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Menstrual and reproductive factors in women, genetic variation in CYP17A1, and pancreatic cancer risk in the European prospective investigation into cancer and nutrition (EPIC) cohort

Duell, Eric J.; Travier, Noemie; Lujan-Barroso, Leila; Dossus, Laure; Boutron-Ruault, Marie-Christine; Clavel-Chapelon, Francoise; Tumino, Rosario; Masala, Giovanna; Krogh, Vittorio and Panico, Salvatore, et al. (2013) In International Journal of Cancer 132(9). p.2164-2175
Abstract
Menstrual and reproductive factors and exogenous hormone use have been investigated as pancreatic cancer risk factors in case-control and cohort studies, but results have been inconsistent. We conducted a prospective examination of menstrual and reproductive factors, exogenous hormone use and pancreatic cancer risk (based on 304 cases) in 328,610 women from the EPIC cohort. Then, in a case-control study nested within the EPIC cohort, we examined 12 single nucleotide polymorphisms (SNPs) in CYP17A1 (an essential gene in sex steroid metabolism) for association with pancreatic cancer in women and men (324 cases and 353 controls). Of all factors analyzed, only younger age at menarche (<12 vs. 13 years) was moderately associated with an... (More)
Menstrual and reproductive factors and exogenous hormone use have been investigated as pancreatic cancer risk factors in case-control and cohort studies, but results have been inconsistent. We conducted a prospective examination of menstrual and reproductive factors, exogenous hormone use and pancreatic cancer risk (based on 304 cases) in 328,610 women from the EPIC cohort. Then, in a case-control study nested within the EPIC cohort, we examined 12 single nucleotide polymorphisms (SNPs) in CYP17A1 (an essential gene in sex steroid metabolism) for association with pancreatic cancer in women and men (324 cases and 353 controls). Of all factors analyzed, only younger age at menarche (<12 vs. 13 years) was moderately associated with an increased risk of pancreatic cancer in the full cohort; however, this result was marginally significant (HR = 1.44; 95% CI = 0.992.10). CYP17A1 rs619824 was associated with HRT use (p value = 0.037) in control women; however, none of the SNPs alone, in combination, or as haplotypes were associated with pancreatic cancer risk. In conclusion, with the possible exception of an early age of menarche, none of the menstrual and reproductive factors, and none of the 12 common genetic variants we evaluated at the CYP17A1 locus makes a substantial contribution to pancreatic cancer susceptibility in the EPIC cohort. (Less)
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subject
keywords
CYP17A1, women, estrogens, hormones, reproduction, menstruation, pancreatic cancer
in
International Journal of Cancer
volume
132
issue
9
pages
2164 - 2175
publisher
John Wiley & Sons
external identifiers
  • wos:000315121100021
  • scopus:84874057343
ISSN
0020-7136
DOI
10.1002/ijc.27875
language
English
LU publication?
yes
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e0eaf491-1803-4722-b151-e361f03f1cd8 (old id 3576857)
date added to LUP
2013-03-25 12:00:35
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2019-03-20 09:28:21
@article{e0eaf491-1803-4722-b151-e361f03f1cd8,
  abstract     = {Menstrual and reproductive factors and exogenous hormone use have been investigated as pancreatic cancer risk factors in case-control and cohort studies, but results have been inconsistent. We conducted a prospective examination of menstrual and reproductive factors, exogenous hormone use and pancreatic cancer risk (based on 304 cases) in 328,610 women from the EPIC cohort. Then, in a case-control study nested within the EPIC cohort, we examined 12 single nucleotide polymorphisms (SNPs) in CYP17A1 (an essential gene in sex steroid metabolism) for association with pancreatic cancer in women and men (324 cases and 353 controls). Of all factors analyzed, only younger age at menarche (&lt;12 vs. 13 years) was moderately associated with an increased risk of pancreatic cancer in the full cohort; however, this result was marginally significant (HR = 1.44; 95% CI = 0.992.10). CYP17A1 rs619824 was associated with HRT use (p value = 0.037) in control women; however, none of the SNPs alone, in combination, or as haplotypes were associated with pancreatic cancer risk. In conclusion, with the possible exception of an early age of menarche, none of the menstrual and reproductive factors, and none of the 12 common genetic variants we evaluated at the CYP17A1 locus makes a substantial contribution to pancreatic cancer susceptibility in the EPIC cohort.},
  author       = {Duell, Eric J. and Travier, Noemie and Lujan-Barroso, Leila and Dossus, Laure and Boutron-Ruault, Marie-Christine and Clavel-Chapelon, Francoise and Tumino, Rosario and Masala, Giovanna and Krogh, Vittorio and Panico, Salvatore and Ricceri, Fulvio and Luisa Redondo, Maria and Dorronsoro, Miren and Molina-Montes, Esther and Huerta, Jose M. and Barricarte, Aurelio and Khaw, Kay-Tee and Wareham, Nick J. and Allen, Naomi E. and Travis, Ruth and Siersema, Peter D. and Peeters, Petra H. M. and Trichopoulou, Antonia and Fragogeorgi, Eirini and Oikonomou, Eleni and Boeing, Heiner and Schuetze, Madlen and Canzian, Federico and Lukanova, Annekatrin and Tjonneland, Anne and Roswall, Nina and Overvad, Kim and Weiderpass, Elisabete and Gram, Inger Torhild and Lund, Eiliv and Lindkvist, Bjorn and Johansen, Dorthe and Ye, Weimin and Sund, Malin and Fedirko, Veronika and Jenab, Mazda and Michaud, Dominique S. and Riboli, Elio and Bueno-de-Mesquita, H. Bas},
  issn         = {0020-7136},
  keyword      = {CYP17A1,women,estrogens,hormones,reproduction,menstruation,pancreatic cancer},
  language     = {eng},
  number       = {9},
  pages        = {2164--2175},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Menstrual and reproductive factors in women, genetic variation in CYP17A1, and pancreatic cancer risk in the European prospective investigation into cancer and nutrition (EPIC) cohort},
  url          = {http://dx.doi.org/10.1002/ijc.27875},
  volume       = {132},
  year         = {2013},
}