Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

The vitamin D receptor (VDR) start codon polymorphism in primary hyperparathyroidism and parathyroid VDR messenger ribonucleic acid levels

Correa, P LU ; Rastad, J ; Schwarz, P ; Westin, G ; Kindmark, A ; Lundgren, Ewa ; Akerström, G and Carling, T (1999) In The Journal of clinical endocrinology and metabolism 84(5). p.4-1690
Abstract

Vitamin D regulates parathyroid cell proliferation and secretion of PTH. Increased prevalence of the polymorphic vitamin D receptor (VDR) alleles b, a, and T has been reported in sporadic primary hyperparathyroidism (PHPT), suggesting that these genetic variants may predispose to the disease. Recently, another polymorphism in the VDR gene was related to bone mineral density, and this VDR-FokI polymorphism causes different lengths of the VDR, implying possible functional consequences. The VDR-FokI polymorphism was studied in 182 postmenopausal women with sporadic PHPT and in matched controls. No significant differences in distribution of the VDR-FokI genotypes could be detected between the groups, although there was a tendency toward... (More)

Vitamin D regulates parathyroid cell proliferation and secretion of PTH. Increased prevalence of the polymorphic vitamin D receptor (VDR) alleles b, a, and T has been reported in sporadic primary hyperparathyroidism (PHPT), suggesting that these genetic variants may predispose to the disease. Recently, another polymorphism in the VDR gene was related to bone mineral density, and this VDR-FokI polymorphism causes different lengths of the VDR, implying possible functional consequences. The VDR-FokI polymorphism was studied in 182 postmenopausal women with sporadic PHPT and in matched controls. No significant differences in distribution of the VDR-FokI genotypes could be detected between the groups, although there was a tendency toward overrepresentation of the F allele in the PHPT patients (P = 0.05). There were no significant associations with age, serum calcium, serum PTH, bone mineral density, or parathyroid tumor weight. The VDR genotypes were unrelated to VDR and PTH messenger ribonucleic acid levels in the parathyroid adenomas of 42 PHPT patients. In 23 PHPT patients, the Ca2+-PTH set-points were determined in vivo and were unrelated to the VDR alleles. We suggest that the VDR-FokI polymorphism has at most a minor pathogenic importance in the development of PHPT.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adult, Aged, Aged, 80 and over, Calcium/blood, Citrates, Codon, Initiator/genetics, Deoxyribonucleases, Type II Site-Specific/biosynthesis, Female, Genotype, Humans, Hyperparathyroidism/genetics, Male, Middle Aged, Parathyroid Glands/metabolism, Parathyroid Hormone/biosynthesis, Polymorphism, Genetic, RNA, Messenger/biosynthesis, Receptors, Calcitriol/biosynthesis
in
The Journal of clinical endocrinology and metabolism
volume
84
issue
5
pages
4 - 1690
publisher
Oxford University Press
external identifiers
  • pmid:10323401
  • scopus:0033329304
ISSN
0021-972X
DOI
10.1210/jcem.84.5.5707
language
English
LU publication?
no
id
e4214934-d8a1-47d0-8ea8-24a06383019a
date added to LUP
2021-12-29 11:39:19
date last changed
2024-10-06 12:01:20
@article{e4214934-d8a1-47d0-8ea8-24a06383019a,
  abstract     = {{<p>Vitamin D regulates parathyroid cell proliferation and secretion of PTH. Increased prevalence of the polymorphic vitamin D receptor (VDR) alleles b, a, and T has been reported in sporadic primary hyperparathyroidism (PHPT), suggesting that these genetic variants may predispose to the disease. Recently, another polymorphism in the VDR gene was related to bone mineral density, and this VDR-FokI polymorphism causes different lengths of the VDR, implying possible functional consequences. The VDR-FokI polymorphism was studied in 182 postmenopausal women with sporadic PHPT and in matched controls. No significant differences in distribution of the VDR-FokI genotypes could be detected between the groups, although there was a tendency toward overrepresentation of the F allele in the PHPT patients (P = 0.05). There were no significant associations with age, serum calcium, serum PTH, bone mineral density, or parathyroid tumor weight. The VDR genotypes were unrelated to VDR and PTH messenger ribonucleic acid levels in the parathyroid adenomas of 42 PHPT patients. In 23 PHPT patients, the Ca2+-PTH set-points were determined in vivo and were unrelated to the VDR alleles. We suggest that the VDR-FokI polymorphism has at most a minor pathogenic importance in the development of PHPT.</p>}},
  author       = {{Correa, P and Rastad, J and Schwarz, P and Westin, G and Kindmark, A and Lundgren, Ewa and Akerström, G and Carling, T}},
  issn         = {{0021-972X}},
  keywords     = {{Adult; Aged; Aged, 80 and over; Calcium/blood; Citrates; Codon, Initiator/genetics; Deoxyribonucleases, Type II Site-Specific/biosynthesis; Female; Genotype; Humans; Hyperparathyroidism/genetics; Male; Middle Aged; Parathyroid Glands/metabolism; Parathyroid Hormone/biosynthesis; Polymorphism, Genetic; RNA, Messenger/biosynthesis; Receptors, Calcitriol/biosynthesis}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{4--1690}},
  publisher    = {{Oxford University Press}},
  series       = {{The Journal of clinical endocrinology and metabolism}},
  title        = {{The vitamin D receptor (VDR) start codon polymorphism in primary hyperparathyroidism and parathyroid VDR messenger ribonucleic acid levels}},
  url          = {{http://dx.doi.org/10.1210/jcem.84.5.5707}},
  doi          = {{10.1210/jcem.84.5.5707}},
  volume       = {{84}},
  year         = {{1999}},
}