Effect of Neprilysin Inhibition on Alzheimer Disease Plasma Biomarkers : A Secondary Analysis of a Randomized Clinical Trial
(2024) In JAMA Neurology- Abstract
- Amyloid-β (Aβ) accumulation is critical in Alzheimer disease (AD), and neprilysin is involved in physiologically clearing Aβ. Concerns exist regarding long-term use of sacubitril/valsartan, a neprilysin inhibitor and angiotensin receptor blocker used for heart failure, and its potential to increase AD risk. We evaluated neprilysin inhibition’s effect on AD blood biomarkers in patients with coronary heart disease.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/e07ae7ef-337e-4453-afce-256d6cfd3dfb
- author
- Brum, Wagner S. ; Docherty, Kieran F. ; Ashton, Nicholas J. ; Zetterberg, Henrik LU ; Hansson, Oskar LU ; McMurray, John J.V. and Blennow, Kaj LU
- organization
- publishing date
- 2024
- type
- Contribution to journal
- publication status
- epub
- subject
- in
- JAMA Neurology
- publisher
- American Medical Association
- external identifiers
-
- pmid:38109077
- scopus:85181027456
- ISSN
- 2168-6149
- DOI
- 10.1001/jamaneurol.2023.4719
- language
- English
- LU publication?
- yes
- id
- e07ae7ef-337e-4453-afce-256d6cfd3dfb
- date added to LUP
- 2024-02-07 15:37:52
- date last changed
- 2024-04-23 22:28:17
@article{e07ae7ef-337e-4453-afce-256d6cfd3dfb, abstract = {{Amyloid-β (Aβ) accumulation is critical in Alzheimer disease (AD), and neprilysin is involved in physiologically clearing Aβ. Concerns exist regarding long-term use of sacubitril/valsartan, a neprilysin inhibitor and angiotensin receptor blocker used for heart failure, and its potential to increase AD risk. We evaluated neprilysin inhibition’s effect on AD blood biomarkers in patients with coronary heart disease.}}, author = {{Brum, Wagner S. and Docherty, Kieran F. and Ashton, Nicholas J. and Zetterberg, Henrik and Hansson, Oskar and McMurray, John J.V. and Blennow, Kaj}}, issn = {{2168-6149}}, language = {{eng}}, publisher = {{American Medical Association}}, series = {{JAMA Neurology}}, title = {{Effect of Neprilysin Inhibition on Alzheimer Disease Plasma Biomarkers : A Secondary Analysis of a Randomized Clinical Trial}}, url = {{http://dx.doi.org/10.1001/jamaneurol.2023.4719}}, doi = {{10.1001/jamaneurol.2023.4719}}, year = {{2024}}, }