Hepatitis B virus-DNA in the serum of patients followed-up longitudinally with acute and chronic hepatitis B
(1985) In Journal of Medical Virology 17(4). p.337-344- Abstract
- Sera from 79 patients with acute self-limiting hepatitis, 17 patients with acute hepatitis B evolving into chronic HBsAg carriership, and 43 chronic HBsAg carriers without a history of acute hepatitis were analyzed for presence of hepatitis B virus (HBV)-DNA by a molecular hybridization technique. In acute self-limiting hepatitis, HBV-DNA was cleared within a few weeks after the onset of clinical symptoms. The longest period of DNA positivity observed in this group was 42 days. In 29 of 52 patients HBV-DNA was cleared before HBeAg disappeared. Among 17 patients who became chronic HBsAg carriers, HBV-DNA was present for more than 6 months in all but one. Most of the HBsAg carriers eventually cleared HBV-DNA. The DNA clearance frequently... (More)
- Sera from 79 patients with acute self-limiting hepatitis, 17 patients with acute hepatitis B evolving into chronic HBsAg carriership, and 43 chronic HBsAg carriers without a history of acute hepatitis were analyzed for presence of hepatitis B virus (HBV)-DNA by a molecular hybridization technique. In acute self-limiting hepatitis, HBV-DNA was cleared within a few weeks after the onset of clinical symptoms. The longest period of DNA positivity observed in this group was 42 days. In 29 of 52 patients HBV-DNA was cleared before HBeAg disappeared. Among 17 patients who became chronic HBsAg carriers, HBV-DNA was present for more than 6 months in all but one. Most of the HBsAg carriers eventually cleared HBV-DNA. The DNA clearance frequently preceeded the conversion of HBeAg to anti-HBe. Thus, in many patients there was a transitional period with HBeAg but without HBV-DNA. HBV-DNA was found to be a better index of impending chronicity than HBeAg since persistence of HBeAg for more than 42 days was noted in 10% of the patients who nevertheless cleared HBsAg within 6 months. By that time all those patients had turned negative for HBV-DNA. On the other hand, in 16 of the 17 patients who became chronic carriers of HBsAg, HBV-DNA as well as HBeAg persisted for more than 6 months. The present results also suggest that infectivity in acute hepatitis B is a feature mainly of the presymptomatic and early symptomatic period. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1103352
- author
- Moestrup, T ; Hansson, B G ; Widell, Anders LU ; Blomberg, J and Nordenfelt, E
- organization
- publishing date
- 1985
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- hepatitis, viral DNA, molecular hybridization, HBeAg
- in
- Journal of Medical Virology
- volume
- 17
- issue
- 4
- pages
- 337 - 344
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:4078560
- scopus:0022340983
- ISSN
- 1096-9071
- DOI
- 10.1002/jmv.1890170406
- language
- English
- LU publication?
- yes
- id
- e135c7dd-8271-4c8d-b49d-0fb29a85a078 (old id 1103352)
- date added to LUP
- 2016-04-01 12:21:37
- date last changed
- 2021-01-03 05:57:40
@article{e135c7dd-8271-4c8d-b49d-0fb29a85a078,
abstract = {{Sera from 79 patients with acute self-limiting hepatitis, 17 patients with acute hepatitis B evolving into chronic HBsAg carriership, and 43 chronic HBsAg carriers without a history of acute hepatitis were analyzed for presence of hepatitis B virus (HBV)-DNA by a molecular hybridization technique. In acute self-limiting hepatitis, HBV-DNA was cleared within a few weeks after the onset of clinical symptoms. The longest period of DNA positivity observed in this group was 42 days. In 29 of 52 patients HBV-DNA was cleared before HBeAg disappeared. Among 17 patients who became chronic HBsAg carriers, HBV-DNA was present for more than 6 months in all but one. Most of the HBsAg carriers eventually cleared HBV-DNA. The DNA clearance frequently preceeded the conversion of HBeAg to anti-HBe. Thus, in many patients there was a transitional period with HBeAg but without HBV-DNA. HBV-DNA was found to be a better index of impending chronicity than HBeAg since persistence of HBeAg for more than 42 days was noted in 10% of the patients who nevertheless cleared HBsAg within 6 months. By that time all those patients had turned negative for HBV-DNA. On the other hand, in 16 of the 17 patients who became chronic carriers of HBsAg, HBV-DNA as well as HBeAg persisted for more than 6 months. The present results also suggest that infectivity in acute hepatitis B is a feature mainly of the presymptomatic and early symptomatic period.}},
author = {{Moestrup, T and Hansson, B G and Widell, Anders and Blomberg, J and Nordenfelt, E}},
issn = {{1096-9071}},
keywords = {{hepatitis; viral DNA; molecular hybridization; HBeAg}},
language = {{eng}},
number = {{4}},
pages = {{337--344}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Journal of Medical Virology}},
title = {{Hepatitis B virus-DNA in the serum of patients followed-up longitudinally with acute and chronic hepatitis B}},
url = {{http://dx.doi.org/10.1002/jmv.1890170406}},
doi = {{10.1002/jmv.1890170406}},
volume = {{17}},
year = {{1985}},
}