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New propranolol analogues: binding and chiral discrimination by cellobiohydrolase Cel7A

Fagerström, Alexandra LU ; Nilsson, Mikael; Berg, Ulf LU and Isaksson, Roland LU (2006) In Organic and Biomolecular Chemistry 4(16). p.3067-3076
Abstract
Novel propranolol analogues have been designed and synthesised and their enantioselective binding to the cellulose degrading enzyme, Cel7A, has been evaluated. Affinity and enantioselectivity have been determined by capillary electrophoresis experiments. Ligands with significantly improved affinity and selectivity have been obtained and an analysis of the results has led to insights concerning the relation between the changes in ligand structure and selectivity as well as affinity to the protein.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Organic and Biomolecular Chemistry
volume
4
issue
16
pages
3067 - 3076
publisher
Royal Society of Chemistry
external identifiers
  • pmid:16886073
  • wos:000239508100008
  • scopus:33746905114
ISSN
1477-0539
DOI
10.1039/b605603b
language
English
LU publication?
yes
id
e072d00c-1e1e-4950-acbd-655c7e0304ad (old id 399031)
date added to LUP
2007-10-02 19:22:46
date last changed
2019-02-20 04:40:12
@article{e072d00c-1e1e-4950-acbd-655c7e0304ad,
  abstract     = {Novel propranolol analogues have been designed and synthesised and their enantioselective binding to the cellulose degrading enzyme, Cel7A, has been evaluated. Affinity and enantioselectivity have been determined by capillary electrophoresis experiments. Ligands with significantly improved affinity and selectivity have been obtained and an analysis of the results has led to insights concerning the relation between the changes in ligand structure and selectivity as well as affinity to the protein.},
  author       = {Fagerström, Alexandra and Nilsson, Mikael and Berg, Ulf and Isaksson, Roland},
  issn         = {1477-0539},
  language     = {eng},
  number       = {16},
  pages        = {3067--3076},
  publisher    = {Royal Society of Chemistry},
  series       = {Organic and Biomolecular Chemistry},
  title        = {New propranolol analogues: binding and chiral discrimination by cellobiohydrolase Cel7A},
  url          = {http://dx.doi.org/10.1039/b605603b},
  volume       = {4},
  year         = {2006},
}