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Parvovirus B19 infection in pregnancy and subsequent morbidity and mortality in offspring

Lassen, Jonathan; Bager, Peter; Wohlfahrt, Jan; Böttiger, Blenda LU and Melbye, Mads (2013) In International Journal of Epidemiology 42(4). p.6-1070
Abstract

BACKGROUND: Because parvovirus B19 infection in pregnancy has been associated with infant morbidity and mortality in case reports and after intrauterine transfusion, we tested the population-based association using serum and hospital data of high quality.

METHODS: We established a cohort of 113 228 children born to women tested for parvovirus B19 infection during pregnancy in a major diagnostic laboratory in Denmark, from 1994 to 2009. Information on 20 selected morbidity diagnoses and on mortality was obtained from the Danish National Patient Register, the Danish Cancer Register and the Danish Civil Registration System. Incidence rate ratios (IRR) were estimated by log-linear Poisson regression with adjustment for age and sex of... (More)

BACKGROUND: Because parvovirus B19 infection in pregnancy has been associated with infant morbidity and mortality in case reports and after intrauterine transfusion, we tested the population-based association using serum and hospital data of high quality.

METHODS: We established a cohort of 113 228 children born to women tested for parvovirus B19 infection during pregnancy in a major diagnostic laboratory in Denmark, from 1994 to 2009. Information on 20 selected morbidity diagnoses and on mortality was obtained from the Danish National Patient Register, the Danish Cancer Register and the Danish Civil Registration System. Incidence rate ratios (IRR) were estimated by log-linear Poisson regression with adjustment for age and sex of the child, maternal age and year of maternal parvovirus B19 test.

RESULTS: A total of 1095 (1.0%) children were born to mothers who were infected with parvovirus B19 during pregnancy. During 1 million person-years of follow-up, 10 856 children experienced morbidity and 590 children died. Overall, maternal infection status was neither associated with morbidity during infancy (IRR 0.64; 95% CI: 0.40 to 1.02) or childhood (IRR 0.93; 95% CI: 0.77 to 1.14), nor with infant mortality (IRR 0.98; 95% CI: 0.44 to 2.20). Specifically, there was no association with 19 of 20 morbidities. An excess risk of cancer in the central nervous system was observed (IRR 5.88; 95% CI: 1.41 to 24.6); however, the number of exposed cases was very small (n = 2).

CONCLUSIONS: Parvovirus B19 infection during pregnancy was not associated with overall morbidity or mortality in infancy and childhood.

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Contribution to journal
publication status
published
keywords
Adolescent, Adult, Child, Child, Preschool, Denmark/epidemiology, Epidemiologic Methods, Female, Humans, Infant, Infant, Newborn, Maternal Age, Middle Aged, Parvoviridae Infections/mortality, Parvovirus B19, Human, Pregnancy, Pregnancy Complications, Infectious/mortality, Prenatal Exposure Delayed Effects/mortality, Young Adult
in
International Journal of Epidemiology
volume
42
issue
4
pages
6 - 1070
publisher
Oxford University Press
external identifiers
  • scopus:84884761041
ISSN
1464-3685
DOI
10.1093/ije/dyt117
language
English
LU publication?
no
id
e08d175b-65bd-4e49-81f9-8cccd63b5aa2
date added to LUP
2019-05-02 14:16:01
date last changed
2019-10-13 05:00:47
@article{e08d175b-65bd-4e49-81f9-8cccd63b5aa2,
  abstract     = {<p>BACKGROUND: Because parvovirus B19 infection in pregnancy has been associated with infant morbidity and mortality in case reports and after intrauterine transfusion, we tested the population-based association using serum and hospital data of high quality.</p><p>METHODS: We established a cohort of 113 228 children born to women tested for parvovirus B19 infection during pregnancy in a major diagnostic laboratory in Denmark, from 1994 to 2009. Information on 20 selected morbidity diagnoses and on mortality was obtained from the Danish National Patient Register, the Danish Cancer Register and the Danish Civil Registration System. Incidence rate ratios (IRR) were estimated by log-linear Poisson regression with adjustment for age and sex of the child, maternal age and year of maternal parvovirus B19 test.</p><p>RESULTS: A total of 1095 (1.0%) children were born to mothers who were infected with parvovirus B19 during pregnancy. During 1 million person-years of follow-up, 10 856 children experienced morbidity and 590 children died. Overall, maternal infection status was neither associated with morbidity during infancy (IRR 0.64; 95% CI: 0.40 to 1.02) or childhood (IRR 0.93; 95% CI: 0.77 to 1.14), nor with infant mortality (IRR 0.98; 95% CI: 0.44 to 2.20). Specifically, there was no association with 19 of 20 morbidities. An excess risk of cancer in the central nervous system was observed (IRR 5.88; 95% CI: 1.41 to 24.6); however, the number of exposed cases was very small (n = 2).</p><p>CONCLUSIONS: Parvovirus B19 infection during pregnancy was not associated with overall morbidity or mortality in infancy and childhood.</p>},
  author       = {Lassen, Jonathan and Bager, Peter and Wohlfahrt, Jan and Böttiger, Blenda and Melbye, Mads},
  issn         = {1464-3685},
  keyword      = {Adolescent,Adult,Child,Child, Preschool,Denmark/epidemiology,Epidemiologic Methods,Female,Humans,Infant,Infant, Newborn,Maternal Age,Middle Aged,Parvoviridae Infections/mortality,Parvovirus B19, Human,Pregnancy,Pregnancy Complications, Infectious/mortality,Prenatal Exposure Delayed Effects/mortality,Young Adult},
  language     = {eng},
  number       = {4},
  pages        = {6--1070},
  publisher    = {Oxford University Press},
  series       = {International Journal of Epidemiology},
  title        = {Parvovirus B19 infection in pregnancy and subsequent morbidity and mortality in offspring},
  url          = {http://dx.doi.org/10.1093/ije/dyt117},
  volume       = {42},
  year         = {2013},
}