Impact of trigeminal nerve and/or olfactory nerve stimulation on activity of human brain regions involved in the perception of breathlessness
Aucoin, Rachelle ; Lewthwaite, Hayley ; Ekström, Magnus LU
; von Leupoldt, Andreas
and Jensen, Dennis
(2023)
In Respiratory Physiology and Neurobiology
311.
- Abstract
Breathlessness is a centrally processed symptom, as evidenced by activation of distinct brain regions such as the insular cortex and amygdala, during the anticipation and/or perception of breathlessness. Inhaled L-menthol or blowing cool air to the face/nose, both selective trigeminal nerve (TGN) stimulants, relieve breathlessness without concurrent improvements in physiological outcomes (e.g., breathing pattern), suggesting a possible but hitherto unexplored central mechanism of action. Four databases were searched to identify published reports supporting a link between TGN stimulation and activation of brain regions involved in the anticipation and/or perception of breathlessness. The collective results of the 29 studies demonstrated... (More)
Breathlessness is a centrally processed symptom, as evidenced by activation of distinct brain regions such as the insular cortex and amygdala, during the anticipation and/or perception of breathlessness. Inhaled L-menthol or blowing cool air to the face/nose, both selective trigeminal nerve (TGN) stimulants, relieve breathlessness without concurrent improvements in physiological outcomes (e.g., breathing pattern), suggesting a possible but hitherto unexplored central mechanism of action. Four databases were searched to identify published reports supporting a link between TGN stimulation and activation of brain regions involved in the anticipation and/or perception of breathlessness. The collective results of the 29 studies demonstrated that TGN stimulation activated 12 brain regions widely implicated in the anticipation and/or perception of breathlessness, including the insular cortex and amygdala. Inhaled L-menthol or cool air to the face activated 75% and 33% of these 12 brain regions, respectively. Our findings support the hypothesis that TGN stimulation contributes to breathlessness relief by altering the activity of brain regions involved in its central neural processing.
(Less)
- author
- Aucoin, Rachelle
; Lewthwaite, Hayley
; Ekström, Magnus
LU
; von Leupoldt, Andreas
and Jensen, Dennis
- organization
- publishing date
- 2023-05
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Breathlessnes, Cool air, Eural activity, L-Menthol, Olfactory nerve, Trigeminal nerve
- in
- Respiratory Physiology and Neurobiology
- volume
- 311
- article number
- 104036
- publisher
- Elsevier
- external identifiers
-
- scopus:85148636748
- pmid:36804472
- ISSN
- 1569-9048
- DOI
- 10.1016/j.resp.2023.104036
- language
- English
- LU publication?
- yes
- id
- e18950cc-4ee2-4d1a-99fa-17b262e57208
- date added to LUP
- 2023-04-13 11:19:22
- date last changed
- 2024-06-15 01:52:33
@article{e18950cc-4ee2-4d1a-99fa-17b262e57208,
abstract = {{<p>Breathlessness is a centrally processed symptom, as evidenced by activation of distinct brain regions such as the insular cortex and amygdala, during the anticipation and/or perception of breathlessness. Inhaled L-menthol or blowing cool air to the face/nose, both selective trigeminal nerve (TGN) stimulants, relieve breathlessness without concurrent improvements in physiological outcomes (e.g., breathing pattern), suggesting a possible but hitherto unexplored central mechanism of action. Four databases were searched to identify published reports supporting a link between TGN stimulation and activation of brain regions involved in the anticipation and/or perception of breathlessness. The collective results of the 29 studies demonstrated that TGN stimulation activated 12 brain regions widely implicated in the anticipation and/or perception of breathlessness, including the insular cortex and amygdala. Inhaled L-menthol or cool air to the face activated 75% and 33% of these 12 brain regions, respectively. Our findings support the hypothesis that TGN stimulation contributes to breathlessness relief by altering the activity of brain regions involved in its central neural processing.</p>}},
author = {{Aucoin, Rachelle and Lewthwaite, Hayley and Ekström, Magnus and von Leupoldt, Andreas and Jensen, Dennis}},
issn = {{1569-9048}},
keywords = {{Breathlessnes; Cool air; Eural activity; L-Menthol; Olfactory nerve; Trigeminal nerve}},
language = {{eng}},
publisher = {{Elsevier}},
series = {{Respiratory Physiology and Neurobiology}},
title = {{Impact of trigeminal nerve and/or olfactory nerve stimulation on activity of human brain regions involved in the perception of breathlessness}},
url = {{http://dx.doi.org/10.1016/j.resp.2023.104036}},
doi = {{10.1016/j.resp.2023.104036}},
volume = {{311}},
year = {{2023}},
}