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Assessment of human sinus cavity air volume using tunable diode laser spectroscopy, with application to sinusitis diagnostics.

Huang, Jing ; Zhang, Hao ; Li, Tianqi ; Lin, Huiying ; Svanberg, Katarina LU and Svanberg, Sune LU (2015) In Journal of Biophotonics 8(11-12). p.985-992
Abstract
Sinusitis is a very common disease and improved diagnostic tools are desirable also in view of reducing over-prescription of antibiotics. A non-intrusive optical technique called GASMAS (GAs in Scattering Media Absorption Spectroscopy), which has a true potential of being developed into an important complement to other means of detection, was utilized in this work. Water vapor in the frontal sinuses, related to the free gas volume, was studied at around 937 nm in healthy volunteers. The results show a good stability of the GASMAS signals over extended times for the frontal sinuses for all volunteers, showing promising applicability to detect anomalies due to sinusitis. Measurements were also performed following the application of a... (More)
Sinusitis is a very common disease and improved diagnostic tools are desirable also in view of reducing over-prescription of antibiotics. A non-intrusive optical technique called GASMAS (GAs in Scattering Media Absorption Spectroscopy), which has a true potential of being developed into an important complement to other means of detection, was utilized in this work. Water vapor in the frontal sinuses, related to the free gas volume, was studied at around 937 nm in healthy volunteers. The results show a good stability of the GASMAS signals over extended times for the frontal sinuses for all volunteers, showing promising applicability to detect anomalies due to sinusitis. Measurements were also performed following the application of a decongestion spray. No noticeable signal change was observed, which is consistent with the fact that the water vapor concentration is given by the temperature only, and is not influenced by changes in cavity ventilation. Evaluated GASMAS data recorded on 6 consecutive days show signal stability for the left and right frontal sinus in one of the test volonteers. (Less)
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Contribution to journal
publication status
published
subject
in
Journal of Biophotonics
volume
8
issue
11-12
pages
985 - 992
publisher
John Wiley and Sons
external identifiers
  • pmid:25990508
  • wos:000364317500015
  • scopus:84946475470
  • pmid:25990508
ISSN
1864-063X
DOI
10.1002/jbio.201500110
language
English
LU publication?
yes
id
e1f06f9d-14e8-4293-8d0d-6ba6130e3dec (old id 5448608)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25990508?dopt=Abstract
date added to LUP
2016-04-01 10:30:48
date last changed
2021-01-06 07:23:35
@article{e1f06f9d-14e8-4293-8d0d-6ba6130e3dec,
  abstract     = {Sinusitis is a very common disease and improved diagnostic tools are desirable also in view of reducing over-prescription of antibiotics. A non-intrusive optical technique called GASMAS (GAs in Scattering Media Absorption Spectroscopy), which has a true potential of being developed into an important complement to other means of detection, was utilized in this work. Water vapor in the frontal sinuses, related to the free gas volume, was studied at around 937 nm in healthy volunteers. The results show a good stability of the GASMAS signals over extended times for the frontal sinuses for all volunteers, showing promising applicability to detect anomalies due to sinusitis. Measurements were also performed following the application of a decongestion spray. No noticeable signal change was observed, which is consistent with the fact that the water vapor concentration is given by the temperature only, and is not influenced by changes in cavity ventilation. Evaluated GASMAS data recorded on 6 consecutive days show signal stability for the left and right frontal sinus in one of the test volonteers.},
  author       = {Huang, Jing and Zhang, Hao and Li, Tianqi and Lin, Huiying and Svanberg, Katarina and Svanberg, Sune},
  issn         = {1864-063X},
  language     = {eng},
  number       = {11-12},
  pages        = {985--992},
  publisher    = {John Wiley and Sons},
  series       = {Journal of Biophotonics},
  title        = {Assessment of human sinus cavity air volume using tunable diode laser spectroscopy, with application to sinusitis diagnostics.},
  url          = {http://dx.doi.org/10.1002/jbio.201500110},
  doi          = {10.1002/jbio.201500110},
  volume       = {8},
  year         = {2015},
}