The DEK oncoprotein and its emerging roles in gene regulation.
(2015) In Leukemia 29(8). p.1632-1636- Abstract
- The DEK oncogene is highly expressed in cells from most human tissues and overexpressed in a large and growing number of cancers. It also fuses with the NUP214 gene to form the DEK-NUP214 fusion gene in a subset of acute myeloid leukemia. Originally characterized as a member of this translocation, DEK has since been implicated in epigenetic and transcriptional regulation but its role in these processes is still elusive and intriguingly complex. Similarly multifaceted is its contribution to cellular transformation, affecting multiple cellular processes such as self-renewal, proliferation, differentiation, senescence and apoptosis. Recently, the roles of the DEK and DEK-NUP214 proteins have been elucidated by global analysis of DNA binding... (More)
- The DEK oncogene is highly expressed in cells from most human tissues and overexpressed in a large and growing number of cancers. It also fuses with the NUP214 gene to form the DEK-NUP214 fusion gene in a subset of acute myeloid leukemia. Originally characterized as a member of this translocation, DEK has since been implicated in epigenetic and transcriptional regulation but its role in these processes is still elusive and intriguingly complex. Similarly multifaceted is its contribution to cellular transformation, affecting multiple cellular processes such as self-renewal, proliferation, differentiation, senescence and apoptosis. Recently, the roles of the DEK and DEK-NUP214 proteins have been elucidated by global analysis of DNA binding and gene expression as well as multiple functional studies. This review outlines recent advances in the understanding of the basic functions of the DEK protein and its role in leukemogenesis.Leukemia accepted article preview online, 13 March 2015. doi:10.1038/leu.2015.72. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/5261709
- author
- Sandén, Carl LU and Gullberg, Urban LU
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Leukemia
- volume
- 29
- issue
- 8
- pages
- 1632 - 1636
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:25765544
- wos:000360937200002
- scopus:84938995946
- pmid:25765544
- ISSN
- 1476-5551
- DOI
- 10.1038/leu.2015.72
- language
- English
- LU publication?
- yes
- id
- e2418869-5457-48b5-a2ff-c84e08b763de (old id 5261709)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/25765544?dopt=Abstract
- date added to LUP
- 2016-04-01 10:22:36
- date last changed
- 2022-05-05 21:28:08
@article{e2418869-5457-48b5-a2ff-c84e08b763de,
abstract = {{The DEK oncogene is highly expressed in cells from most human tissues and overexpressed in a large and growing number of cancers. It also fuses with the NUP214 gene to form the DEK-NUP214 fusion gene in a subset of acute myeloid leukemia. Originally characterized as a member of this translocation, DEK has since been implicated in epigenetic and transcriptional regulation but its role in these processes is still elusive and intriguingly complex. Similarly multifaceted is its contribution to cellular transformation, affecting multiple cellular processes such as self-renewal, proliferation, differentiation, senescence and apoptosis. Recently, the roles of the DEK and DEK-NUP214 proteins have been elucidated by global analysis of DNA binding and gene expression as well as multiple functional studies. This review outlines recent advances in the understanding of the basic functions of the DEK protein and its role in leukemogenesis.Leukemia accepted article preview online, 13 March 2015. doi:10.1038/leu.2015.72.}},
author = {{Sandén, Carl and Gullberg, Urban}},
issn = {{1476-5551}},
language = {{eng}},
number = {{8}},
pages = {{1632--1636}},
publisher = {{Nature Publishing Group}},
series = {{Leukemia}},
title = {{The DEK oncoprotein and its emerging roles in gene regulation.}},
url = {{https://lup.lub.lu.se/search/files/1789733/8230154.pdf}},
doi = {{10.1038/leu.2015.72}},
volume = {{29}},
year = {{2015}},
}