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Effect of Neprilysin Inhibition on Alzheimer Disease Plasma Biomarkers : A Secondary Analysis of a Randomized Clinical Trial

Brum, Wagner S. ; Docherty, Kieran F. ; Ashton, Nicholas J. ; Zetterberg, Henrik LU ; Hansson, Oskar LU orcid ; McMurray, John J.V. and Blennow, Kaj LU (2024) In JAMA Neurology
Abstract
Amyloid-β (Aβ) accumulation is critical in Alzheimer disease (AD), and neprilysin is involved in physiologically clearing Aβ. Concerns exist regarding long-term use of sacubitril/valsartan, a neprilysin inhibitor and angiotensin receptor blocker used for heart failure, and its potential to increase AD risk. We evaluated neprilysin inhibition’s effect on AD blood biomarkers in patients with coronary heart disease.
Please use this url to cite or link to this publication:
author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
epub
subject
in
JAMA Neurology
publisher
American Medical Association
external identifiers
  • pmid:38109077
  • scopus:85181027456
ISSN
2168-6149
DOI
10.1001/jamaneurol.2023.4719
language
English
LU publication?
yes
id
e07ae7ef-337e-4453-afce-256d6cfd3dfb
date added to LUP
2024-02-07 15:37:52
date last changed
2024-04-23 22:28:17
@article{e07ae7ef-337e-4453-afce-256d6cfd3dfb,
  abstract     = {{Amyloid-β (Aβ) accumulation is critical in Alzheimer disease (AD), and neprilysin is involved in physiologically clearing Aβ. Concerns exist regarding long-term use of sacubitril/valsartan, a neprilysin inhibitor and angiotensin receptor blocker used for heart failure, and its potential to increase AD risk. We evaluated neprilysin inhibition’s effect on AD blood biomarkers in patients with coronary heart disease.}},
  author       = {{Brum, Wagner S. and Docherty, Kieran F. and Ashton, Nicholas J. and Zetterberg, Henrik and Hansson, Oskar and McMurray, John J.V. and Blennow, Kaj}},
  issn         = {{2168-6149}},
  language     = {{eng}},
  publisher    = {{American Medical Association}},
  series       = {{JAMA Neurology}},
  title        = {{Effect of Neprilysin Inhibition on Alzheimer Disease Plasma Biomarkers : A Secondary Analysis of a Randomized Clinical Trial}},
  url          = {{http://dx.doi.org/10.1001/jamaneurol.2023.4719}},
  doi          = {{10.1001/jamaneurol.2023.4719}},
  year         = {{2024}},
}