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Decreasing cumulative incidence of end-stage renal disease in young patients with type 1 diabetes in Sweden : A 38-year prospective nationwide study

, ; Toppe, Cecilia; Möllsten, Anna; Waernbaum, Ingeborg; Schön, Staffan; Gudbjörnsdottir, Soffia; Landin-Olsson, Mona LU and Dahlquist, Gisela (2019) In Diabetes Care 42(1). p.27-31
Abstract

OBJECTIVE Diabetic nephropathy is a serious complication of type 1 diabetes. Recent studies indicate that end-stage renal disease (ESRD) incidence has decreased or that the onset of ESRD has been postponed; therefore, we wanted to analyze the incidence and time trends of ESRD in Sweden. RESEARCH DESIGN AND METHODS In this study, patients with duration of type 1 diabetes >14 years and age at onset of diabetes 0–34 years were included. Three national diabetes registers were used: the Swedish Childhood Diabetes Register, the Diabetes Incidence Study in Sweden, and the National Diabetes Register. The Swedish Renal Registry, a national register on renal replacement therapy, was used to identify patients who developed ESRD. RESULTS We... (More)

OBJECTIVE Diabetic nephropathy is a serious complication of type 1 diabetes. Recent studies indicate that end-stage renal disease (ESRD) incidence has decreased or that the onset of ESRD has been postponed; therefore, we wanted to analyze the incidence and time trends of ESRD in Sweden. RESEARCH DESIGN AND METHODS In this study, patients with duration of type 1 diabetes >14 years and age at onset of diabetes 0–34 years were included. Three national diabetes registers were used: the Swedish Childhood Diabetes Register, the Diabetes Incidence Study in Sweden, and the National Diabetes Register. The Swedish Renal Registry, a national register on renal replacement therapy, was used to identify patients who developed ESRD. RESULTS We found that the cumulative incidence of ESRD in Sweden was low after up to 38 years of diabetes duration (5.6%). The incidence of ESRD was lower in patients with type 1 diabetes onset in 1991–2001 compared with onset in 1977–1984 and 1985–1990, independent of diabetes duration. CONCLUSIONS The risk of developing ESRD in Sweden in this population is still low and also seems to decrease with time.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabetes Care
volume
42
issue
1
pages
5 pages
publisher
American Diabetes Association
external identifiers
  • scopus:85059071263
ISSN
0149-5992
DOI
10.2337/dc18-1276
language
English
LU publication?
yes
id
e05a3bda-8965-4149-a3ce-59606ee41316
date added to LUP
2019-01-03 08:06:03
date last changed
2019-04-23 04:44:07
@article{e05a3bda-8965-4149-a3ce-59606ee41316,
  abstract     = {<p>OBJECTIVE Diabetic nephropathy is a serious complication of type 1 diabetes. Recent studies indicate that end-stage renal disease (ESRD) incidence has decreased or that the onset of ESRD has been postponed; therefore, we wanted to analyze the incidence and time trends of ESRD in Sweden. RESEARCH DESIGN AND METHODS In this study, patients with duration of type 1 diabetes &gt;14 years and age at onset of diabetes 0–34 years were included. Three national diabetes registers were used: the Swedish Childhood Diabetes Register, the Diabetes Incidence Study in Sweden, and the National Diabetes Register. The Swedish Renal Registry, a national register on renal replacement therapy, was used to identify patients who developed ESRD. RESULTS We found that the cumulative incidence of ESRD in Sweden was low after up to 38 years of diabetes duration (5.6%). The incidence of ESRD was lower in patients with type 1 diabetes onset in 1991–2001 compared with onset in 1977–1984 and 1985–1990, independent of diabetes duration. CONCLUSIONS The risk of developing ESRD in Sweden in this population is still low and also seems to decrease with time.</p>},
  author       = {,  and Toppe, Cecilia and Möllsten, Anna and Waernbaum, Ingeborg and Schön, Staffan and Gudbjörnsdottir, Soffia and Landin-Olsson, Mona and Dahlquist, Gisela},
  issn         = {0149-5992},
  language     = {eng},
  number       = {1},
  pages        = {27--31},
  publisher    = {American Diabetes Association},
  series       = {Diabetes Care},
  title        = {Decreasing cumulative incidence of end-stage renal disease in young patients with type 1 diabetes in Sweden : A 38-year prospective nationwide study},
  url          = {http://dx.doi.org/10.2337/dc18-1276},
  volume       = {42},
  year         = {2019},
}