Metformin Attenuates Early-Stage Atherosclerosis in Mildly Hyperglycemic Oikawa-Nagao Mice
(2019) In Journal of Atherosclerosis and Thrombosis 26(12). p.1075-1083- Abstract
AIM: Although metformin treatment has been reported to reduce the risk of cardiovascular events in patients with type 2 diabetes, the underlying mechanisms have not been elucidated fully. Here we assessed atherosclerotic lesion formation in newly established 2 mouse lines with different blood glucose levels (Oikawa-Nagao Diabetes-Prone [ON-DP] and -Resistant [ON-DR]) to evaluate the effect of metformin on early-stage atherosclerosis.
METHODS: Mildly hyperglycemic ON-DP and normoglycemic ON-DR female mice fed an atherogenic diet for 20 weeks (8-28 weeks of age). During the feeding period, one group of each mouse line received metformin in drinking water (0.1%), while another group received water alone as control. Atherosclerotic... (More)
AIM: Although metformin treatment has been reported to reduce the risk of cardiovascular events in patients with type 2 diabetes, the underlying mechanisms have not been elucidated fully. Here we assessed atherosclerotic lesion formation in newly established 2 mouse lines with different blood glucose levels (Oikawa-Nagao Diabetes-Prone [ON-DP] and -Resistant [ON-DR]) to evaluate the effect of metformin on early-stage atherosclerosis.
METHODS: Mildly hyperglycemic ON-DP and normoglycemic ON-DR female mice fed an atherogenic diet for 20 weeks (8-28 weeks of age). During the feeding period, one group of each mouse line received metformin in drinking water (0.1%), while another group received water alone as control. Atherosclerotic lesion formation in the aortic sinus was quantitively analyzed from the oil red O-stained area of the serial sections.
RESULTS: Metformin treatment did not affect food intake, body weight, and casual blood glucose levels within each mouse line during the 20-week feeding period. Nevertheless, metformin treatment significantly reduced atherosclerotic lesion formation in the ON-DP mice (59% of control), whereas no significant effect of metformin was observed in the lesion size of the ON-DR mice.
CONCLUSION: Metformin can attenuate early-stage atherogenesis in mildly hyperglycemic ON-DP mice. Pleiotropic effects of metformin, beyond its glucose-lowering action, may contribute to the antiatherogenic property in the early-stage atherosclerosis.
(Less)
- author
- Asai, Akira LU ; Shuto, Yuki ; Nagao, Mototsugu LU ; Kawahara, Momoyo ; Miyazawa, Teruo ; Sugihara, Hitoshi and Oikawa, Shinichi
- publishing date
- 2019-12-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Atherosclerosis and Thrombosis
- volume
- 26
- issue
- 12
- pages
- 9 pages
- publisher
- Japan Atherosclerosis Society
- external identifiers
-
- pmid:30971640
- scopus:85075859803
- ISSN
- 1880-3873
- DOI
- 10.5551/jat.48223
- language
- English
- LU publication?
- no
- id
- e0b0e3ad-43c3-4ae1-bcb9-a7036d27ce9b
- date added to LUP
- 2020-03-05 15:46:17
- date last changed
- 2024-05-29 10:33:50
@article{e0b0e3ad-43c3-4ae1-bcb9-a7036d27ce9b,
abstract = {{<p>AIM: Although metformin treatment has been reported to reduce the risk of cardiovascular events in patients with type 2 diabetes, the underlying mechanisms have not been elucidated fully. Here we assessed atherosclerotic lesion formation in newly established 2 mouse lines with different blood glucose levels (Oikawa-Nagao Diabetes-Prone [ON-DP] and -Resistant [ON-DR]) to evaluate the effect of metformin on early-stage atherosclerosis.</p><p>METHODS: Mildly hyperglycemic ON-DP and normoglycemic ON-DR female mice fed an atherogenic diet for 20 weeks (8-28 weeks of age). During the feeding period, one group of each mouse line received metformin in drinking water (0.1%), while another group received water alone as control. Atherosclerotic lesion formation in the aortic sinus was quantitively analyzed from the oil red O-stained area of the serial sections.</p><p>RESULTS: Metformin treatment did not affect food intake, body weight, and casual blood glucose levels within each mouse line during the 20-week feeding period. Nevertheless, metformin treatment significantly reduced atherosclerotic lesion formation in the ON-DP mice (59% of control), whereas no significant effect of metformin was observed in the lesion size of the ON-DR mice.</p><p>CONCLUSION: Metformin can attenuate early-stage atherogenesis in mildly hyperglycemic ON-DP mice. Pleiotropic effects of metformin, beyond its glucose-lowering action, may contribute to the antiatherogenic property in the early-stage atherosclerosis.</p>}},
author = {{Asai, Akira and Shuto, Yuki and Nagao, Mototsugu and Kawahara, Momoyo and Miyazawa, Teruo and Sugihara, Hitoshi and Oikawa, Shinichi}},
issn = {{1880-3873}},
language = {{eng}},
month = {{12}},
number = {{12}},
pages = {{1075--1083}},
publisher = {{Japan Atherosclerosis Society}},
series = {{Journal of Atherosclerosis and Thrombosis}},
title = {{Metformin Attenuates Early-Stage Atherosclerosis in Mildly Hyperglycemic Oikawa-Nagao Mice}},
url = {{http://dx.doi.org/10.5551/jat.48223}},
doi = {{10.5551/jat.48223}},
volume = {{26}},
year = {{2019}},
}