Protective effects of simvastatin on coronary artery function in swine with acute infection.
Liuba, Petru LU ; Pesonen, Erkki LU ; Forslid, Anders LU
; Paakkari, Ilari
; Kornerup-Hansen, Axel
; Kovanen, Petri
; Pentikäinen, Markku
; Persson, Kenneth
LU
and Ostergård, Grete
(2006)
In Atherosclerosis
186(2).
p.331-336
- Abstract
- Background: The risk for coronary events may rise during acute infection. Perturbation in coronary endothelial function emerges as one important link. We investigated whether simvastatin could protect the coronary arterial function from the adverse effects of acute infection in swine. Methods: Coronary endothelium-dependent and -independent vasomotor responses were assessed by Doppler velocimetry in 12 Chlamydia pneunioniae-infected and 6 sham-infected swine 2 weeks after intratracheal inoculation. Half of animals from the infection group were pretreated with simvastatin (80 mg daily), while the remaining animals received placebo. The treatment was started 2 weeks prior to inoculation and Continued until the end of the Study. ANOVA was... (More)
- Background: The risk for coronary events may rise during acute infection. Perturbation in coronary endothelial function emerges as one important link. We investigated whether simvastatin could protect the coronary arterial function from the adverse effects of acute infection in swine. Methods: Coronary endothelium-dependent and -independent vasomotor responses were assessed by Doppler velocimetry in 12 Chlamydia pneunioniae-infected and 6 sham-infected swine 2 weeks after intratracheal inoculation. Half of animals from the infection group were pretreated with simvastatin (80 mg daily), while the remaining animals received placebo. The treatment was started 2 weeks prior to inoculation and Continued until the end of the Study. ANOVA was used for statistical calculations. Data are mean +/- S.D. Results: All animals inoculated with C. pneumoniae developed IgM antibodies against this organism. As compared to noninfected animals, peak-to-baseline coronary flow velocity (CFV) ratio after bradykinin was significantly decreased in infected animals regardless of statin treatment (1,p=0.01). Intracoronary 10(-6) M acetylcholine caused slight dilatory responses in both noninfected and infected-treated animals (CFV ratio: 1.6 +/- 0.2and 1.4 +/- 0.2, respectively: p > 0.1),while a velocity drop (CFV ratio: 0.7 +/- 0.1; p < 0.01 versus noninfected-infected and treated). indicating constriction, was observed in in fected-non treated animals; 10(-5) M acetylcholine caused vasoconstriction in all animals, with a significantly more prolonged response in the infected-non treated group (p < 0.01). Intracoronary adenosine and SNP induced similar dilatory responses in all groups (p > 0.5). There were no differences in markers of systemic inflammation (fibrinogen, amyloid, and CRP) and lipid profile (HDL, LDL and total cholesterol) between the groups (p > 0.2). Conclusion: Acute infection is associated with impairment of the muscarinic and kinin-related reactivity of coronary circulation. These functional abnormalities are in part prevented by simvastatin through mechanisms unrelated to lipid lowering. (c) 2005 Elsevier Ireland Ltd. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/144663
- author
- Liuba, Petru
LU
; Pesonen, Erkki
LU
; Forslid, Anders
LU
; Paakkari, Ilari
; Kornerup-Hansen, Axel
; Kovanen, Petri
; Pentikäinen, Markku
; Persson, Kenneth
LU
and Ostergård, Grete
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- endothelial function, coronary circulation, statin, infection
- in
- Atherosclerosis
- volume
- 186
- issue
- 2
- pages
- 331 - 336
- publisher
- Elsevier
- external identifiers
-
- wos:000238327800011
- pmid:16223501
- scopus:33646413138
- ISSN
- 1879-1484
- DOI
- 10.1016/j.atherosclerosis.2005.08.017
- language
- English
- LU publication?
- yes
- id
- e0735e69-6750-4688-8ad5-02081c446185 (old id 144663)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16223501&dopt=Abstract
- date added to LUP
- 2016-04-01 11:42:36
- date last changed
- 2022-01-26 17:06:25
@article{e0735e69-6750-4688-8ad5-02081c446185,
abstract = {{Background: The risk for coronary events may rise during acute infection. Perturbation in coronary endothelial function emerges as one important link. We investigated whether simvastatin could protect the coronary arterial function from the adverse effects of acute infection in swine. Methods: Coronary endothelium-dependent and -independent vasomotor responses were assessed by Doppler velocimetry in 12 Chlamydia pneunioniae-infected and 6 sham-infected swine 2 weeks after intratracheal inoculation. Half of animals from the infection group were pretreated with simvastatin (80 mg daily), while the remaining animals received placebo. The treatment was started 2 weeks prior to inoculation and Continued until the end of the Study. ANOVA was used for statistical calculations. Data are mean +/- S.D. Results: All animals inoculated with C. pneumoniae developed IgM antibodies against this organism. As compared to noninfected animals, peak-to-baseline coronary flow velocity (CFV) ratio after bradykinin was significantly decreased in infected animals regardless of statin treatment (1,p=0.01). Intracoronary 10(-6) M acetylcholine caused slight dilatory responses in both noninfected and infected-treated animals (CFV ratio: 1.6 +/- 0.2and 1.4 +/- 0.2, respectively: p > 0.1),while a velocity drop (CFV ratio: 0.7 +/- 0.1; p < 0.01 versus noninfected-infected and treated). indicating constriction, was observed in in fected-non treated animals; 10(-5) M acetylcholine caused vasoconstriction in all animals, with a significantly more prolonged response in the infected-non treated group (p < 0.01). Intracoronary adenosine and SNP induced similar dilatory responses in all groups (p > 0.5). There were no differences in markers of systemic inflammation (fibrinogen, amyloid, and CRP) and lipid profile (HDL, LDL and total cholesterol) between the groups (p > 0.2). Conclusion: Acute infection is associated with impairment of the muscarinic and kinin-related reactivity of coronary circulation. These functional abnormalities are in part prevented by simvastatin through mechanisms unrelated to lipid lowering. (c) 2005 Elsevier Ireland Ltd. All rights reserved.}},
author = {{Liuba, Petru and Pesonen, Erkki and Forslid, Anders and Paakkari, Ilari and Kornerup-Hansen, Axel and Kovanen, Petri and Pentikäinen, Markku and Persson, Kenneth and Ostergård, Grete}},
issn = {{1879-1484}},
keywords = {{endothelial function; coronary circulation; statin; infection}},
language = {{eng}},
number = {{2}},
pages = {{331--336}},
publisher = {{Elsevier}},
series = {{Atherosclerosis}},
title = {{Protective effects of simvastatin on coronary artery function in swine with acute infection.}},
url = {{http://dx.doi.org/10.1016/j.atherosclerosis.2005.08.017}},
doi = {{10.1016/j.atherosclerosis.2005.08.017}},
volume = {{186}},
year = {{2006}},
}