Experimental hyperthyroidism in man: effects on plasma lipoproteins, lipoprotein lipase and hepatic lipase
(1983) In Hormone and Metabolic Research 15(9). p.449-452- Abstract
- We have studied the effects of triiodothyronine administration (20-40 micrograms three times daily over one week) in six healthy young men, on the activities of lipoprotein lipase and hepatic lipase and on plasma lipoprotein concentrations. Hepatic lipase activity in post-heparin plasma rose by 46 +/- 25% (p less than 0.025), whereas the activity of lipoprotein lipase did not change significantly. Plasma cholesterol concentrations decreased by about 20% (p less than 0.025), whereas there was no change in plasma triglyceride levels. The fall in plasma cholesterol could be accounted for by a reduction of HDL cholesterol (-11%, p less than 0.025) as well as LDL cholesterol (-27%, p less than 0.025). The data emphasize the role of hepatic... (More)
- We have studied the effects of triiodothyronine administration (20-40 micrograms three times daily over one week) in six healthy young men, on the activities of lipoprotein lipase and hepatic lipase and on plasma lipoprotein concentrations. Hepatic lipase activity in post-heparin plasma rose by 46 +/- 25% (p less than 0.025), whereas the activity of lipoprotein lipase did not change significantly. Plasma cholesterol concentrations decreased by about 20% (p less than 0.025), whereas there was no change in plasma triglyceride levels. The fall in plasma cholesterol could be accounted for by a reduction of HDL cholesterol (-11%, p less than 0.025) as well as LDL cholesterol (-27%, p less than 0.025). The data emphasize the role of hepatic lipase in the lipoprotein alterations associated with thyroid dysfunction. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1103133
- author
- Hansson, P ; Valdemarsson, Stig LU and Nilsson-Ehle, Peter LU
- organization
- publishing date
- 1983
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Hormone and Metabolic Research
- volume
- 15
- issue
- 9
- pages
- 449 - 452
- publisher
- Georg Thieme Verlag
- external identifiers
-
- pmid:6642415
- scopus:0020514551
- ISSN
- 1439-4286
- language
- English
- LU publication?
- yes
- id
- e0917a6e-746e-465f-8dff-fbeae037bfe9 (old id 1103133)
- date added to LUP
- 2016-04-01 15:24:22
- date last changed
- 2024-01-10 14:45:12
@article{e0917a6e-746e-465f-8dff-fbeae037bfe9,
abstract = {{We have studied the effects of triiodothyronine administration (20-40 micrograms three times daily over one week) in six healthy young men, on the activities of lipoprotein lipase and hepatic lipase and on plasma lipoprotein concentrations. Hepatic lipase activity in post-heparin plasma rose by 46 +/- 25% (p less than 0.025), whereas the activity of lipoprotein lipase did not change significantly. Plasma cholesterol concentrations decreased by about 20% (p less than 0.025), whereas there was no change in plasma triglyceride levels. The fall in plasma cholesterol could be accounted for by a reduction of HDL cholesterol (-11%, p less than 0.025) as well as LDL cholesterol (-27%, p less than 0.025). The data emphasize the role of hepatic lipase in the lipoprotein alterations associated with thyroid dysfunction.}},
author = {{Hansson, P and Valdemarsson, Stig and Nilsson-Ehle, Peter}},
issn = {{1439-4286}},
language = {{eng}},
number = {{9}},
pages = {{449--452}},
publisher = {{Georg Thieme Verlag}},
series = {{Hormone and Metabolic Research}},
title = {{Experimental hyperthyroidism in man: effects on plasma lipoproteins, lipoprotein lipase and hepatic lipase}},
volume = {{15}},
year = {{1983}},
}