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Immunsvar och inflammation vid Crohns sjukdom. Snart möjligt driva diagnostiken längre och utveckla mer specifika läkemedel

Lindgren, S LU and Egesten, A LU (1999) In Lakartidningen 96(1-2). p.5-52
Abstract

The chronic inflammation in Crohn's disease may be caused by aggressive response to bacterial antigens normal to the gut. Genetic and environmental factors modify the inflammatory response evoked by damage to the mucosal gut barrier. Genetic factors may also determine the subsequent course of chronic inflammation. Further elucidation of the pathogenesis might improve our understanding of the heterogenous nature of Crohn's disease, thus enabling the disease to be subtyped and individualised therapy directed primarily at down-regulation of helper T-cell-1 response to be developed.

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author
alternative title
Immune response and inflammation in Crohn disease. More detailed diagnostics and more specific drugs are soon to be available
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Crohn Disease, Humans, T-Lymphocytes, Helper-Inducer, English Abstract, Journal Article, Review
in
Lakartidningen
volume
96
issue
1-2
pages
4 pages
publisher
Sveriges Läkarförbund
ISSN
0023-7205
language
Swedish
LU publication?
no
id
e057fac2-e27a-421e-be4b-5ffcfb026680
date added to LUP
2017-02-03 16:07:12
date last changed
2017-08-05 04:00:09
@article{e057fac2-e27a-421e-be4b-5ffcfb026680,
  abstract     = {<p>The chronic inflammation in Crohn's disease may be caused by aggressive response to bacterial antigens normal to the gut. Genetic and environmental factors modify the inflammatory response evoked by damage to the mucosal gut barrier. Genetic factors may also determine the subsequent course of chronic inflammation. Further elucidation of the pathogenesis might improve our understanding of the heterogenous nature of Crohn's disease, thus enabling the disease to be subtyped and individualised therapy directed primarily at down-regulation of helper T-cell-1 response to be developed.</p>},
  author       = {Lindgren, S and Egesten, A},
  issn         = {0023-7205},
  keyword      = {Crohn Disease,Humans,T-Lymphocytes, Helper-Inducer,English Abstract,Journal Article,Review},
  language     = {swe},
  month        = {01},
  number       = {1-2},
  pages        = {5--52},
  publisher    = {Sveriges Läkarförbund},
  series       = {Lakartidningen},
  title        = {Immunsvar och inflammation vid Crohns sjukdom. Snart möjligt driva diagnostiken längre och utveckla mer specifika läkemedel},
  volume       = {96},
  year         = {1999},
}