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Not only oxidized R-(+)- but also S-(-)-limonene is a common cause of contact allergy in dermatitis patients in Europe

Matura, Mihaly; Skold, Maria; Borje, Anna; Andersen, Klaus E.; Bruze, Magnus LU ; Frosch, Peter; Goossens, An; Johansen, Jeanne D.; Svedman, Cecilia LU and White, Ian R., et al. (2006) In Contact Dermatitis 55(5). p.274-279
Abstract
Limonene, one of the most often used fragrance terpenes in any kind of scented products, is prone to air-oxidation. The oxidation products formed have a considerable sensitizing potential. In previous patch test studies on consecutively tested dermatitis patients, oxidized R-limonene has been proven to be a good and frequent indicator of fragrance-related contact allergy. The current study extends these investigations to 6 European clinics of dermatology, where the oxidation mixture of both enantiomers of limonene (R and S) have been tested in 2411 dermatitis patients. Altogether, 63 out of 2411 patients tested (2.6%) reacted to 1 or both the oxidized limonene preparations. Only 2.3% reacted to the oxidized R-limonene and 2.0% to the... (More)
Limonene, one of the most often used fragrance terpenes in any kind of scented products, is prone to air-oxidation. The oxidation products formed have a considerable sensitizing potential. In previous patch test studies on consecutively tested dermatitis patients, oxidized R-limonene has been proven to be a good and frequent indicator of fragrance-related contact allergy. The current study extends these investigations to 6 European clinics of dermatology, where the oxidation mixture of both enantiomers of limonene (R and S) have been tested in 2411 dermatitis patients. Altogether, 63 out of 2411 patients tested (2.6%) reacted to 1 or both the oxidized limonene preparations. Only 2.3% reacted to the oxidized R-limonene and 2.0% to the oxidized S-limonene. In 57% of the cases, simultaneous reactions were observed to both oxidation mixtures. Concomitant reactions to the fragrance mix, colophonium, Myroxylon pereirae, and fragrance-related contact allergy were common in patients reacting to 1 or both the oxidized limonene enantiomers. Our study provides clinical evidence for the importance of oxidation products of limonene in contact allergy. It seems advisable to screen consecutive dermatitis patients with oxidized limonene 3% petrolatum, although this patch test material is not yet commercially available. (Less)
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Contribution to journal
publication status
published
subject
keywords
fragrance allergy, limonene, autoxidation, patch test, reactions, allergic contact dermatitis, cross, hydroperoxides, oxidation, products, fragrance mix
in
Contact Dermatitis
volume
55
issue
5
pages
274 - 279
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • wos:000241110900003
  • scopus:33749581267
ISSN
0105-1873
DOI
10.1111/j.1600-0536.2006.00939.x
language
English
LU publication?
yes
id
e216fa6c-9154-4adf-ac99-efc8232143e7 (old id 685974)
date added to LUP
2007-12-19 13:54:36
date last changed
2019-03-17 03:44:59
@article{e216fa6c-9154-4adf-ac99-efc8232143e7,
  abstract     = {Limonene, one of the most often used fragrance terpenes in any kind of scented products, is prone to air-oxidation. The oxidation products formed have a considerable sensitizing potential. In previous patch test studies on consecutively tested dermatitis patients, oxidized R-limonene has been proven to be a good and frequent indicator of fragrance-related contact allergy. The current study extends these investigations to 6 European clinics of dermatology, where the oxidation mixture of both enantiomers of limonene (R and S) have been tested in 2411 dermatitis patients. Altogether, 63 out of 2411 patients tested (2.6%) reacted to 1 or both the oxidized limonene preparations. Only 2.3% reacted to the oxidized R-limonene and 2.0% to the oxidized S-limonene. In 57% of the cases, simultaneous reactions were observed to both oxidation mixtures. Concomitant reactions to the fragrance mix, colophonium, Myroxylon pereirae, and fragrance-related contact allergy were common in patients reacting to 1 or both the oxidized limonene enantiomers. Our study provides clinical evidence for the importance of oxidation products of limonene in contact allergy. It seems advisable to screen consecutive dermatitis patients with oxidized limonene 3% petrolatum, although this patch test material is not yet commercially available.},
  author       = {Matura, Mihaly and Skold, Maria and Borje, Anna and Andersen, Klaus E. and Bruze, Magnus and Frosch, Peter and Goossens, An and Johansen, Jeanne D. and Svedman, Cecilia and White, Ian R. and Karlberg, Ann-Therese},
  issn         = {0105-1873},
  keyword      = {fragrance allergy,limonene,autoxidation,patch test,reactions,allergic contact dermatitis,cross,hydroperoxides,oxidation,products,fragrance mix},
  language     = {eng},
  number       = {5},
  pages        = {274--279},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {Contact Dermatitis},
  title        = {Not only oxidized R-(+)- but also S-(-)-limonene is a common cause of contact allergy in dermatitis patients in Europe},
  url          = {http://dx.doi.org/10.1111/j.1600-0536.2006.00939.x},
  volume       = {55},
  year         = {2006},
}