth A. ; Moquet, Jayne ; Barnard, Stephen ; Gregoire, Eric ; Martinez, Juan S. ; Trompier, François and Ristic, Yoann , et al. (2021) In International Journal of Radiation Biology 97(9). p.1181-1198
Abstract

Purpose: Biological and/or physical assays for retrospective dosimetry are valuable tools to recover the exposure situation and to aid medical decision making. To further validate and improve such biological and physical assays, in 2019, EURADOS Working Group 10 and RENEB performed a field exercise in Lund, Sweden, to simulate various real-life exposure scenarios. Materials and methods: For the dicentric chromosome assay (DCA), blood tubes were located at anthropomorphic phantoms positioned in different geometries and were irradiated with a 1.36 TBq 192Ir-source. For each exposure condition, dose estimates were provided by at least one laboratory and for four conditions by 17 participating RENEB laboratories. Three... (More)

Purpose: Biological and/or physical assays for retrospective dosimetry are valuable tools to recover the exposure situation and to aid medical decision making. To further validate and improve such biological and physical assays, in 2019, EURADOS Working Group 10 and RENEB performed a field exercise in Lund, Sweden, to simulate various real-life exposure scenarios. Materials and methods: For the dicentric chromosome assay (DCA), blood tubes were located at anthropomorphic phantoms positioned in different geometries and were irradiated with a 1.36 TBq 192Ir-source. For each exposure condition, dose estimates were provided by at least one laboratory and for four conditions by 17 participating RENEB laboratories. Three radio-photoluminescence glass dosimeters were placed at each tube to assess reference doses. Results: The DCA results were homogeneous between participants and matched well with the reference doses (≥95% of estimates within ±0.5 Gy of the reference). For samples close to the source systematic underestimation could be corrected by accounting for exposure time. Heterogeneity within and between tubes was detected for reference doses as well as for DCA doses estimates. Conclusions: The participants were able to successfully estimate the doses and to provide important information on the exposure scenarios under conditions closely resembling a real-life situation.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
biological dosimetry, Dicentric chromosome, EURADOS, inter-laboratory comparison, RENEB
in
International Journal of Radiation Biology
volume
97
issue
9
pages
18 pages
publisher
Taylor & Francis
external identifiers
  • scopus:85109840839
  • pmid:34138666
ISSN
0955-3002
DOI
10.1080/09553002.2021.1941380
language
English
LU publication?
yes
id
e04bb687-9f80-4933-86e2-2ec8c451b973
date added to LUP
2022-01-27 11:25:42
date last changed
2024-06-30 01:35:43
@article{e04bb687-9f80-4933-86e2-2ec8c451b973,
  abstract     = {{<p>Purpose: Biological and/or physical assays for retrospective dosimetry are valuable tools to recover the exposure situation and to aid medical decision making. To further validate and improve such biological and physical assays, in 2019, EURADOS Working Group 10 and RENEB performed a field exercise in Lund, Sweden, to simulate various real-life exposure scenarios. Materials and methods: For the dicentric chromosome assay (DCA), blood tubes were located at anthropomorphic phantoms positioned in different geometries and were irradiated with a 1.36 TBq <sup>192</sup>Ir-source. For each exposure condition, dose estimates were provided by at least one laboratory and for four conditions by 17 participating RENEB laboratories. Three radio-photoluminescence glass dosimeters were placed at each tube to assess reference doses. Results: The DCA results were homogeneous between participants and matched well with the reference doses (≥95% of estimates within ±0.5 Gy of the reference). For samples close to the source systematic underestimation could be corrected by accounting for exposure time. Heterogeneity within and between tubes was detected for reference doses as well as for DCA doses estimates. Conclusions: The participants were able to successfully estimate the doses and to provide important information on the exposure scenarios under conditions closely resembling a real-life situation.</p>}},
  author       = {{Endesfelder, David and Oestreicher, Ursula and Kulka, Ulrike and Ainsbury, Elizabeth A. and Moquet, Jayne and Barnard, Stephen and Gregoire, Eric and Martinez, Juan S. and Trompier, François and Ristic, Yoann and Woda, Clemens and Waldner, Lovisa and Beinke, Christina and Vral, Anne and Barquinero, Joan Francesc and Hernandez, Alfredo and Sommer, Sylwester and Lumniczky, Katalin and Hargitai, Rita and Montoro, Alegría and Milic, Mirta and Monteiro Gil, Octávia and Valente, Marco and Bobyk, Laure and Sevriukova, Olga and Sabatier, Laure and Prieto, María Jesús and Moreno Domene, Mercedes and Testa, Antonella and Patrono, Clarice and Terzoudi, Georgia and Triantopoulou, Sotiria and Histova, Rositsa and Wojcik, Andrzej}},
  issn         = {{0955-3002}},
  keywords     = {{biological dosimetry; Dicentric chromosome; EURADOS; inter-laboratory comparison; RENEB}},
  language     = {{eng}},
  number       = {{9}},
  pages        = {{1181--1198}},
  publisher    = {{Taylor & Francis}},
  series       = {{International Journal of Radiation Biology}},
  title        = {{RENEB/EURADOS field exercise 2019 : robust dose estimation under outdoor conditions based on the dicentric chromosome assay}},
  url          = {{http://dx.doi.org/10.1080/09553002.2021.1941380}},
  doi          = {{10.1080/09553002.2021.1941380}},
  volume       = {{97}},
  year         = {{2021}},
}