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Autoimmune disease is associated with a lower risk of progression in monoclonal gammopathy of undetermined significance

Baldursdóttir, Theodóra Rún ; Löve, Þorvarður Jón ; Gíslason, Gauti Kjartan ; Björkholm, Magnus ; Mellqvist, Ulf Henrik ; Lund, Sigrun Helga ; Blimark, Cecilie Hveding ; Turesson, Ingemar LU ; Hultcrantz, Malin and Landgren, Ola , et al. (2021) In European Journal of Haematology 106(3). p.380-388
Abstract

Objectives and methods: We conducted a population-based study including 19 303 individuals diagnosed with MGUS in Sweden from 1985 to 2013, with the aim to determine whether a prior history of autoimmune disease, a well-described risk factor for MGUS is a risk factor for progression of MGUS to multiple myeloma (MM) or lymphoproliferative diseases (LPs). Using the nationwide Swedish Patient registry, we identified MGUS cases with versus without an autoimmune disease present at the time of MGUS diagnosis and estimated their risk of progression. Results: A total of 5612 (29.1%) MGUS cases had preceding autoimmune diseases. Using Cox proportional hazards models, we found the risk of progression from MGUS to MM (HR = 0.83, 95% CI 0.73-0.94)... (More)

Objectives and methods: We conducted a population-based study including 19 303 individuals diagnosed with MGUS in Sweden from 1985 to 2013, with the aim to determine whether a prior history of autoimmune disease, a well-described risk factor for MGUS is a risk factor for progression of MGUS to multiple myeloma (MM) or lymphoproliferative diseases (LPs). Using the nationwide Swedish Patient registry, we identified MGUS cases with versus without an autoimmune disease present at the time of MGUS diagnosis and estimated their risk of progression. Results: A total of 5612 (29.1%) MGUS cases had preceding autoimmune diseases. Using Cox proportional hazards models, we found the risk of progression from MGUS to MM (HR = 0.83, 95% CI 0.73-0.94) and LPs (HR = 0.84, 95% CI 0.75-0.94) to be significantly lower in MGUS cases with prior autoimmune disease (compared to MGUS cases without). Conclusions: In this large population-based study, a history of autoimmune disease was associated with a reduced risk of progression from MGUS to MM/other LPs. Potential underlying reason is that MGUS caused by chronic antigen stimulation is biologically less likely to undergo the genetic events that trigger progression. Our results may have implications in clinical counseling for patients with MGUS and underlying autoimmune disease.

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publishing date
type
Contribution to journal
publication status
published
subject
keywords
autoimmune disease, lymphoproliferative, monoclonal gammopathy of undetermined significance, multiple myeloma, population-based
in
European Journal of Haematology
volume
106
issue
3
pages
380 - 388
publisher
Wiley-Blackwell
external identifiers
  • scopus:85098223811
  • pmid:33295006
ISSN
0902-4441
DOI
10.1111/ejh.13563
language
English
LU publication?
no
id
e0960785-e924-4fa3-acec-4c64149e22ac
date added to LUP
2021-01-11 13:05:50
date last changed
2024-02-17 11:54:38
@article{e0960785-e924-4fa3-acec-4c64149e22ac,
  abstract     = {{<p>Objectives and methods: We conducted a population-based study including 19 303 individuals diagnosed with MGUS in Sweden from 1985 to 2013, with the aim to determine whether a prior history of autoimmune disease, a well-described risk factor for MGUS is a risk factor for progression of MGUS to multiple myeloma (MM) or lymphoproliferative diseases (LPs). Using the nationwide Swedish Patient registry, we identified MGUS cases with versus without an autoimmune disease present at the time of MGUS diagnosis and estimated their risk of progression. Results: A total of 5612 (29.1%) MGUS cases had preceding autoimmune diseases. Using Cox proportional hazards models, we found the risk of progression from MGUS to MM (HR = 0.83, 95% CI 0.73-0.94) and LPs (HR = 0.84, 95% CI 0.75-0.94) to be significantly lower in MGUS cases with prior autoimmune disease (compared to MGUS cases without). Conclusions: In this large population-based study, a history of autoimmune disease was associated with a reduced risk of progression from MGUS to MM/other LPs. Potential underlying reason is that MGUS caused by chronic antigen stimulation is biologically less likely to undergo the genetic events that trigger progression. Our results may have implications in clinical counseling for patients with MGUS and underlying autoimmune disease.</p>}},
  author       = {{Baldursdóttir, Theodóra Rún and Löve, Þorvarður Jón and Gíslason, Gauti Kjartan and Björkholm, Magnus and Mellqvist, Ulf Henrik and Lund, Sigrun Helga and Blimark, Cecilie Hveding and Turesson, Ingemar and Hultcrantz, Malin and Landgren, Ola and Kristinsson, Sigurður Yngvi}},
  issn         = {{0902-4441}},
  keywords     = {{autoimmune disease; lymphoproliferative; monoclonal gammopathy of undetermined significance; multiple myeloma; population-based}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{380--388}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{European Journal of Haematology}},
  title        = {{Autoimmune disease is associated with a lower risk of progression in monoclonal gammopathy of undetermined significance}},
  url          = {{http://dx.doi.org/10.1111/ejh.13563}},
  doi          = {{10.1111/ejh.13563}},
  volume       = {{106}},
  year         = {{2021}},
}