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Opioid and amphetamine dependence is associated with methicillin-resistant Staphylococcus aureus (MRSA) : An epidemiological register study with 73,201 Swedish in- and outpatients 1997–2013

Dahlman, Disa LU ; Berge, Jonas LU ; Nilsson, Anna C. LU ; Kral, Alex H.; Björkman, Per LU and Håkansson, Anders C LU (2017) In Infectious Diseases 49(2). p.120-127
Abstract

Background: While methicillin-resistant Staphylococcus aureus (MRSA) is increasing in prevalence globally, Sweden is still a low-prevalence country enabling studies on the natural MRSA spread in subpopulations unaffected by a surrounding highly infected population. Substance dependence and injection drug use have been risk factors for MRSA carriage and infection in other countries. In this retrospective, longitudinal register study, we investigated MRSA epidemiology 1997–2013 in opioid and amphetamine-dependent individuals, in comparison with alcohol-dependent subjects. Methods: Data from the national Swedish in- and outpatients registers included 73,201 individuals from 1997, 1999, 2004, 2009 and 2013. We analyzed substance use... (More)

Background: While methicillin-resistant Staphylococcus aureus (MRSA) is increasing in prevalence globally, Sweden is still a low-prevalence country enabling studies on the natural MRSA spread in subpopulations unaffected by a surrounding highly infected population. Substance dependence and injection drug use have been risk factors for MRSA carriage and infection in other countries. In this retrospective, longitudinal register study, we investigated MRSA epidemiology 1997–2013 in opioid and amphetamine-dependent individuals, in comparison with alcohol-dependent subjects. Methods: Data from the national Swedish in- and outpatients registers included 73,201 individuals from 1997, 1999, 2004, 2009 and 2013. We analyzed substance use disorder and demographic predictors for MRSA using generalized estimating equations. Results: The main finding was that both opioid (adjusted odds ratio [AOR] = 2.82; 95% confidence interval [CI] = 2.16, 3.67) and amphetamine dependence (AOR = 2.71; 95% CI = 1.70, 4.16) were significantly associated with MRSA diagnosis compared with alcohol dependence, when adjusting for age, sex and year. Conclusions: These findings are of value to understand the dynamics of MRSA epidemiology among substance dependent persons with presumably low socioeconomic status and potential injection drug use, and implicate repeated surveillance of MRSA among these patients.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
epidemiology, Methicillin-resistance, people who inject drugs, Staphylococcus aureus, substance dependence
in
Infectious Diseases
volume
49
issue
2
pages
8 pages
publisher
Informa Healthcare
external identifiers
  • scopus:84990213862
  • wos:000393813100007
ISSN
2374-4243
DOI
10.1080/23744235.2016.1237038
language
English
LU publication?
yes
id
e473708e-782d-4f59-8942-40ad9b068c51
date added to LUP
2016-10-21 09:39:26
date last changed
2018-02-11 04:23:18
@article{e473708e-782d-4f59-8942-40ad9b068c51,
  abstract     = {<p>Background: While methicillin-resistant Staphylococcus aureus (MRSA) is increasing in prevalence globally, Sweden is still a low-prevalence country enabling studies on the natural MRSA spread in subpopulations unaffected by a surrounding highly infected population. Substance dependence and injection drug use have been risk factors for MRSA carriage and infection in other countries. In this retrospective, longitudinal register study, we investigated MRSA epidemiology 1997–2013 in opioid and amphetamine-dependent individuals, in comparison with alcohol-dependent subjects. Methods: Data from the national Swedish in- and outpatients registers included 73,201 individuals from 1997, 1999, 2004, 2009 and 2013. We analyzed substance use disorder and demographic predictors for MRSA using generalized estimating equations. Results: The main finding was that both opioid (adjusted odds ratio [AOR] = 2.82; 95% confidence interval [CI] = 2.16, 3.67) and amphetamine dependence (AOR = 2.71; 95% CI = 1.70, 4.16) were significantly associated with MRSA diagnosis compared with alcohol dependence, when adjusting for age, sex and year. Conclusions: These findings are of value to understand the dynamics of MRSA epidemiology among substance dependent persons with presumably low socioeconomic status and potential injection drug use, and implicate repeated surveillance of MRSA among these patients.</p>},
  author       = {Dahlman, Disa and Berge, Jonas and Nilsson, Anna C. and Kral, Alex H. and Björkman, Per and Håkansson, Anders C},
  issn         = {2374-4243},
  keyword      = {epidemiology,Methicillin-resistance,people who inject drugs,Staphylococcus aureus,substance dependence},
  language     = {eng},
  number       = {2},
  pages        = {120--127},
  publisher    = {Informa Healthcare},
  series       = {Infectious Diseases},
  title        = {Opioid and amphetamine dependence is associated with methicillin-resistant Staphylococcus aureus (MRSA) : An epidemiological register study with 73,201 Swedish in- and outpatients 1997–2013},
  url          = {http://dx.doi.org/10.1080/23744235.2016.1237038},
  volume       = {49},
  year         = {2017},
}