Evidence of tendon microtears due to cyclical loading in an in vivo tendinopathy model
(2005) In Journal of Orthopaedic Research 23(5). p.1199-1205- Abstract
- Tendon injuries at the epicondyle can occur in athletes and workers whose job functions involve repetitive, high force hand activities, but the early pathophysiologic changes of tendon are not well known. The purpose of this study was to evaluate early tendon structural changes, specifically the formation of microtears, caused by cyclical loading. The Flexor Digitorum Profundus (FDP) muscle of nine New Zealand White rabbits was stimulated to contract repetitively for 80 h of cumulative loading over 14 weeks. The contralateral limb served as a control, The tendon at the medial epicondyle insertion site was harvested, sectioned, and stained. Microtears were quantified, using image analysis software, in four regions of the tendon, two regions... (More)
- Tendon injuries at the epicondyle can occur in athletes and workers whose job functions involve repetitive, high force hand activities, but the early pathophysiologic changes of tendon are not well known. The purpose of this study was to evaluate early tendon structural changes, specifically the formation of microtears, caused by cyclical loading. The Flexor Digitorum Profundus (FDP) muscle of nine New Zealand White rabbits was stimulated to contract repetitively for 80 h of cumulative loading over 14 weeks. The contralateral limb served as a control, The tendon at the medial epicondyle insertion site was harvested, sectioned, and stained. Microtears were quantified, using image analysis software, in four regions of the tendon, two regions along the enthesis and two distal to the enthesis. The tear density (loaded: 1329 +/- 546 tears/mm(2); unloaded: 932 474 tears/mm(2)) and mean tear size (loaded: 18.3 +/- 6.1 mu m(2); unloaded: 14.0 +/- 4.8 mu m(2)) were significantly greater in the loaded limb (p < 0.0001) across all regions compared to the unloaded contralateral limb. These early microstructural changes in a repetitively loaded tendon may initiate a degenerative process that leads to tendinosis. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/891538
- author
- Nakama, L H ; King, K B ; Abrahamsson, Sven LU and Rempel, D M
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- microtears, tendinopathy, tendon, overuse, epicondylitis
- in
- Journal of Orthopaedic Research
- volume
- 23
- issue
- 5
- pages
- 1199 - 1205
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:16140201
- wos:000232173600030
- scopus:24344442851
- ISSN
- 1554-527X
- DOI
- 10.1016/j.orthres.2005.03.006
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Reconstructive Surgery (013240300)
- id
- e1a48cb7-e4d8-4a25-95ba-8a073a875891 (old id 891538)
- date added to LUP
- 2016-04-01 12:09:17
- date last changed
- 2025-04-04 14:36:24
@article{e1a48cb7-e4d8-4a25-95ba-8a073a875891,
abstract = {{Tendon injuries at the epicondyle can occur in athletes and workers whose job functions involve repetitive, high force hand activities, but the early pathophysiologic changes of tendon are not well known. The purpose of this study was to evaluate early tendon structural changes, specifically the formation of microtears, caused by cyclical loading. The Flexor Digitorum Profundus (FDP) muscle of nine New Zealand White rabbits was stimulated to contract repetitively for 80 h of cumulative loading over 14 weeks. The contralateral limb served as a control, The tendon at the medial epicondyle insertion site was harvested, sectioned, and stained. Microtears were quantified, using image analysis software, in four regions of the tendon, two regions along the enthesis and two distal to the enthesis. The tear density (loaded: 1329 +/- 546 tears/mm(2); unloaded: 932 474 tears/mm(2)) and mean tear size (loaded: 18.3 +/- 6.1 mu m(2); unloaded: 14.0 +/- 4.8 mu m(2)) were significantly greater in the loaded limb (p < 0.0001) across all regions compared to the unloaded contralateral limb. These early microstructural changes in a repetitively loaded tendon may initiate a degenerative process that leads to tendinosis.}},
author = {{Nakama, L H and King, K B and Abrahamsson, Sven and Rempel, D M}},
issn = {{1554-527X}},
keywords = {{microtears; tendinopathy; tendon; overuse; epicondylitis}},
language = {{eng}},
number = {{5}},
pages = {{1199--1205}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Journal of Orthopaedic Research}},
title = {{Evidence of tendon microtears due to cyclical loading in an in vivo tendinopathy model}},
url = {{http://dx.doi.org/10.1016/j.orthres.2005.03.006}},
doi = {{10.1016/j.orthres.2005.03.006}},
volume = {{23}},
year = {{2005}},
}