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A melanoma és az agyi áttétképzödés molekuláris háttere

Frida, Katona; Balázs, Murnyák; Marko-Varga, György LU and Tibor, Hortobágyi (2017) In Orvosi Hetilap 158(28). p.1083-1091
Abstract

Malignant melanoma is one of the most aggressive tumors which often gives metastasis to distant organs thereby limiting the chances of survival. Brain metastasis occurs in nearly half of the advanced tumors. In order to improve outcome early diagnosis is important. The discovery and better understanding of genetic and epigenetic changes is essential for developing new effective therapies, which can designate promising therapeutic targets. Melanoma most often is caused by gene mutations of the mitogen-activated protein kinase pathway, the phosphatidylinositol 3-kinase signaling pathway, and the cell cycle regulatory molecules, respectively. The molecular process of brain metastasis has not been fully elucidated. In our review we... (More)

Malignant melanoma is one of the most aggressive tumors which often gives metastasis to distant organs thereby limiting the chances of survival. Brain metastasis occurs in nearly half of the advanced tumors. In order to improve outcome early diagnosis is important. The discovery and better understanding of genetic and epigenetic changes is essential for developing new effective therapies, which can designate promising therapeutic targets. Melanoma most often is caused by gene mutations of the mitogen-activated protein kinase pathway, the phosphatidylinositol 3-kinase signaling pathway, and the cell cycle regulatory molecules, respectively. The molecular process of brain metastasis has not been fully elucidated. In our review we summarize the genetic alterations and molecular mechanisms playing a role in the development of melanoma and its brain metastasis.

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Please use this url to cite or link to this publication:
author
organization
alternative title
Molecular background of the melanoma and the brain metastasis
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Brain metastasis, Melanoma, Metastasis
in
Orvosi Hetilap
volume
158
issue
28
pages
9 pages
publisher
Akademiai Kiado
external identifiers
  • scopus:85022337933
  • wos:000405898900001
ISSN
0030-6002
DOI
10.1556/650.2017.30793
language
Other
LU publication?
yes
id
e214d533-4281-4106-86a3-69945aed619d
date added to LUP
2017-07-25 14:42:34
date last changed
2017-09-18 11:39:23
@article{e214d533-4281-4106-86a3-69945aed619d,
  abstract     = {<p>Malignant melanoma is one of the most aggressive tumors which often gives metastasis to distant organs thereby limiting the chances of survival. Brain metastasis occurs in nearly half of the advanced tumors. In order to improve outcome early diagnosis is important. The discovery and better understanding of genetic and epigenetic changes is essential for developing new effective therapies, which can designate promising therapeutic targets. Melanoma most often is caused by gene mutations of the mitogen-activated protein kinase pathway, the phosphatidylinositol 3-kinase signaling pathway, and the cell cycle regulatory molecules, respectively. The molecular process of brain metastasis has not been fully elucidated. In our review we summarize the genetic alterations and molecular mechanisms playing a role in the development of melanoma and its brain metastasis.</p>},
  author       = {Frida, Katona and Balázs, Murnyák and Marko-Varga, György and Tibor, Hortobágyi},
  issn         = {0030-6002},
  keyword      = {Brain metastasis,Melanoma,Metastasis},
  language     = {mis},
  month        = {07},
  number       = {28},
  pages        = {1083--1091},
  publisher    = {Akademiai Kiado},
  series       = {Orvosi Hetilap},
  title        = {A melanoma és az agyi áttétképzödés molekuláris háttere},
  url          = {http://dx.doi.org/10.1556/650.2017.30793},
  volume       = {158},
  year         = {2017},
}