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Fatigue trajectories during pediatric ALL therapy are associated with fatigue after treatment: a national longitudinal cohort study

Irestorm, Elin LU orcid ; Steur, Lindsay M.H ; Kaspers, Gertjan J. L. ; Van Eijkelenburg, Natasha K.A. ; van der Sluis, Inge Margriet ; Dors, Natasja ; van den Bos, Cor ; Tissing, Wim J E ; Grootenhuis, Martha A. and van Litsenburg, Raphaele R.L. (2023) In Supportive Care in Cancer 31(1). p.1-9
Abstract
Objective: Fatigue is one of the most prevalent and distressing symptoms reported by survivors of childhood cancer. There is currently a lack of longitudinal studies on cancer-related fatigue, and especially on the relationship between the course of fatigue during treatment and fatigue at follow-up. The purpose of the current study was therefore to investigate if the
course of fatigue during treatment, treatment intensity, serious adverse events, sex, or age at diagnosis are associated with cancer-related fatigue after treatment.
Methods: Participants were 92 children and adolescents diagnosed with acute lymphoblastic leukemia (mean age at diagnosis was 6.26 years). Fatigue was measured with PedsQL multidimensional fatigue scale... (More)
Objective: Fatigue is one of the most prevalent and distressing symptoms reported by survivors of childhood cancer. There is currently a lack of longitudinal studies on cancer-related fatigue, and especially on the relationship between the course of fatigue during treatment and fatigue at follow-up. The purpose of the current study was therefore to investigate if the
course of fatigue during treatment, treatment intensity, serious adverse events, sex, or age at diagnosis are associated with cancer-related fatigue after treatment.
Methods: Participants were 92 children and adolescents diagnosed with acute lymphoblastic leukemia (mean age at diagnosis was 6.26 years). Fatigue was measured with PedsQL multidimensional fatigue scale proxy reports 5 months after diagnosis,12 months after diagnosis, 24 months after diagnosis, and at follow-up 12 months after end of treatment. The effect of patient
and treatment characteristics on fatigue reported at follow-up was tested through logistic regression analyses.
Results: The course of fatigue during treatment signifcantly predicted fatigue reported at follow-up for general fatigue (p=.038, OR=9.20), sleep/rest fatigue (p=.011, OR=15.48), and cognitive fatigue (pConclusions The fndings demonstrate that fatigue reported during treatment can predict fatigue at follow-up. These results stress the need for longitudinal assessments. Healthcare professionals need to be aware that pediatric patients who are fatigued during treatment need to receive additional attention and timely interventions since cancer-related fatigue will not resolve by itself in the frst year after end of treatment. (Less)
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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Supportive Care in Cancer
volume
31
issue
1
article number
1
pages
1 - 9
publisher
Springer
external identifiers
  • scopus:85143912146
  • pmid:36512099
ISSN
1433-7339
DOI
10.1007/s00520-022-07456-x
language
English
LU publication?
yes
id
e357c05b-c9f1-419f-ac5e-ad4a8bf36d00
date added to LUP
2022-12-13 13:31:10
date last changed
2023-03-15 03:00:13
@article{e357c05b-c9f1-419f-ac5e-ad4a8bf36d00,
  abstract     = {{Objective: Fatigue is one of the most prevalent and distressing symptoms reported by survivors of childhood cancer. There is currently a lack of longitudinal studies on cancer-related fatigue, and especially on the relationship between the course of fatigue during treatment and fatigue at follow-up. The purpose of the current study was therefore to investigate if the <br/>course of fatigue during treatment, treatment intensity, serious adverse events, sex, or age at diagnosis are associated with cancer-related fatigue after treatment.<br/>Methods: Participants were 92 children and adolescents diagnosed with acute lymphoblastic leukemia (mean age at diagnosis was 6.26 years). Fatigue was measured with PedsQL multidimensional fatigue scale proxy reports 5 months after diagnosis,12 months after diagnosis, 24 months after diagnosis, and at follow-up 12 months after end of treatment. The effect of patient <br/>and treatment characteristics on fatigue reported at follow-up was tested through logistic regression analyses.<br/>Results: The course of fatigue during treatment signifcantly predicted fatigue reported at follow-up for general fatigue (p=.038, OR=9.20), sleep/rest fatigue (p=.011, OR=15.48), and cognitive fatigue (pConclusions The fndings demonstrate that fatigue reported during treatment can predict fatigue at follow-up. These results stress the need for longitudinal assessments. Healthcare professionals need to be aware that pediatric patients who are fatigued during treatment need to receive additional attention and timely interventions since cancer-related fatigue will not resolve by itself in the frst year after end of treatment.}},
  author       = {{Irestorm, Elin and Steur, Lindsay M.H and Kaspers, Gertjan J. L. and Van Eijkelenburg, Natasha K.A. and van der Sluis, Inge Margriet and Dors, Natasja and van den Bos, Cor and Tissing, Wim J E and Grootenhuis, Martha A. and van Litsenburg, Raphaele R.L.}},
  issn         = {{1433-7339}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{1--9}},
  publisher    = {{Springer}},
  series       = {{Supportive Care in Cancer}},
  title        = {{Fatigue trajectories during pediatric ALL therapy are associated with fatigue after treatment: a national longitudinal cohort study}},
  url          = {{http://dx.doi.org/10.1007/s00520-022-07456-x}},
  doi          = {{10.1007/s00520-022-07456-x}},
  volume       = {{31}},
  year         = {{2023}},
}