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A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.

Speedy, Helen E ; Di Bernardo, Maria Chiara ; Sava, Georgina P ; Dyer, Martin J S ; Holroyd, Amy ; Wang, Yufei ; Sunter, Nicola J ; Mansouri, Larry ; Juliusson, Gunnar LU and Smedby, Karin E , et al. (2014) In Nature Genetics 46(1). p.56-56
Abstract
Genome-wide association studies (GWAS) of chronic lymphocytic leukemia (CLL) have shown that common genetic variation contributes to the heritable risk of CLL. To identify additional CLL susceptibility loci, we conducted a GWAS and performed a meta-analysis with a published GWAS totaling 1,739 individuals with CLL (cases) and 5,199 controls with validation in an additional 1,144 cases and 3,151 controls. A combined analysis identified new susceptibility loci mapping to 3q26.2 (rs10936599, P = 1.74 × 10(-9)), 4q26 (rs6858698, P = 3.07 × 10(-9)), 6q25.2 (IPCEF1, rs2236256, P = 1.50 × 10(-10)) and 7q31.33 (POT1, rs17246404, P = 3.40 × 10(-8)). Additionally, we identified a promising association at 5p15.33 (CLPTM1L, rs31490, P = 1.72 × 10(-7))... (More)
Genome-wide association studies (GWAS) of chronic lymphocytic leukemia (CLL) have shown that common genetic variation contributes to the heritable risk of CLL. To identify additional CLL susceptibility loci, we conducted a GWAS and performed a meta-analysis with a published GWAS totaling 1,739 individuals with CLL (cases) and 5,199 controls with validation in an additional 1,144 cases and 3,151 controls. A combined analysis identified new susceptibility loci mapping to 3q26.2 (rs10936599, P = 1.74 × 10(-9)), 4q26 (rs6858698, P = 3.07 × 10(-9)), 6q25.2 (IPCEF1, rs2236256, P = 1.50 × 10(-10)) and 7q31.33 (POT1, rs17246404, P = 3.40 × 10(-8)). Additionally, we identified a promising association at 5p15.33 (CLPTM1L, rs31490, P = 1.72 × 10(-7)) and validated recently reported putative associations at 5p15.33 (TERT, rs10069690, P = 1.12 × 10(-10)) and 8q22.3 (rs2511714, P = 2.90 × 10(-9)). These findings provide further insights into the genetic and biological basis of inherited genetic susceptibility to CLL. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nature Genetics
volume
46
issue
1
pages
56 - 56
publisher
Nature Publishing Group
external identifiers
  • wos:000329113500013
  • pmid:24292274
  • scopus:84891371778
  • pmid:24292274
ISSN
1546-1718
DOI
10.1038/ng.2843
language
English
LU publication?
yes
id
e1369ee9-f63b-414e-93f2-d300a26a87ea (old id 4225448)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24292274?dopt=Abstract
date added to LUP
2016-04-01 10:14:43
date last changed
2022-07-21 07:46:48
@article{e1369ee9-f63b-414e-93f2-d300a26a87ea,
  abstract     = {{Genome-wide association studies (GWAS) of chronic lymphocytic leukemia (CLL) have shown that common genetic variation contributes to the heritable risk of CLL. To identify additional CLL susceptibility loci, we conducted a GWAS and performed a meta-analysis with a published GWAS totaling 1,739 individuals with CLL (cases) and 5,199 controls with validation in an additional 1,144 cases and 3,151 controls. A combined analysis identified new susceptibility loci mapping to 3q26.2 (rs10936599, P = 1.74 × 10(-9)), 4q26 (rs6858698, P = 3.07 × 10(-9)), 6q25.2 (IPCEF1, rs2236256, P = 1.50 × 10(-10)) and 7q31.33 (POT1, rs17246404, P = 3.40 × 10(-8)). Additionally, we identified a promising association at 5p15.33 (CLPTM1L, rs31490, P = 1.72 × 10(-7)) and validated recently reported putative associations at 5p15.33 (TERT, rs10069690, P = 1.12 × 10(-10)) and 8q22.3 (rs2511714, P = 2.90 × 10(-9)). These findings provide further insights into the genetic and biological basis of inherited genetic susceptibility to CLL.}},
  author       = {{Speedy, Helen E and Di Bernardo, Maria Chiara and Sava, Georgina P and Dyer, Martin J S and Holroyd, Amy and Wang, Yufei and Sunter, Nicola J and Mansouri, Larry and Juliusson, Gunnar and Smedby, Karin E and Roos, Göran and Jayne, Sandrine and Majid, Aneela and Dearden, Claire and Hall, Andrew G and Mainou-Fowler, Tryfonia and Jackson, Graham H and Summerfield, Geoffrey and Harris, Robert J and Pettitt, Andrew R and Allsup, David J and Bailey, James R and Pratt, Guy and Pepper, Chris and Fegan, Chris and Rosenquist, Richard and Catovsky, Daniel and Allan, James M and Houlston, Richard S}},
  issn         = {{1546-1718}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{56--56}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Nature Genetics}},
  title        = {{A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.}},
  url          = {{http://dx.doi.org/10.1038/ng.2843}},
  doi          = {{10.1038/ng.2843}},
  volume       = {{46}},
  year         = {{2014}},
}