Ion channels, electrical activity and insulin secretion
(1994) In Diabete & metabolisme 20(2). p.138-145- Abstract
- The insulin-secreting pancreatic beta cell is electrically excitable and changes in the membrane potential play an important role in coupling the metabolism of glucose (and other nutrient secretagogues) to the discharge of the insulin-containing granule. The application of the patch-clamp technique, which permits the recordings of the minute currents associated with the opening of individual ion channels, to pancreatic islet cells has revolutionized our understanding of the beta cell electrophysiology. Here we review some of the recent progress in the field. The properties of functionally important ion channels are described and their possible roles are discussed.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1107727
- author
- Rorsman, Patrik LU ; Bokvist, K ; Ammala, C ; Eliasson, L ; Renström, Erik LU and Gabel, J
- organization
- publishing date
- 1994
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Diabete & metabolisme
- volume
- 20
- issue
- 2
- pages
- 138 - 145
- publisher
- Elsevier Masson SAS
- external identifiers
-
- pmid:7528694
- scopus:0028619809
- ISSN
- 0338-1684
- language
- English
- LU publication?
- yes
- id
- e38110c9-da53-4eb0-a659-b7782813d755 (old id 1107727)
- date added to LUP
- 2016-04-01 16:30:15
- date last changed
- 2021-03-21 05:02:00
@article{e38110c9-da53-4eb0-a659-b7782813d755,
abstract = {{The insulin-secreting pancreatic beta cell is electrically excitable and changes in the membrane potential play an important role in coupling the metabolism of glucose (and other nutrient secretagogues) to the discharge of the insulin-containing granule. The application of the patch-clamp technique, which permits the recordings of the minute currents associated with the opening of individual ion channels, to pancreatic islet cells has revolutionized our understanding of the beta cell electrophysiology. Here we review some of the recent progress in the field. The properties of functionally important ion channels are described and their possible roles are discussed.}},
author = {{Rorsman, Patrik and Bokvist, K and Ammala, C and Eliasson, L and Renström, Erik and Gabel, J}},
issn = {{0338-1684}},
language = {{eng}},
number = {{2}},
pages = {{138--145}},
publisher = {{Elsevier Masson SAS}},
series = {{Diabete & metabolisme}},
title = {{Ion channels, electrical activity and insulin secretion}},
volume = {{20}},
year = {{1994}},
}