Ferroptosis in Parkinson's disease : glia–neuron crosstalk
(2022) In Trends in Molecular Medicine 28(4). p.258-269- Abstract
Parkinson's disease (PD) is characterized by dopaminergic (DA) neuron loss and the formation of cytoplasmic protein inclusions. Although the exact pathogenesis of PD is unknown, iron dyshomeostasis has been proposed as a potential contributing factor. Emerging evidence suggests that glial cell activation plays a pivotal role in ferroptosis and subsequent neurodegeneration. We review the association between iron deposition, glial activation, and neuronal death, and discuss whether and how ferroptosis affects α-synuclein aggregation and DA neuron loss. We examine the possible roles of different types of glia in mediating ferroptosis in neurons. Lastly, we review current PD clinical trials targeting iron homeostasis. Although clinical... (More)
Parkinson's disease (PD) is characterized by dopaminergic (DA) neuron loss and the formation of cytoplasmic protein inclusions. Although the exact pathogenesis of PD is unknown, iron dyshomeostasis has been proposed as a potential contributing factor. Emerging evidence suggests that glial cell activation plays a pivotal role in ferroptosis and subsequent neurodegeneration. We review the association between iron deposition, glial activation, and neuronal death, and discuss whether and how ferroptosis affects α-synuclein aggregation and DA neuron loss. We examine the possible roles of different types of glia in mediating ferroptosis in neurons. Lastly, we review current PD clinical trials targeting iron homeostasis. Although clinical trials are already evaluating ferroptosis modulation in PD, much remains unknown about metal ion metabolism and regulation in PD pathogenesis.
(Less)
- author
- Wang, Zhang Li ; Yuan, Lin ; Li, Wen LU and Li, Jia Yi LU
- organization
- publishing date
- 2022-04
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- ferroptosis, glia, iron, neuron, Parkinson's disease
- in
- Trends in Molecular Medicine
- volume
- 28
- issue
- 4
- pages
- 12 pages
- publisher
- Elsevier
- external identifiers
-
- pmid:35260343
- scopus:85125728384
- ISSN
- 1471-4914
- DOI
- 10.1016/j.molmed.2022.02.003
- language
- English
- LU publication?
- yes
- id
- e420c7fd-6120-4a74-818a-0a32085af111
- date added to LUP
- 2022-04-25 14:52:14
- date last changed
- 2024-04-18 07:42:20
@article{e420c7fd-6120-4a74-818a-0a32085af111,
abstract = {{<p>Parkinson's disease (PD) is characterized by dopaminergic (DA) neuron loss and the formation of cytoplasmic protein inclusions. Although the exact pathogenesis of PD is unknown, iron dyshomeostasis has been proposed as a potential contributing factor. Emerging evidence suggests that glial cell activation plays a pivotal role in ferroptosis and subsequent neurodegeneration. We review the association between iron deposition, glial activation, and neuronal death, and discuss whether and how ferroptosis affects α-synuclein aggregation and DA neuron loss. We examine the possible roles of different types of glia in mediating ferroptosis in neurons. Lastly, we review current PD clinical trials targeting iron homeostasis. Although clinical trials are already evaluating ferroptosis modulation in PD, much remains unknown about metal ion metabolism and regulation in PD pathogenesis.</p>}},
author = {{Wang, Zhang Li and Yuan, Lin and Li, Wen and Li, Jia Yi}},
issn = {{1471-4914}},
keywords = {{ferroptosis; glia; iron; neuron; Parkinson's disease}},
language = {{eng}},
number = {{4}},
pages = {{258--269}},
publisher = {{Elsevier}},
series = {{Trends in Molecular Medicine}},
title = {{Ferroptosis in Parkinson's disease : glia–neuron crosstalk}},
url = {{http://dx.doi.org/10.1016/j.molmed.2022.02.003}},
doi = {{10.1016/j.molmed.2022.02.003}},
volume = {{28}},
year = {{2022}},
}