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Pleuropulmonary pathologies in the early phase of acute pancreatitis correlate with disease severity

Luiken, Ina ; Eisenmann, Stephan ; Garbe, Jakob ; Sternby, Hanna LU ; Verdonk, Robert C. ; Dimova, Alexandra ; Ignatavicius, Povilas ; Ilzarbe, Lucas ; Koiva, Peeter and Penttilä, Anne K. , et al. (2022) In PLoS ONE 17(2 February).
Abstract

Background Respiratory failure worsens the outcome of acute pancreatitis (AP) and underlying factors might be early detectable. Aims To evaluate the prevalence and prognostic relevance of early pleuropulmonary pathologies and pre-existing chronic lung diseases (CLD) in AP patients. Methods Multicentre retrospective cohort study. Caudal sections of the thorax derived from abdominal contrast enhanced computed tomography (CECT) performed in the early phase of AP were assessed. Independent predictors of severe AP were identified by binary logistic regression analysis. A one-year survival analysis using Kaplan-Meier curves and log rank test was performed. Results 358 patients were analysed, finding pleuropulmonary pathologies in 81%. CECTs... (More)

Background Respiratory failure worsens the outcome of acute pancreatitis (AP) and underlying factors might be early detectable. Aims To evaluate the prevalence and prognostic relevance of early pleuropulmonary pathologies and pre-existing chronic lung diseases (CLD) in AP patients. Methods Multicentre retrospective cohort study. Caudal sections of the thorax derived from abdominal contrast enhanced computed tomography (CECT) performed in the early phase of AP were assessed. Independent predictors of severe AP were identified by binary logistic regression analysis. A one-year survival analysis using Kaplan-Meier curves and log rank test was performed. Results 358 patients were analysed, finding pleuropulmonary pathologies in 81%. CECTs were performed with a median of 2 days (IQR 1–3) after admission. Multivariable analysis identified moderate to severe or bilateral pleural effusions (PEs) (OR = 4.16, 95%CI 2.05–8.45, p<0.001) and pre-existing CLD (OR = 2.93, 95%CI 1.17–7.32, p = 0.022) as independent predictors of severe AP. Log rank test showed a significantly worse one-year survival in patients with bilateral compared to unilateral PEs in a subgroup. Conclusions Increasing awareness of the prognostic impact of large and bilateral PEs and pre-existing CLD could facilitate the identification of patients at high risk for severe AP in the early phase and thus improve their prognosis.

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organization
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type
Contribution to journal
publication status
published
subject
in
PLoS ONE
volume
17
issue
2 February
article number
e0263739
publisher
Public Library of Science (PLoS)
external identifiers
  • pmid:35130290
  • scopus:85124220374
ISSN
1932-6203
DOI
10.1371/journal.pone.0263739
language
English
LU publication?
yes
id
e1886ba5-d035-45ed-a80a-3371cf237c11
date added to LUP
2023-01-19 13:57:03
date last changed
2025-03-08 01:38:42
@article{e1886ba5-d035-45ed-a80a-3371cf237c11,
  abstract     = {{<p>Background Respiratory failure worsens the outcome of acute pancreatitis (AP) and underlying factors might be early detectable. Aims To evaluate the prevalence and prognostic relevance of early pleuropulmonary pathologies and pre-existing chronic lung diseases (CLD) in AP patients. Methods Multicentre retrospective cohort study. Caudal sections of the thorax derived from abdominal contrast enhanced computed tomography (CECT) performed in the early phase of AP were assessed. Independent predictors of severe AP were identified by binary logistic regression analysis. A one-year survival analysis using Kaplan-Meier curves and log rank test was performed. Results 358 patients were analysed, finding pleuropulmonary pathologies in 81%. CECTs were performed with a median of 2 days (IQR 1–3) after admission. Multivariable analysis identified moderate to severe or bilateral pleural effusions (PEs) (OR = 4.16, 95%CI 2.05–8.45, p&lt;0.001) and pre-existing CLD (OR = 2.93, 95%CI 1.17–7.32, p = 0.022) as independent predictors of severe AP. Log rank test showed a significantly worse one-year survival in patients with bilateral compared to unilateral PEs in a subgroup. Conclusions Increasing awareness of the prognostic impact of large and bilateral PEs and pre-existing CLD could facilitate the identification of patients at high risk for severe AP in the early phase and thus improve their prognosis.</p>}},
  author       = {{Luiken, Ina and Eisenmann, Stephan and Garbe, Jakob and Sternby, Hanna and Verdonk, Robert C. and Dimova, Alexandra and Ignatavicius, Povilas and Ilzarbe, Lucas and Koiva, Peeter and Penttilä, Anne K. and Regnér, Sara and Dober, Johannes and Wohlgemuth, Walter A. and Brill, Richard and Michl, Patrick and Rosendahl, Jonas and Damm, Marko}},
  issn         = {{1932-6203}},
  language     = {{eng}},
  number       = {{2 February}},
  publisher    = {{Public Library of Science (PLoS)}},
  series       = {{PLoS ONE}},
  title        = {{Pleuropulmonary pathologies in the early phase of acute pancreatitis correlate with disease severity}},
  url          = {{http://dx.doi.org/10.1371/journal.pone.0263739}},
  doi          = {{10.1371/journal.pone.0263739}},
  volume       = {{17}},
  year         = {{2022}},
}