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Delayed Gadolinium-Enhanced MRI of Menisci and Cartilage (dGEMRIM/dGEMRIC) in Obese Patients With Knee Osteoarthritis : Cross-Sectional Study of 85 Obese Patients With Intra-articular Administered Gadolinium Contrast

Hangaard, Stine ; Gudbergsen, Henrik ; Daugaard, Cecilie L. ; Bliddal, Henning ; Nybing, Janus Damm ; Nieminen, Miika T. ; Casula, Victor ; Tiderius, Carl Johan LU and Boesen, Mikael (2018) In Journal of Magnetic Resonance Imaging 48(6). p.1700-1706
Abstract

Background: Early cartilage changes in knee osteoarthritis (OA) can be assessed by both intravenous (i.v.) and intra-articular (i.a.) delayed gadolinium-enhanced MRI of cartilage (dGEMRIC). Purpose: To examine the relationship between i.a. dGEMRIC and delayed gadolinium-enhanced MRI of menisci (dGEMRIM), and to investigate if the approach can be used to assess the morphological degeneration of menisci in obese patients with knee OA. Study Type: Cross-sectional. Population: Eighty-five obese patients with knee OA. Field Strength/Sequences: 1.5T. Inversion recovery sequence with four inversion times. Assessment: T1 relaxation times were calculated for posterior weight-bearing femoral cartilage and the posterior horns of the... (More)

Background: Early cartilage changes in knee osteoarthritis (OA) can be assessed by both intravenous (i.v.) and intra-articular (i.a.) delayed gadolinium-enhanced MRI of cartilage (dGEMRIC). Purpose: To examine the relationship between i.a. dGEMRIC and delayed gadolinium-enhanced MRI of menisci (dGEMRIM), and to investigate if the approach can be used to assess the morphological degeneration of menisci in obese patients with knee OA. Study Type: Cross-sectional. Population: Eighty-five obese patients with knee OA. Field Strength/Sequences: 1.5T. Inversion recovery sequence with four inversion times. Assessment: T1 relaxation times were calculated for posterior weight-bearing femoral cartilage and the posterior horns of the menisci. Meniscus degeneration sum score (0–2) was assessed as increased signal/no signal (1/0) and tear/no tear (1/0). Statistical Tests: T1 relaxation times were compared using Student's t-test. Comparison of cartilage and meniscus T1 relaxation times was done by regression analysis. Analysis of variance (ANOVA) was used for comparison of meniscal T1 relaxation times among the three summed morphological scores (0–2). Statistical analyses were performed with a level of significance at 0.05. Results: For lateral menisci, morphology sum scores of 0, 1, and 2 were found in 13, 58, and 14 patients and for medial menisci in 2, 30, and 30 patients, respectively. Mean T1 relaxation times were 441 msec, 480 msec, and 497 msec for cartilage, lateral menisci, and medial menisci, respectively. T1 relaxation times for the menisci were similar (P = 0.53), and a weak correlation was found between dGEMRIC and dGEMRIM in the lateral compartments (R = 0.26). Comparing dGEMRIM between different morphology sum scores showed no differences (P > 0.4). Data Conclusion: I.a. dGEMRIM showed no correlation between the degree of meniscal degeneration and meniscus T1 relaxation times. I.a. dGEMRIM do not seem to deliver useful information about meniscus degeneration to be suitable for clinical applications, but i.a. dGEMRIC may still be considered an alternative contrast-saving method for cartilage. Level of Evidence: 3. Technical Efficacy: Stage 3. J. Magn. Reson. Imaging 2018;00:000–000.

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organization
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type
Contribution to journal
publication status
published
subject
keywords
cartilage, contrast enhanced MRI, gadolinium, meniscus, osteoarthritis
in
Journal of Magnetic Resonance Imaging
volume
48
issue
6
pages
1700 - 1706
publisher
John Wiley & Sons Inc.
external identifiers
  • pmid:30102447
  • scopus:85052444710
ISSN
1053-1807
DOI
10.1002/jmri.26190
language
English
LU publication?
yes
id
e19d264d-0571-4847-816e-2818aa273b72
date added to LUP
2018-10-05 10:10:27
date last changed
2024-10-15 08:20:00
@article{e19d264d-0571-4847-816e-2818aa273b72,
  abstract     = {{<p>Background: Early cartilage changes in knee osteoarthritis (OA) can be assessed by both intravenous (i.v.) and intra-articular (i.a.) delayed gadolinium-enhanced MRI of cartilage (dGEMRIC). Purpose: To examine the relationship between i.a. dGEMRIC and delayed gadolinium-enhanced MRI of menisci (dGEMRIM), and to investigate if the approach can be used to assess the morphological degeneration of menisci in obese patients with knee OA. Study Type: Cross-sectional. Population: Eighty-five obese patients with knee OA. Field Strength/Sequences: 1.5T. Inversion recovery sequence with four inversion times. Assessment: T<sub>1</sub> relaxation times were calculated for posterior weight-bearing femoral cartilage and the posterior horns of the menisci. Meniscus degeneration sum score (0–2) was assessed as increased signal/no signal (1/0) and tear/no tear (1/0). Statistical Tests: T<sub>1</sub> relaxation times were compared using Student's t-test. Comparison of cartilage and meniscus T<sub>1</sub> relaxation times was done by regression analysis. Analysis of variance (ANOVA) was used for comparison of meniscal T<sub>1</sub> relaxation times among the three summed morphological scores (0–2). Statistical analyses were performed with a level of significance at 0.05. Results: For lateral menisci, morphology sum scores of 0, 1, and 2 were found in 13, 58, and 14 patients and for medial menisci in 2, 30, and 30 patients, respectively. Mean T<sub>1</sub> relaxation times were 441 msec, 480 msec, and 497 msec for cartilage, lateral menisci, and medial menisci, respectively. T<sub>1</sub> relaxation times for the menisci were similar (P = 0.53), and a weak correlation was found between dGEMRIC and dGEMRIM in the lateral compartments (R = 0.26). Comparing dGEMRIM between different morphology sum scores showed no differences (P &gt; 0.4). Data Conclusion: I.a. dGEMRIM showed no correlation between the degree of meniscal degeneration and meniscus T<sub>1</sub> relaxation times. I.a. dGEMRIM do not seem to deliver useful information about meniscus degeneration to be suitable for clinical applications, but i.a. dGEMRIC may still be considered an alternative contrast-saving method for cartilage. Level of Evidence: 3. Technical Efficacy: Stage 3. J. Magn. Reson. Imaging 2018;00:000–000.</p>}},
  author       = {{Hangaard, Stine and Gudbergsen, Henrik and Daugaard, Cecilie L. and Bliddal, Henning and Nybing, Janus Damm and Nieminen, Miika T. and Casula, Victor and Tiderius, Carl Johan and Boesen, Mikael}},
  issn         = {{1053-1807}},
  keywords     = {{cartilage; contrast enhanced MRI; gadolinium; meniscus; osteoarthritis}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{1700--1706}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Journal of Magnetic Resonance Imaging}},
  title        = {{Delayed Gadolinium-Enhanced MRI of Menisci and Cartilage (dGEMRIM/dGEMRIC) in Obese Patients With Knee Osteoarthritis : Cross-Sectional Study of 85 Obese Patients With Intra-articular Administered Gadolinium Contrast}},
  url          = {{http://dx.doi.org/10.1002/jmri.26190}},
  doi          = {{10.1002/jmri.26190}},
  volume       = {{48}},
  year         = {{2018}},
}