Ovarian cancer-associated mesothelial cells : Transdifferentiation to minions of cancer and orchestrate developing peritoneal dissemination
(2021) In Cancers 13(6).- Abstract
Ovarian cancer has one of the poorest prognoses among carcinomas. Advanced ovarian cancer often develops ascites and peritoneal dissemination, which is one of the poor prognostic factors. From the perspective of the “seed and soil” hypothesis, the intra-abdominal environment is like the soil for the growth of ovarian cancer (OvCa) and mesothelial cells (MCs) line the top layer of this soil. In recent years, various functions of MCs have been reported, including supporting cancer in the OvCa microenvironment. We refer to OvCa-associated MCs (OCAMs) as MCs that are stimulated by OvCa and contribute to its progression. OCAMs promote OvCa cell adhesion to the peritoneum, invasion, and metastasis. Elucidation of these functions may lead to... (More)
Ovarian cancer has one of the poorest prognoses among carcinomas. Advanced ovarian cancer often develops ascites and peritoneal dissemination, which is one of the poor prognostic factors. From the perspective of the “seed and soil” hypothesis, the intra-abdominal environment is like the soil for the growth of ovarian cancer (OvCa) and mesothelial cells (MCs) line the top layer of this soil. In recent years, various functions of MCs have been reported, including supporting cancer in the OvCa microenvironment. We refer to OvCa-associated MCs (OCAMs) as MCs that are stimulated by OvCa and contribute to its progression. OCAMs promote OvCa cell adhesion to the peritoneum, invasion, and metastasis. Elucidation of these functions may lead to the identification of novel therapeutic targets that can delay OvCa progression, which is difficult to cure.
(Less)
- author
- organization
- publishing date
- 2021
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Epithelial mesenchymal transition, Mesothelial cells, Ovarian cancer, Peritoneal dissemination, Tumor microenvironment
- in
- Cancers
- volume
- 13
- issue
- 6
- article number
- 1352
- pages
- 13 pages
- publisher
- MDPI AG
- external identifiers
-
- scopus:85102565976
- pmid:33802781
- ISSN
- 2072-6694
- DOI
- 10.3390/cancers13061352
- language
- English
- LU publication?
- yes
- id
- e0967ab9-de3f-4ac7-a4c2-3a8ecd914b19
- date added to LUP
- 2021-03-24 12:58:03
- date last changed
- 2024-06-13 09:11:03
@article{e0967ab9-de3f-4ac7-a4c2-3a8ecd914b19, abstract = {{<p>Ovarian cancer has one of the poorest prognoses among carcinomas. Advanced ovarian cancer often develops ascites and peritoneal dissemination, which is one of the poor prognostic factors. From the perspective of the “seed and soil” hypothesis, the intra-abdominal environment is like the soil for the growth of ovarian cancer (OvCa) and mesothelial cells (MCs) line the top layer of this soil. In recent years, various functions of MCs have been reported, including supporting cancer in the OvCa microenvironment. We refer to OvCa-associated MCs (OCAMs) as MCs that are stimulated by OvCa and contribute to its progression. OCAMs promote OvCa cell adhesion to the peritoneum, invasion, and metastasis. Elucidation of these functions may lead to the identification of novel therapeutic targets that can delay OvCa progression, which is difficult to cure.</p>}}, author = {{Mogi, Kazumasa and Yoshihara, Masato and Iyoshi, Shohei and Kitami, Kazuhisa and Uno, Kaname and Tano, Sho and Koya, Yoshihiro and Sugiyama, Mai and Yamakita, Yoshihiko and Nawa, Akihiro and Tomita, Hiroyuki and Kajiyama, Hiroaki}}, issn = {{2072-6694}}, keywords = {{Epithelial mesenchymal transition; Mesothelial cells; Ovarian cancer; Peritoneal dissemination; Tumor microenvironment}}, language = {{eng}}, number = {{6}}, publisher = {{MDPI AG}}, series = {{Cancers}}, title = {{Ovarian cancer-associated mesothelial cells : Transdifferentiation to minions of cancer and orchestrate developing peritoneal dissemination}}, url = {{http://dx.doi.org/10.3390/cancers13061352}}, doi = {{10.3390/cancers13061352}}, volume = {{13}}, year = {{2021}}, }