Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Novel Coronavirus Infection (COVID-19) in Humans : A Scoping Review and Meta-Analysis

Júnior Borges do Nascimento, Israel ; Cacic, Nensi ; Mohamed Abdulazeem, Hebatullah ; von Groote, Thilo Caspar ; Jayarajah, Umesh ; Weerasekara, Ishanka ; Abdar Esfahani, Meisam ; Tassoni Civile, Vinicius ; Marusic, Ana and Jeroncic, Ana , et al. (2020) In Journal of Clinical Medicine 9(4).
Abstract
A growing body of literature on the 2019 novel coronavirus (SARS-CoV-2) is becoming available, but a synthesis of available data has not been conducted. We performed a scoping review of currently available clinical, epidemiological, laboratory, and chest imaging data related to the SARS-CoV-2 infection. We searched MEDLINE, Cochrane CENTRAL, EMBASE, Scopus and LILACS from 01 January 2019 to 24 February 2020. Study selection, data extraction and risk of bias assessment were performed by two independent reviewers. Qualitative synthesis and meta-analysis were conducted using the clinical and laboratory data, and random-effects models were applied to estimate pooled results. A total of 61 studies were included (59,254 patients). The most... (More)
A growing body of literature on the 2019 novel coronavirus (SARS-CoV-2) is becoming available, but a synthesis of available data has not been conducted. We performed a scoping review of currently available clinical, epidemiological, laboratory, and chest imaging data related to the SARS-CoV-2 infection. We searched MEDLINE, Cochrane CENTRAL, EMBASE, Scopus and LILACS from 01 January 2019 to 24 February 2020. Study selection, data extraction and risk of bias assessment were performed by two independent reviewers. Qualitative synthesis and meta-analysis were conducted using the clinical and laboratory data, and random-effects models were applied to estimate pooled results. A total of 61 studies were included (59,254 patients). The most common disease-related symptoms were fever (82%, 95% confidence interval (CI) 56%–99%; n = 4410), cough (61%, 95% CI 39%–81%; n = 3985), muscle aches and/or fatigue (36%, 95% CI 18%–55%; n = 3778), dyspnea (26%, 95% CI 12%–41%; n = 3700), headache in 12% (95% CI 4%–23%, n = 3598 patients), sore throat in 10% (95% CI 5%–17%, n = 1387) and gastrointestinal symptoms in 9% (95% CI 3%–17%, n = 1744). Laboratory findings were described in a lower number of patients and revealed lymphopenia (0.93 × 109/L, 95% CI 0.83–1.03 × 109/L, n = 464) and abnormal C-reactive protein (33.72 mg/dL, 95% CI 21.54–45.91 mg/dL; n = 1637). Radiological findings varied, but mostly described ground-glass opacities and consolidation. Data on treatment options were limited. All-cause mortality was 0.3% (95% CI 0.0%–1.0%; n = 53,631). Epidemiological studies showed that mortality was higher in males and elderly patients. The majority of reported clinical symptoms and laboratory findings related to SARS-CoV-2 infection are non-specific. Clinical suspicion, accompanied by a relevant epidemiological history, should be followed by early imaging and virological assay. (Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and , et al. (More)
; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; and (Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Clinical Medicine
volume
9
issue
4
article number
941
publisher
MDPI AG
external identifiers
  • pmid:32235486
  • scopus:85114275868
ISSN
2077-0383
DOI
10.3390/jcm9040941
language
English
LU publication?
yes
id
e128ce2b-7980-493a-89d6-36c73f9f8dc0
date added to LUP
2020-04-07 11:12:36
date last changed
2022-05-12 01:33:17
@article{e128ce2b-7980-493a-89d6-36c73f9f8dc0,
  abstract     = {{A growing body of literature on the 2019 novel coronavirus (SARS-CoV-2) is becoming available, but a synthesis of available data has not been conducted. We performed a scoping review of currently available clinical, epidemiological, laboratory, and chest imaging data related to the SARS-CoV-2 infection. We searched MEDLINE, Cochrane CENTRAL, EMBASE, Scopus and LILACS from 01 January 2019 to 24 February 2020. Study selection, data extraction and risk of bias assessment were performed by two independent reviewers. Qualitative synthesis and meta-analysis were conducted using the clinical and laboratory data, and random-effects models were applied to estimate pooled results. A total of 61 studies were included (59,254 patients). The most common disease-related symptoms were fever (82%, 95% confidence interval (CI) 56%–99%; n = 4410), cough (61%, 95% CI 39%–81%; n = 3985), muscle aches and/or fatigue (36%, 95% CI 18%–55%; n = 3778), dyspnea (26%, 95% CI 12%–41%; n = 3700), headache in 12% (95% CI 4%–23%, n = 3598 patients), sore throat in 10% (95% CI 5%–17%, n = 1387) and gastrointestinal symptoms in 9% (95% CI 3%–17%, n = 1744). Laboratory findings were described in a lower number of patients and revealed lymphopenia (0.93 × 109/L, 95% CI 0.83–1.03 × 109/L, n = 464) and abnormal C-reactive protein (33.72 mg/dL, 95% CI 21.54–45.91 mg/dL; n = 1637). Radiological findings varied, but mostly described ground-glass opacities and consolidation. Data on treatment options were limited. All-cause mortality was 0.3% (95% CI 0.0%–1.0%; n = 53,631). Epidemiological studies showed that mortality was higher in males and elderly patients. The majority of reported clinical symptoms and laboratory findings related to SARS-CoV-2 infection are non-specific. Clinical suspicion, accompanied by a relevant epidemiological history, should be followed by early imaging and virological assay.}},
  author       = {{Júnior Borges do Nascimento, Israel and Cacic, Nensi and Mohamed Abdulazeem, Hebatullah and von Groote, Thilo Caspar and Jayarajah, Umesh and Weerasekara, Ishanka and Abdar Esfahani, Meisam and Tassoni Civile, Vinicius and Marusic, Ana and Jeroncic, Ana and Carvas Junior, Nelson and Poklepovic Pericic, Tina and Zakarija-Grkovic, Irena and Mangeon Meirelles Guimarães, Silvana and Luigi Bragazzi, Nicola and Björklund, Maria and Sofi-Mahmudi, Ahmad and Altujjar, Mohammad and Tian, Maoyi and Cespedes Arcani, Diana Maria and O’Mathúna, Dónal P. and Soriano Marcolino, Milena}},
  issn         = {{2077-0383}},
  language     = {{eng}},
  month        = {{03}},
  number       = {{4}},
  publisher    = {{MDPI AG}},
  series       = {{Journal of Clinical Medicine}},
  title        = {{Novel Coronavirus Infection (COVID-19) in Humans : A Scoping Review and Meta-Analysis}},
  url          = {{http://dx.doi.org/10.3390/jcm9040941}},
  doi          = {{10.3390/jcm9040941}},
  volume       = {{9}},
  year         = {{2020}},
}