Nitrous oxide for monitoring fluid absorption in volunteers.
(2007) In British Journal of Anaesthesia 98(1). p.53-59- Abstract (Swedish)
- Background: We studied whether nitrous oxide (N(2)O) added to a fluid allows the infused volume to be quantified by measuring N(2)O in the expired air during normal breathing. If so, N(2)O might serve as a tracer of fluid absorption during endoscopic surgery.
Methods: Twelve male volunteers received continuous and intermittent i.v. infusions (5-45 min) of fluid containing 40 ml litre(-1) of N(2)O. Breath N(2)O and CO(2) concentrations were measured every second via a flared nasal cannula, a standard nasal cannula, or a Hudson mask.
Results: An expression for the amount of infused fluid was obtained by calculating the area under the N(2)O concentration-time curve for samples representative for exhalation (CO(2)>median)... (More) - Background: We studied whether nitrous oxide (N(2)O) added to a fluid allows the infused volume to be quantified by measuring N(2)O in the expired air during normal breathing. If so, N(2)O might serve as a tracer of fluid absorption during endoscopic surgery.
Methods: Twelve male volunteers received continuous and intermittent i.v. infusions (5-45 min) of fluid containing 40 ml litre(-1) of N(2)O. Breath N(2)O and CO(2) concentrations were measured every second via a flared nasal cannula, a standard nasal cannula, or a Hudson mask.
Results: An expression for the amount of infused fluid was obtained by calculating the area under the N(2)O concentration-time curve for samples representative for exhalation (CO(2)>median) and then dividing this area by the median CO(2) for the remaining samples. The N(2)O method then estimated fluid volumes of between 50 and 1400 ml within a 95% prediction interval of +/-200 ml. There were differences of up to 14% in results between the airway devices tested, but the volunteers preferred the flared nasal cannula. N(2)O showed a distinctly higher 3 min variability during intermittent infusion, which could indicate whether fluid absorption is directly intravascular or extravascular. No adverse effects were seen.
Conclusions: N(2)O method does not require forced end-expiratory breath sampling but still predicts an administered fluid volume with high precision. N(2)O variability can probably be used to distinguish immediately between intravascular and perivesical fluid absorption during surgery. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/e3be7c66-cf39-438c-9220-8033cb2bd778
- author
- Piros, D LU ; Drobin, D and Hahn, R G
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- in
- British Journal of Anaesthesia
- volume
- 98
- issue
- 1
- pages
- 53 - 59
- publisher
- Elsevier
- external identifiers
-
- scopus:33845390625
- ISSN
- 1471-6771
- DOI
- 10.1093/bja/ael311
- language
- Swedish
- LU publication?
- no
- id
- e3be7c66-cf39-438c-9220-8033cb2bd778
- date added to LUP
- 2022-03-15 16:45:36
- date last changed
- 2024-01-03 09:23:32
@article{e3be7c66-cf39-438c-9220-8033cb2bd778,
abstract = {{Background: We studied whether nitrous oxide (N(2)O) added to a fluid allows the infused volume to be quantified by measuring N(2)O in the expired air during normal breathing. If so, N(2)O might serve as a tracer of fluid absorption during endoscopic surgery.<br/><br/>Methods: Twelve male volunteers received continuous and intermittent i.v. infusions (5-45 min) of fluid containing 40 ml litre(-1) of N(2)O. Breath N(2)O and CO(2) concentrations were measured every second via a flared nasal cannula, a standard nasal cannula, or a Hudson mask.<br/><br/>Results: An expression for the amount of infused fluid was obtained by calculating the area under the N(2)O concentration-time curve for samples representative for exhalation (CO(2)>median) and then dividing this area by the median CO(2) for the remaining samples. The N(2)O method then estimated fluid volumes of between 50 and 1400 ml within a 95% prediction interval of +/-200 ml. There were differences of up to 14% in results between the airway devices tested, but the volunteers preferred the flared nasal cannula. N(2)O showed a distinctly higher 3 min variability during intermittent infusion, which could indicate whether fluid absorption is directly intravascular or extravascular. No adverse effects were seen.<br/><br/>Conclusions: N(2)O method does not require forced end-expiratory breath sampling but still predicts an administered fluid volume with high precision. N(2)O variability can probably be used to distinguish immediately between intravascular and perivesical fluid absorption during surgery.}},
author = {{Piros, D and Drobin, D and Hahn, R G}},
issn = {{1471-6771}},
language = {{swe}},
number = {{1}},
pages = {{53--59}},
publisher = {{Elsevier}},
series = {{British Journal of Anaesthesia}},
title = {{Nitrous oxide for monitoring fluid absorption in volunteers.}},
url = {{http://dx.doi.org/10.1093/bja/ael311}},
doi = {{10.1093/bja/ael311}},
volume = {{98}},
year = {{2007}},
}