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Ovarian cancer-associated mesothelial cells : Transdifferentiation to minions of cancer and orchestrate developing peritoneal dissemination

Mogi, Kazumasa ; Yoshihara, Masato ; Iyoshi, Shohei ; Kitami, Kazuhisa ; Uno, Kaname LU orcid ; Tano, Sho ; Koya, Yoshihiro ; Sugiyama, Mai ; Yamakita, Yoshihiko and Nawa, Akihiro , et al. (2021) In Cancers 13(6).
Abstract

Ovarian cancer has one of the poorest prognoses among carcinomas. Advanced ovarian cancer often develops ascites and peritoneal dissemination, which is one of the poor prognostic factors. From the perspective of the “seed and soil” hypothesis, the intra-abdominal environment is like the soil for the growth of ovarian cancer (OvCa) and mesothelial cells (MCs) line the top layer of this soil. In recent years, various functions of MCs have been reported, including supporting cancer in the OvCa microenvironment. We refer to OvCa-associated MCs (OCAMs) as MCs that are stimulated by OvCa and contribute to its progression. OCAMs promote OvCa cell adhesion to the peritoneum, invasion, and metastasis. Elucidation of these functions may lead to... (More)

Ovarian cancer has one of the poorest prognoses among carcinomas. Advanced ovarian cancer often develops ascites and peritoneal dissemination, which is one of the poor prognostic factors. From the perspective of the “seed and soil” hypothesis, the intra-abdominal environment is like the soil for the growth of ovarian cancer (OvCa) and mesothelial cells (MCs) line the top layer of this soil. In recent years, various functions of MCs have been reported, including supporting cancer in the OvCa microenvironment. We refer to OvCa-associated MCs (OCAMs) as MCs that are stimulated by OvCa and contribute to its progression. OCAMs promote OvCa cell adhesion to the peritoneum, invasion, and metastasis. Elucidation of these functions may lead to the identification of novel therapeutic targets that can delay OvCa progression, which is difficult to cure.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Epithelial mesenchymal transition, Mesothelial cells, Ovarian cancer, Peritoneal dissemination, Tumor microenvironment
in
Cancers
volume
13
issue
6
article number
1352
pages
13 pages
publisher
MDPI AG
external identifiers
  • scopus:85102565976
  • pmid:33802781
ISSN
2072-6694
DOI
10.3390/cancers13061352
language
English
LU publication?
yes
id
e0967ab9-de3f-4ac7-a4c2-3a8ecd914b19
date added to LUP
2021-03-24 12:58:03
date last changed
2024-06-13 09:11:03
@article{e0967ab9-de3f-4ac7-a4c2-3a8ecd914b19,
  abstract     = {{<p>Ovarian cancer has one of the poorest prognoses among carcinomas. Advanced ovarian cancer often develops ascites and peritoneal dissemination, which is one of the poor prognostic factors. From the perspective of the “seed and soil” hypothesis, the intra-abdominal environment is like the soil for the growth of ovarian cancer (OvCa) and mesothelial cells (MCs) line the top layer of this soil. In recent years, various functions of MCs have been reported, including supporting cancer in the OvCa microenvironment. We refer to OvCa-associated MCs (OCAMs) as MCs that are stimulated by OvCa and contribute to its progression. OCAMs promote OvCa cell adhesion to the peritoneum, invasion, and metastasis. Elucidation of these functions may lead to the identification of novel therapeutic targets that can delay OvCa progression, which is difficult to cure.</p>}},
  author       = {{Mogi, Kazumasa and Yoshihara, Masato and Iyoshi, Shohei and Kitami, Kazuhisa and Uno, Kaname and Tano, Sho and Koya, Yoshihiro and Sugiyama, Mai and Yamakita, Yoshihiko and Nawa, Akihiro and Tomita, Hiroyuki and Kajiyama, Hiroaki}},
  issn         = {{2072-6694}},
  keywords     = {{Epithelial mesenchymal transition; Mesothelial cells; Ovarian cancer; Peritoneal dissemination; Tumor microenvironment}},
  language     = {{eng}},
  number       = {{6}},
  publisher    = {{MDPI AG}},
  series       = {{Cancers}},
  title        = {{Ovarian cancer-associated mesothelial cells : Transdifferentiation to minions of cancer and orchestrate developing peritoneal dissemination}},
  url          = {{http://dx.doi.org/10.3390/cancers13061352}},
  doi          = {{10.3390/cancers13061352}},
  volume       = {{13}},
  year         = {{2021}},
}