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Inheritance of MHC class II genes in IDDM studied in population-based affected and control families

Kockum, I. ; Wassmuth, R. ; Holmberg, E. ; Michelsen, B. and Lernmark, Å LU (1994) In Diabetologia 37(11). p.1105-1112
Abstract

The transmission of HLA-DR and DQ was compared between 46 families with at least one child affected by insulin dependent diabetes mellitis (IDDM) and 43 healthy control families. In the patient families, there was an increased transmission of DR4 (p<0.025) and DQB1*0302 (p<0.01) from both parents to the index patient. There was an increased transmission of DQB1*0302 (p<0.03) from the mothers only. The non-inherited maternal haplotypes showed a significantly decreased frequency (p<0.01) of positively associated haplotypes (DR4-DQA1* 0301-DQB1*0302, DR3-DQA1*0501-DQB1*0201) compared to all parental haplotypes in the control families. In the control families neither transmission rates nor frequencies of non-inherited haplotypes... (More)

The transmission of HLA-DR and DQ was compared between 46 families with at least one child affected by insulin dependent diabetes mellitis (IDDM) and 43 healthy control families. In the patient families, there was an increased transmission of DR4 (p<0.025) and DQB1*0302 (p<0.01) from both parents to the index patient. There was an increased transmission of DQB1*0302 (p<0.03) from the mothers only. The non-inherited maternal haplotypes showed a significantly decreased frequency (p<0.01) of positively associated haplotypes (DR4-DQA1* 0301-DQB1*0302, DR3-DQA1*0501-DQB1*0201) compared to all parental haplotypes in the control families. In the control families neither transmission rates nor frequencies of non-inherited haplotypes differed from those expected in the control families. In conclusion, the observed reduction of IDDM-positively associated haplotypes in patient non-inherited maternal haplotypes, but not in non-inherited paternal haplotypes, suggests that tolerance during fetal life to maternal non-inherited HLA molecules may be important to diabetes development.

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author
; ; ; and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
HLA-DQ, HLA-DR, non-inherited maternal haplotypes, non-inherited paternal haplotypes, Transmission rates
in
Diabetologia
volume
37
issue
11
pages
1105 - 1112
publisher
Springer
external identifiers
  • pmid:7867882
  • scopus:0028032269
ISSN
0012-186X
DOI
10.1007/BF00418374
language
English
LU publication?
no
id
e2ec7101-e383-4c25-82b4-463f93fd7ac8
date added to LUP
2019-09-11 09:08:00
date last changed
2020-01-13 02:20:52
@article{e2ec7101-e383-4c25-82b4-463f93fd7ac8,
  abstract     = {<p>The transmission of HLA-DR and DQ was compared between 46 families with at least one child affected by insulin dependent diabetes mellitis (IDDM) and 43 healthy control families. In the patient families, there was an increased transmission of DR4 (p&lt;0.025) and DQB1*0302 (p&lt;0.01) from both parents to the index patient. There was an increased transmission of DQB1*0302 (p&lt;0.03) from the mothers only. The non-inherited maternal haplotypes showed a significantly decreased frequency (p&lt;0.01) of positively associated haplotypes (DR4-DQA1* 0301-DQB1*0302, DR3-DQA1*0501-DQB1*0201) compared to all parental haplotypes in the control families. In the control families neither transmission rates nor frequencies of non-inherited haplotypes differed from those expected in the control families. In conclusion, the observed reduction of IDDM-positively associated haplotypes in patient non-inherited maternal haplotypes, but not in non-inherited paternal haplotypes, suggests that tolerance during fetal life to maternal non-inherited HLA molecules may be important to diabetes development.</p>},
  author       = {Kockum, I. and Wassmuth, R. and Holmberg, E. and Michelsen, B. and Lernmark, Å},
  issn         = {0012-186X},
  language     = {eng},
  month        = {11},
  number       = {11},
  pages        = {1105--1112},
  publisher    = {Springer},
  series       = {Diabetologia},
  title        = {Inheritance of MHC class II genes in IDDM studied in population-based affected and control families},
  url          = {http://dx.doi.org/10.1007/BF00418374},
  doi          = {10.1007/BF00418374},
  volume       = {37},
  year         = {1994},
}