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Detection of HPV mRNA in Self-collected Vaginal Samples Among Women at 69-70 Years of Age

Ernstson, Avalon LU orcid ; Asciutto, Katrin Christine LU ; Sturesson, Johan ; Norén, Jonas ; Forslund, Ola LU and Borgfeldt, Christer LU (2019) In Anticancer research 39(1). p.381-386
Abstract

BACKGROUND/AIM: Cervical cancer is associated with poorer diagnosis among the elderly and pap-smear screening has a lower sensitivity. Self-sampling for detection of high-risk human papillomavirus (hr-HPV) may be an alternative screening method. The aim of this study was to analyze the response rate to vaginal HPV self-sampling and the HPV mRNA prevalence among women 69-70 years. MATERIALS AND METHODS: An HPV self-sampling kit was sent to 1,000 women 69-70 years whom had not taken a cervical smear in ≥5 years. The samples were analyzed by the Aptima HPV mRNA assay. HPV-positive women were recalled for a follow-up examination. RESULTS: The self-sample response rate was 43.3%. The HPV mRNA prevalence was 6.2%. All HPV-positive women... (More)

BACKGROUND/AIM: Cervical cancer is associated with poorer diagnosis among the elderly and pap-smear screening has a lower sensitivity. Self-sampling for detection of high-risk human papillomavirus (hr-HPV) may be an alternative screening method. The aim of this study was to analyze the response rate to vaginal HPV self-sampling and the HPV mRNA prevalence among women 69-70 years. MATERIALS AND METHODS: An HPV self-sampling kit was sent to 1,000 women 69-70 years whom had not taken a cervical smear in ≥5 years. The samples were analyzed by the Aptima HPV mRNA assay. HPV-positive women were recalled for a follow-up examination. RESULTS: The self-sample response rate was 43.3%. The HPV mRNA prevalence was 6.2%. All HPV-positive women attended follow-up. CONCLUSION: HPV self-sampling was accepted among older women. Although the HPV mRNA prevalence was 6.2%, no high-grade cytological abnormalities were found. Larger studies are needed to elucidate hr-HPV self-sampling as a tool to identify older women at risk of cervical cancer.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cervical cancer, human papillomavirus, postmenopausal women, self-sampling
in
Anticancer research
volume
39
issue
1
pages
6 pages
publisher
International Institute of Cancer Research
external identifiers
  • scopus:85059227657
  • pmid:30591484
ISSN
1791-7530
DOI
10.21873/anticanres.13123
language
English
LU publication?
yes
id
e41977d2-910b-4115-9bf1-74ad97ddcaf4
date added to LUP
2019-01-11 09:10:12
date last changed
2025-10-14 10:12:40
@article{e41977d2-910b-4115-9bf1-74ad97ddcaf4,
  abstract     = {{<p>BACKGROUND/AIM: Cervical cancer is associated with poorer diagnosis among the elderly and pap-smear screening has a lower sensitivity. Self-sampling for detection of high-risk human papillomavirus (hr-HPV) may be an alternative screening method. The aim of this study was to analyze the response rate to vaginal HPV self-sampling and the HPV mRNA prevalence among women 69-70 years. MATERIALS AND METHODS: An HPV self-sampling kit was sent to 1,000 women 69-70 years whom had not taken a cervical smear in ≥5 years. The samples were analyzed by the Aptima HPV mRNA assay. HPV-positive women were recalled for a follow-up examination. RESULTS: The self-sample response rate was 43.3%. The HPV mRNA prevalence was 6.2%. All HPV-positive women attended follow-up. CONCLUSION: HPV self-sampling was accepted among older women. Although the HPV mRNA prevalence was 6.2%, no high-grade cytological abnormalities were found. Larger studies are needed to elucidate hr-HPV self-sampling as a tool to identify older women at risk of cervical cancer.</p>}},
  author       = {{Ernstson, Avalon and Asciutto, Katrin Christine and Sturesson, Johan and Norén, Jonas and Forslund, Ola and Borgfeldt, Christer}},
  issn         = {{1791-7530}},
  keywords     = {{Cervical cancer; human papillomavirus; postmenopausal women; self-sampling}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{381--386}},
  publisher    = {{International Institute of Cancer Research}},
  series       = {{Anticancer research}},
  title        = {{Detection of HPV mRNA in Self-collected Vaginal Samples Among Women at 69-70 Years of Age}},
  url          = {{http://dx.doi.org/10.21873/anticanres.13123}},
  doi          = {{10.21873/anticanres.13123}},
  volume       = {{39}},
  year         = {{2019}},
}