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Hematopoietic Stem Cell Donors' Experiences of Information and Side-Effects During the First Year After Donation-A Swedish National Study

Kisch, Annika M LU orcid ; Winterling, Jeanette LU ; Hägglund, Hans ; Larfors, Gunnar ; Lenhoff, Stig LU and Pahnke, Simon (2025) In Journal of Clinical Apheresis 40(4).
Abstract

The aim was to describe hematopoietic stem cell (HSC) donors' experiences focusing on information and side effects during the first year after donation. Our prospective Swedish cohort study with adult HSC donors was performed from 2019 to 2022, with questionnaires at four time points from before until 12 months after donation. 173 unrelated and 68 related donors participated, and the majority donated peripheral blood stem cells. All but one rated their donation experience as good or very good. At least one side effect was reported by 83% of participants. Six donors (2.5%) experienced either numerous side effects, at least one severe side effect, or prolonged side effects. Satisfaction with information was lower among donors having... (More)

The aim was to describe hematopoietic stem cell (HSC) donors' experiences focusing on information and side effects during the first year after donation. Our prospective Swedish cohort study with adult HSC donors was performed from 2019 to 2022, with questionnaires at four time points from before until 12 months after donation. 173 unrelated and 68 related donors participated, and the majority donated peripheral blood stem cells. All but one rated their donation experience as good or very good. At least one side effect was reported by 83% of participants. Six donors (2.5%) experienced either numerous side effects, at least one severe side effect, or prolonged side effects. Satisfaction with information was lower among donors having severe side effects and bone marrow donors. Overall satisfaction with the donation was lower among donors having severe side effects and unrelated donors. Donors were generally satisfied with the pre-donation information. Most experienced side effects that resolved within 2 weeks, which strengthens the case for unchanged donor follow-up 1 month after donation, with individualized follow-up for donors with persistent symptoms. Enhanced information regarding the risk of more severe or prolonged side effects appears warranted, and its effect on donor satisfaction should be evaluated.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Clinical Apheresis
volume
40
issue
4
article number
e70050
publisher
Wiley-Liss Inc.
external identifiers
  • scopus:105013363423
  • pmid:40817620
ISSN
0733-2459
DOI
10.1002/jca.70050
language
English
LU publication?
yes
additional info
© 2025 The Author(s). Journal of Clinical Apheresis published by Wiley Periodicals LLC.
id
e2d8c8ab-e33f-4d75-a8b4-12ad83f0abac
date added to LUP
2025-08-18 11:10:59
date last changed
2025-12-11 13:17:16
@article{e2d8c8ab-e33f-4d75-a8b4-12ad83f0abac,
  abstract     = {{<p>The aim was to describe hematopoietic stem cell (HSC) donors' experiences focusing on information and side effects during the first year after donation. Our prospective Swedish cohort study with adult HSC donors was performed from 2019 to 2022, with questionnaires at four time points from before until 12 months after donation. 173 unrelated and 68 related donors participated, and the majority donated peripheral blood stem cells. All but one rated their donation experience as good or very good. At least one side effect was reported by 83% of participants. Six donors (2.5%) experienced either numerous side effects, at least one severe side effect, or prolonged side effects. Satisfaction with information was lower among donors having severe side effects and bone marrow donors. Overall satisfaction with the donation was lower among donors having severe side effects and unrelated donors. Donors were generally satisfied with the pre-donation information. Most experienced side effects that resolved within 2 weeks, which strengthens the case for unchanged donor follow-up 1 month after donation, with individualized follow-up for donors with persistent symptoms. Enhanced information regarding the risk of more severe or prolonged side effects appears warranted, and its effect on donor satisfaction should be evaluated.</p>}},
  author       = {{Kisch, Annika M and Winterling, Jeanette and Hägglund, Hans and Larfors, Gunnar and Lenhoff, Stig and Pahnke, Simon}},
  issn         = {{0733-2459}},
  language     = {{eng}},
  number       = {{4}},
  publisher    = {{Wiley-Liss Inc.}},
  series       = {{Journal of Clinical Apheresis}},
  title        = {{Hematopoietic Stem Cell Donors' Experiences of Information and Side-Effects During the First Year After Donation-A Swedish National Study}},
  url          = {{http://dx.doi.org/10.1002/jca.70050}},
  doi          = {{10.1002/jca.70050}},
  volume       = {{40}},
  year         = {{2025}},
}