Low MSP-1 haplotype diversity in the West Palearctic population of the avian malaria parasite Plasmodium relictum
(2021) In Malaria Journal 20(1).- Abstract
Background: Although avian Plasmodium species are widespread and common across the globe, limited data exist on how genetically variable their populations are. Here, the hypothesis that the avian blood parasite Plasmodium relictum exhibits very low genetic diversity in its Western Palearctic transmission area (from Morocco to Sweden in the north and Transcaucasia in the east) was tested. Methods: The genetic diversity of Plasmodium relictum was investigated by sequencing a portion (block 14) of the fast-evolving merozoite surface protein 1 (MSP1) gene in 75 different P. relictum infections from 36 host species. Furthermore, the full-length MSP1 sequences representing the common block 14 allele was sequenced in order to investigate if... (More)
Background: Although avian Plasmodium species are widespread and common across the globe, limited data exist on how genetically variable their populations are. Here, the hypothesis that the avian blood parasite Plasmodium relictum exhibits very low genetic diversity in its Western Palearctic transmission area (from Morocco to Sweden in the north and Transcaucasia in the east) was tested. Methods: The genetic diversity of Plasmodium relictum was investigated by sequencing a portion (block 14) of the fast-evolving merozoite surface protein 1 (MSP1) gene in 75 different P. relictum infections from 36 host species. Furthermore, the full-length MSP1 sequences representing the common block 14 allele was sequenced in order to investigate if additional variation could be found outside block 14. Results: The majority (72 of 75) of the sequenced infections shared the same MSP1 allele. This common allele has previously been found to be the dominant allele transmitted in Europe. Conclusion: The results corroborate earlier findings derived from a limited dataset that the globally transmitted malaria parasite P. relictum exhibits very low genetic diversity in its Western Palearctic transmission area. This is likely the result of a recent introduction event or a selective sweep.
(Less)
- author
- organization
- publishing date
- 2021-12
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Avian malaria, Haemosporida, Host specificity, Merozoite surface protein 1, Parasite population structure, Plasmodium relictum
- in
- Malaria Journal
- volume
- 20
- issue
- 1
- article number
- 265
- publisher
- BioMed Central (BMC)
- external identifiers
-
- pmid:34118950
- scopus:85107831135
- ISSN
- 1475-2875
- DOI
- 10.1186/s12936-021-03799-8
- language
- English
- LU publication?
- yes
- id
- e3b09244-5a1a-418c-a97a-8262138297e7
- date added to LUP
- 2021-06-29 10:17:09
- date last changed
- 2024-06-15 13:04:35
@article{e3b09244-5a1a-418c-a97a-8262138297e7,
abstract = {{<p>Background: Although avian Plasmodium species are widespread and common across the globe, limited data exist on how genetically variable their populations are. Here, the hypothesis that the avian blood parasite Plasmodium relictum exhibits very low genetic diversity in its Western Palearctic transmission area (from Morocco to Sweden in the north and Transcaucasia in the east) was tested. Methods: The genetic diversity of Plasmodium relictum was investigated by sequencing a portion (block 14) of the fast-evolving merozoite surface protein 1 (MSP1) gene in 75 different P. relictum infections from 36 host species. Furthermore, the full-length MSP1 sequences representing the common block 14 allele was sequenced in order to investigate if additional variation could be found outside block 14. Results: The majority (72 of 75) of the sequenced infections shared the same MSP1 allele. This common allele has previously been found to be the dominant allele transmitted in Europe. Conclusion: The results corroborate earlier findings derived from a limited dataset that the globally transmitted malaria parasite P. relictum exhibits very low genetic diversity in its Western Palearctic transmission area. This is likely the result of a recent introduction event or a selective sweep.</p>}},
author = {{Hellgren, Olof and Kelbskopf, Victor and Ellis, Vincenzo A. and Ciloglu, Arif and Duc, Mélanie and Huang, Xi and Lopes, Ricardo J. and Mata, Vanessa A. and Aghayan, Sargis A. and Inci, Abdullah and Drovetski, Sergei V.}},
issn = {{1475-2875}},
keywords = {{Avian malaria; Haemosporida; Host specificity; Merozoite surface protein 1; Parasite population structure; Plasmodium relictum}},
language = {{eng}},
number = {{1}},
publisher = {{BioMed Central (BMC)}},
series = {{Malaria Journal}},
title = {{Low MSP-1 haplotype diversity in the West Palearctic population of the avian malaria parasite Plasmodium relictum}},
url = {{http://dx.doi.org/10.1186/s12936-021-03799-8}},
doi = {{10.1186/s12936-021-03799-8}},
volume = {{20}},
year = {{2021}},
}