Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Antibodies to citrullinated peptides in serum and saliva in patients with rheumatoid arthritis and their association to periodontitis

Svärd, Anna ; Renvert, Stefan ; Berglund, Johan Sanmartin ; Persson, Rutger G. and Söderlin, Maria LU (2020) In Clinical and Experimental Rheumatology 38(4). p.699-704
Abstract

Objective A connection between prevalence of rheumatoid arthritis (RA) and periodontitis has been reported. The hypothesis for this association involves increased citrullination in the oral mucosa in patients with periodontitis. Whether ongoing periodontitis has an effect on IgA antibodies to citrullinated peptides (ACPA) in saliva is unknown. We studied IgA ACPA in saliva and serum and their relation to periodontitis and smoking in a population-based elderly RA cohort. Methods A population-based cohort of patients with RA ≥61 years of age (n=132) was examined by rheumatologists and a dental hygienist. Analyses of IgG ACPA in serum and IgA ACPA in serum and saliva were performed. The presence of ACPA was compared in patients with RA... (More)

Objective A connection between prevalence of rheumatoid arthritis (RA) and periodontitis has been reported. The hypothesis for this association involves increased citrullination in the oral mucosa in patients with periodontitis. Whether ongoing periodontitis has an effect on IgA antibodies to citrullinated peptides (ACPA) in saliva is unknown. We studied IgA ACPA in saliva and serum and their relation to periodontitis and smoking in a population-based elderly RA cohort. Methods A population-based cohort of patients with RA ≥61 years of age (n=132) was examined by rheumatologists and a dental hygienist. Analyses of IgG ACPA in serum and IgA ACPA in serum and saliva were performed. The presence of ACPA was compared in patients with RA with and without periodontitis. Results IgA ACPA in serum occurred in 35% of RA patients with periodontitis and in 43% of RA patients without periodontitis (p=0.740). IgG ACPA in serum was found in 66% of RA patients with periodontitis, and in 69% without periodontitis (p=0.740). IgA ACPA in saliva occurred in 20% with periodontitis and 55% without periodontitis (p=0.062). A logistic regression analysis adjusting for age, gender and smoking gave an odds ratio (OR) of 0.456 (95% CI=0.183-1.137, p=0.092) for saliva IgA ACPA positive individuals to have periodontitis. Conclusion IgA ACPA in serum or saliva was not more common in RA patients with periodontitis. This implies that local production of ACPA by the oral mucosa is not enhanced by periodontal inflammation, in patients with established RA.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Anti-citrullinated peptide antibodies, Epidemiology, Periodontitis, Rheumatoid arthritis, Smoking
in
Clinical and Experimental Rheumatology
volume
38
issue
4
pages
6 pages
publisher
Pacini
external identifiers
  • pmid:31820729
  • scopus:85088878956
ISSN
0392-856X
language
English
LU publication?
yes
id
e3d20dfe-fd0d-42f2-bf92-1cf46b37d749
date added to LUP
2021-01-12 13:47:43
date last changed
2024-03-20 23:54:12
@article{e3d20dfe-fd0d-42f2-bf92-1cf46b37d749,
  abstract     = {{<p>Objective A connection between prevalence of rheumatoid arthritis (RA) and periodontitis has been reported. The hypothesis for this association involves increased citrullination in the oral mucosa in patients with periodontitis. Whether ongoing periodontitis has an effect on IgA antibodies to citrullinated peptides (ACPA) in saliva is unknown. We studied IgA ACPA in saliva and serum and their relation to periodontitis and smoking in a population-based elderly RA cohort. Methods A population-based cohort of patients with RA ≥61 years of age (n=132) was examined by rheumatologists and a dental hygienist. Analyses of IgG ACPA in serum and IgA ACPA in serum and saliva were performed. The presence of ACPA was compared in patients with RA with and without periodontitis. Results IgA ACPA in serum occurred in 35% of RA patients with periodontitis and in 43% of RA patients without periodontitis (p=0.740). IgG ACPA in serum was found in 66% of RA patients with periodontitis, and in 69% without periodontitis (p=0.740). IgA ACPA in saliva occurred in 20% with periodontitis and 55% without periodontitis (p=0.062). A logistic regression analysis adjusting for age, gender and smoking gave an odds ratio (OR) of 0.456 (95% CI=0.183-1.137, p=0.092) for saliva IgA ACPA positive individuals to have periodontitis. Conclusion IgA ACPA in serum or saliva was not more common in RA patients with periodontitis. This implies that local production of ACPA by the oral mucosa is not enhanced by periodontal inflammation, in patients with established RA.</p>}},
  author       = {{Svärd, Anna and Renvert, Stefan and Berglund, Johan Sanmartin and Persson, Rutger G. and Söderlin, Maria}},
  issn         = {{0392-856X}},
  keywords     = {{Anti-citrullinated peptide antibodies; Epidemiology; Periodontitis; Rheumatoid arthritis; Smoking}},
  language     = {{eng}},
  month        = {{07}},
  number       = {{4}},
  pages        = {{699--704}},
  publisher    = {{Pacini}},
  series       = {{Clinical and Experimental Rheumatology}},
  title        = {{Antibodies to citrullinated peptides in serum and saliva in patients with rheumatoid arthritis and their association to periodontitis}},
  volume       = {{38}},
  year         = {{2020}},
}