Impact of trigeminal nerve and/or olfactory nerve stimulation on activity of human brain regions involved in the perception of breathlessness
(2023) In Respiratory Physiology and Neurobiology 311.- Abstract
Breathlessness is a centrally processed symptom, as evidenced by activation of distinct brain regions such as the insular cortex and amygdala, during the anticipation and/or perception of breathlessness. Inhaled L-menthol or blowing cool air to the face/nose, both selective trigeminal nerve (TGN) stimulants, relieve breathlessness without concurrent improvements in physiological outcomes (e.g., breathing pattern), suggesting a possible but hitherto unexplored central mechanism of action. Four databases were searched to identify published reports supporting a link between TGN stimulation and activation of brain regions involved in the anticipation and/or perception of breathlessness. The collective results of the 29 studies demonstrated... (More)
Breathlessness is a centrally processed symptom, as evidenced by activation of distinct brain regions such as the insular cortex and amygdala, during the anticipation and/or perception of breathlessness. Inhaled L-menthol or blowing cool air to the face/nose, both selective trigeminal nerve (TGN) stimulants, relieve breathlessness without concurrent improvements in physiological outcomes (e.g., breathing pattern), suggesting a possible but hitherto unexplored central mechanism of action. Four databases were searched to identify published reports supporting a link between TGN stimulation and activation of brain regions involved in the anticipation and/or perception of breathlessness. The collective results of the 29 studies demonstrated that TGN stimulation activated 12 brain regions widely implicated in the anticipation and/or perception of breathlessness, including the insular cortex and amygdala. Inhaled L-menthol or cool air to the face activated 75% and 33% of these 12 brain regions, respectively. Our findings support the hypothesis that TGN stimulation contributes to breathlessness relief by altering the activity of brain regions involved in its central neural processing.
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- author
- Aucoin, Rachelle ; Lewthwaite, Hayley ; Ekström, Magnus LU ; von Leupoldt, Andreas and Jensen, Dennis
- organization
- publishing date
- 2023-05
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Breathlessnes, Cool air, Eural activity, L-Menthol, Olfactory nerve, Trigeminal nerve
- in
- Respiratory Physiology and Neurobiology
- volume
- 311
- article number
- 104036
- publisher
- Elsevier
- external identifiers
-
- pmid:36804472
- scopus:85148636748
- ISSN
- 1569-9048
- DOI
- 10.1016/j.resp.2023.104036
- language
- English
- LU publication?
- yes
- id
- e18950cc-4ee2-4d1a-99fa-17b262e57208
- date added to LUP
- 2023-04-13 11:19:22
- date last changed
- 2024-10-05 13:49:57
@article{e18950cc-4ee2-4d1a-99fa-17b262e57208, abstract = {{<p>Breathlessness is a centrally processed symptom, as evidenced by activation of distinct brain regions such as the insular cortex and amygdala, during the anticipation and/or perception of breathlessness. Inhaled L-menthol or blowing cool air to the face/nose, both selective trigeminal nerve (TGN) stimulants, relieve breathlessness without concurrent improvements in physiological outcomes (e.g., breathing pattern), suggesting a possible but hitherto unexplored central mechanism of action. Four databases were searched to identify published reports supporting a link between TGN stimulation and activation of brain regions involved in the anticipation and/or perception of breathlessness. The collective results of the 29 studies demonstrated that TGN stimulation activated 12 brain regions widely implicated in the anticipation and/or perception of breathlessness, including the insular cortex and amygdala. Inhaled L-menthol or cool air to the face activated 75% and 33% of these 12 brain regions, respectively. Our findings support the hypothesis that TGN stimulation contributes to breathlessness relief by altering the activity of brain regions involved in its central neural processing.</p>}}, author = {{Aucoin, Rachelle and Lewthwaite, Hayley and Ekström, Magnus and von Leupoldt, Andreas and Jensen, Dennis}}, issn = {{1569-9048}}, keywords = {{Breathlessnes; Cool air; Eural activity; L-Menthol; Olfactory nerve; Trigeminal nerve}}, language = {{eng}}, publisher = {{Elsevier}}, series = {{Respiratory Physiology and Neurobiology}}, title = {{Impact of trigeminal nerve and/or olfactory nerve stimulation on activity of human brain regions involved in the perception of breathlessness}}, url = {{http://dx.doi.org/10.1016/j.resp.2023.104036}}, doi = {{10.1016/j.resp.2023.104036}}, volume = {{311}}, year = {{2023}}, }