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Protective effects of simvastatin on coronary artery function in swine with acute infection.

Liuba, Petru LU ; Pesonen, Erkki LU ; Forslid, Anders LU ; Paakkari, Ilari; Kornerup-Hansen, Axel; Kovanen, Petri; Pentikäinen, Markku; Persson, Kenneth LU and Ostergård, Grete (2006) In Atherosclerosis 186(2). p.331-336
Abstract
Background: The risk for coronary events may rise during acute infection. Perturbation in coronary endothelial function emerges as one important link. We investigated whether simvastatin could protect the coronary arterial function from the adverse effects of acute infection in swine. Methods: Coronary endothelium-dependent and -independent vasomotor responses were assessed by Doppler velocimetry in 12 Chlamydia pneunioniae-infected and 6 sham-infected swine 2 weeks after intratracheal inoculation. Half of animals from the infection group were pretreated with simvastatin (80 mg daily), while the remaining animals received placebo. The treatment was started 2 weeks prior to inoculation and Continued until the end of the Study. ANOVA was... (More)
Background: The risk for coronary events may rise during acute infection. Perturbation in coronary endothelial function emerges as one important link. We investigated whether simvastatin could protect the coronary arterial function from the adverse effects of acute infection in swine. Methods: Coronary endothelium-dependent and -independent vasomotor responses were assessed by Doppler velocimetry in 12 Chlamydia pneunioniae-infected and 6 sham-infected swine 2 weeks after intratracheal inoculation. Half of animals from the infection group were pretreated with simvastatin (80 mg daily), while the remaining animals received placebo. The treatment was started 2 weeks prior to inoculation and Continued until the end of the Study. ANOVA was used for statistical calculations. Data are mean +/- S.D. Results: All animals inoculated with C. pneumoniae developed IgM antibodies against this organism. As compared to noninfected animals, peak-to-baseline coronary flow velocity (CFV) ratio after bradykinin was significantly decreased in infected animals regardless of statin treatment (1,p=0.01). Intracoronary 10(-6) M acetylcholine caused slight dilatory responses in both noninfected and infected-treated animals (CFV ratio: 1.6 +/- 0.2and 1.4 +/- 0.2, respectively: p > 0.1),while a velocity drop (CFV ratio: 0.7 +/- 0.1; p < 0.01 versus noninfected-infected and treated). indicating constriction, was observed in in fected-non treated animals; 10(-5) M acetylcholine caused vasoconstriction in all animals, with a significantly more prolonged response in the infected-non treated group (p < 0.01). Intracoronary adenosine and SNP induced similar dilatory responses in all groups (p > 0.5). There were no differences in markers of systemic inflammation (fibrinogen, amyloid, and CRP) and lipid profile (HDL, LDL and total cholesterol) between the groups (p > 0.2). Conclusion: Acute infection is associated with impairment of the muscarinic and kinin-related reactivity of coronary circulation. These functional abnormalities are in part prevented by simvastatin through mechanisms unrelated to lipid lowering. (c) 2005 Elsevier Ireland Ltd. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
endothelial function, coronary circulation, statin, infection
in
Atherosclerosis
volume
186
issue
2
pages
331 - 336
publisher
Elsevier
external identifiers
  • wos:000238327800011
  • pmid:16223501
  • scopus:33646413138
ISSN
1879-1484
DOI
10.1016/j.atherosclerosis.2005.08.017
language
English
LU publication?
yes
id
e0735e69-6750-4688-8ad5-02081c446185 (old id 144663)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16223501&dopt=Abstract
date added to LUP
2007-07-23 14:45:00
date last changed
2019-02-20 03:43:09
@article{e0735e69-6750-4688-8ad5-02081c446185,
  abstract     = {Background: The risk for coronary events may rise during acute infection. Perturbation in coronary endothelial function emerges as one important link. We investigated whether simvastatin could protect the coronary arterial function from the adverse effects of acute infection in swine. Methods: Coronary endothelium-dependent and -independent vasomotor responses were assessed by Doppler velocimetry in 12 Chlamydia pneunioniae-infected and 6 sham-infected swine 2 weeks after intratracheal inoculation. Half of animals from the infection group were pretreated with simvastatin (80 mg daily), while the remaining animals received placebo. The treatment was started 2 weeks prior to inoculation and Continued until the end of the Study. ANOVA was used for statistical calculations. Data are mean +/- S.D. Results: All animals inoculated with C. pneumoniae developed IgM antibodies against this organism. As compared to noninfected animals, peak-to-baseline coronary flow velocity (CFV) ratio after bradykinin was significantly decreased in infected animals regardless of statin treatment (1,p=0.01). Intracoronary 10(-6) M acetylcholine caused slight dilatory responses in both noninfected and infected-treated animals (CFV ratio: 1.6 +/- 0.2and 1.4 +/- 0.2, respectively: p &gt; 0.1),while a velocity drop (CFV ratio: 0.7 +/- 0.1; p &lt; 0.01 versus noninfected-infected and treated). indicating constriction, was observed in in fected-non treated animals; 10(-5) M acetylcholine caused vasoconstriction in all animals, with a significantly more prolonged response in the infected-non treated group (p &lt; 0.01). Intracoronary adenosine and SNP induced similar dilatory responses in all groups (p &gt; 0.5). There were no differences in markers of systemic inflammation (fibrinogen, amyloid, and CRP) and lipid profile (HDL, LDL and total cholesterol) between the groups (p &gt; 0.2). Conclusion: Acute infection is associated with impairment of the muscarinic and kinin-related reactivity of coronary circulation. These functional abnormalities are in part prevented by simvastatin through mechanisms unrelated to lipid lowering. (c) 2005 Elsevier Ireland Ltd. All rights reserved.},
  author       = {Liuba, Petru and Pesonen, Erkki and Forslid, Anders and Paakkari, Ilari and Kornerup-Hansen, Axel and Kovanen, Petri and Pentikäinen, Markku and Persson, Kenneth and Ostergård, Grete},
  issn         = {1879-1484},
  keyword      = {endothelial function,coronary circulation,statin,infection},
  language     = {eng},
  number       = {2},
  pages        = {331--336},
  publisher    = {Elsevier},
  series       = {Atherosclerosis},
  title        = {Protective effects of simvastatin on coronary artery function in swine with acute infection.},
  url          = {http://dx.doi.org/10.1016/j.atherosclerosis.2005.08.017},
  volume       = {186},
  year         = {2006},
}