Salicylamide and salicylglycine oxidovanadium complexes with insulin-mimetic properties.
Nilsson, Jessica ; Shteinman, Albert A ; Degerman, Eva LU
; Enyedy, Eva A
; Kiss, Tamás
; Behrens, Ulrich
; Rehder, Dieter
and Nordlander, Ebbe
(2011)
In Journal of Inorganic Biochemistry
105.
p.1795-1800
- Abstract
- Reaction of N-(2-hydroxybenzyl)-N-(2-picolyl) glycine (H(2)papy) with VOSO(4) in water gives the oxidovanadium(V) oxido-bridged dimer [{(papy)(VO)}(2) μ-O)] (1). Similarly, reaction of N-(2-hydroxybenzyl) glycine (H(2)glysal) with VOSO(4) gives [(glysal)VO(H(2)O)] (2) and reaction of salicylamide (Hsalam) with VOSO(4) in methanol gives [(salam)(2)VO] (3). The crystal structure of the oxido-bridged complex 1 is reported. The insulin-mimetic activity of all three complexes was evaluated with respect to their ability to phosphorylate protein kinase B (PKB). The speciations of complexes 1 and 2 were studied over the pH range 2-10. Complex 1 shows greater stability over the whole pH range but only 2 and 3 exhibit an insulin-mimetic effect.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2221105
- author
- Nilsson, Jessica
; Shteinman, Albert A
; Degerman, Eva
LU
; Enyedy, Eva A
; Kiss, Tamás
; Behrens, Ulrich
; Rehder, Dieter
and Nordlander, Ebbe
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Inorganic Biochemistry
- volume
- 105
- pages
- 1795 - 1800
- publisher
- Elsevier
- external identifiers
-
- wos:000297904900034
- pmid:22056176
- scopus:82755172879
- pmid:22056176
- ISSN
- 1873-3344
- DOI
- 10.1016/j.jinorgbio.2011.09.022
- language
- English
- LU publication?
- yes
- id
- e20ea554-ad72-4951-bf0f-eba9e4c20833 (old id 2221105)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22056176?dopt=Abstract
- date added to LUP
- 2016-04-04 09:41:22
- date last changed
- 2022-01-29 19:05:01
@article{e20ea554-ad72-4951-bf0f-eba9e4c20833,
abstract = {{Reaction of N-(2-hydroxybenzyl)-N-(2-picolyl) glycine (H(2)papy) with VOSO(4) in water gives the oxidovanadium(V) oxido-bridged dimer [{(papy)(VO)}(2) μ-O)] (1). Similarly, reaction of N-(2-hydroxybenzyl) glycine (H(2)glysal) with VOSO(4) gives [(glysal)VO(H(2)O)] (2) and reaction of salicylamide (Hsalam) with VOSO(4) in methanol gives [(salam)(2)VO] (3). The crystal structure of the oxido-bridged complex 1 is reported. The insulin-mimetic activity of all three complexes was evaluated with respect to their ability to phosphorylate protein kinase B (PKB). The speciations of complexes 1 and 2 were studied over the pH range 2-10. Complex 1 shows greater stability over the whole pH range but only 2 and 3 exhibit an insulin-mimetic effect.}},
author = {{Nilsson, Jessica and Shteinman, Albert A and Degerman, Eva and Enyedy, Eva A and Kiss, Tamás and Behrens, Ulrich and Rehder, Dieter and Nordlander, Ebbe}},
issn = {{1873-3344}},
language = {{eng}},
pages = {{1795--1800}},
publisher = {{Elsevier}},
series = {{Journal of Inorganic Biochemistry}},
title = {{Salicylamide and salicylglycine oxidovanadium complexes with insulin-mimetic properties.}},
url = {{http://dx.doi.org/10.1016/j.jinorgbio.2011.09.022}},
doi = {{10.1016/j.jinorgbio.2011.09.022}},
volume = {{105}},
year = {{2011}},
}