Review of structural design guiding the development of lipid nanoparticles for nucleic acid delivery
(2023) In Current Opinion in Colloid and Interface Science 66.- Abstract
Lipid nanoparticles (LNPs) are the most versatile and successful gene delivery systems, notably highlighted by their use in vaccines against COVID-19. LNPs have a well-defined core–shell structure, each region with its own distinctive compositions, suited for a wide range of in vivo delivery applications. Here, we discuss how a detailed knowledge of LNP structure can guide LNP formulation to improve the efficiency of delivery of their nucleic acid payload. Perspectives are detailed on how LNP structural design can guide more efficient nucleic acid transfection. Views on key physical characterization techniques needed for such developments are outlined including opinions on biophysical approaches both correlating structure with... (More)
Lipid nanoparticles (LNPs) are the most versatile and successful gene delivery systems, notably highlighted by their use in vaccines against COVID-19. LNPs have a well-defined core–shell structure, each region with its own distinctive compositions, suited for a wide range of in vivo delivery applications. Here, we discuss how a detailed knowledge of LNP structure can guide LNP formulation to improve the efficiency of delivery of their nucleic acid payload. Perspectives are detailed on how LNP structural design can guide more efficient nucleic acid transfection. Views on key physical characterization techniques needed for such developments are outlined including opinions on biophysical approaches both correlating structure with functionality in biological fluids and improving their ability to escape the endosome and deliver they payload.
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- author
- Cárdenas, Marité ; Campbell, Richard A. ; Yanez Arteta, Marianna ; Lawrence, M. Jayne and Sebastiani, Federica LU
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Cationic ionizable lipids, Lipid nanoparticles, Nucleic acid delicery, Structure-function
- in
- Current Opinion in Colloid and Interface Science
- volume
- 66
- article number
- 101705
- publisher
- Elsevier
- external identifiers
-
- scopus:85162178818
- ISSN
- 1359-0294
- DOI
- 10.1016/j.cocis.2023.101705
- language
- English
- LU publication?
- yes
- id
- e3cc219f-0798-48ed-ad48-f6f65cc9e9e0
- date added to LUP
- 2023-09-11 12:40:46
- date last changed
- 2023-09-11 13:30:00
@article{e3cc219f-0798-48ed-ad48-f6f65cc9e9e0,
abstract = {{<p>Lipid nanoparticles (LNPs) are the most versatile and successful gene delivery systems, notably highlighted by their use in vaccines against COVID-19. LNPs have a well-defined core–shell structure, each region with its own distinctive compositions, suited for a wide range of in vivo delivery applications. Here, we discuss how a detailed knowledge of LNP structure can guide LNP formulation to improve the efficiency of delivery of their nucleic acid payload. Perspectives are detailed on how LNP structural design can guide more efficient nucleic acid transfection. Views on key physical characterization techniques needed for such developments are outlined including opinions on biophysical approaches both correlating structure with functionality in biological fluids and improving their ability to escape the endosome and deliver they payload.</p>}},
author = {{Cárdenas, Marité and Campbell, Richard A. and Yanez Arteta, Marianna and Lawrence, M. Jayne and Sebastiani, Federica}},
issn = {{1359-0294}},
keywords = {{Cationic ionizable lipids; Lipid nanoparticles; Nucleic acid delicery; Structure-function}},
language = {{eng}},
publisher = {{Elsevier}},
series = {{Current Opinion in Colloid and Interface Science}},
title = {{Review of structural design guiding the development of lipid nanoparticles for nucleic acid delivery}},
url = {{http://dx.doi.org/10.1016/j.cocis.2023.101705}},
doi = {{10.1016/j.cocis.2023.101705}},
volume = {{66}},
year = {{2023}},
}