Molecularly Imprinted Polymers for Targeting Lipopolysaccharides and Photothermal Inactivation of Pseudomonas aeruginosa
(2023) In ACS Applied Polymer Materials 5(4). p.3055-3064- Abstract
- Although photothermal therapy is of significance in therapeutic strategies for fighting bacterial infection, the precise target of photothermal agents to bacterial sites is still a challenge. In this work, lipopolysaccharide (LPS) imprinted photothermal molecularly imprinted polymers (PMIP) were prepared for the efficient capture and elimination of Pseudomonas aeruginosa. The LPS derived from Pseudomonas aeruginosa was selected as a template due to its cis-diol structure, which can provide active sites to direct the boronate affinity-mediated synthesis of molecularly imprinted polymers. Polydopamine with good biocompatibility and photothermal effect was used as an imprinting matrix to achieve good photothermal function... (More)
- Although photothermal therapy is of significance in therapeutic strategies for fighting bacterial infection, the precise target of photothermal agents to bacterial sites is still a challenge. In this work, lipopolysaccharide (LPS) imprinted photothermal molecularly imprinted polymers (PMIP) were prepared for the efficient capture and elimination of Pseudomonas aeruginosa. The LPS derived from Pseudomonas aeruginosa was selected as a template due to its cis-diol structure, which can provide active sites to direct the boronate affinity-mediated synthesis of molecularly imprinted polymers. Polydopamine with good biocompatibility and photothermal effect was used as an imprinting matrix to achieve good photothermal function and imprinting efficiency. The combination of bacteria-imprinting with photothermal ability allowed PMIP to deactivate target bacteria with enhanced precision and efficiency. Taken together, our study offers a promising strategy to design synthetic materials for targeting and treating pathogens for various infectious diseases and expands the application of molecular imprinting technology in the field of antimicrobials. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/e4be2d17-16fe-4c18-ba7a-3054b4de5be9
- author
- Zhang, Qicheng LU ; Zhang, Ming ; Huang, Zheng ; Sun, Yi and Ye, Lei LU
- organization
- publishing date
- 2023-04-05
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Molecular imprinting, Boronate affinity, Lipopolysaccharide, Bacteria, Photothermal agent
- in
- ACS Applied Polymer Materials
- volume
- 5
- issue
- 4
- pages
- 10 pages
- publisher
- The American Chemical Society (ACS)
- external identifiers
-
- scopus:85152200521
- ISSN
- 2637-6105
- DOI
- 10.1021/acsapm.3c00204
- language
- English
- LU publication?
- yes
- id
- e4be2d17-16fe-4c18-ba7a-3054b4de5be9
- date added to LUP
- 2023-05-11 13:48:04
- date last changed
- 2023-05-12 12:43:57
@article{e4be2d17-16fe-4c18-ba7a-3054b4de5be9, abstract = {{Although photothermal therapy is of significance in therapeutic strategies for fighting bacterial infection, the precise target of photothermal agents to bacterial sites is still a challenge. In this work, lipopolysaccharide (LPS) imprinted photothermal molecularly imprinted polymers (PMIP) were prepared for the efficient capture and elimination of <i>Pseudomonas aeruginosa</i>. The LPS derived from <i>Pseudomonas aeruginosa</i> was selected as a template due to its <i>cis</i>-diol structure, which can provide active sites to direct the boronate affinity-mediated synthesis of molecularly imprinted polymers. Polydopamine with good biocompatibility and photothermal effect was used as an imprinting matrix to achieve good photothermal function and imprinting efficiency. The combination of bacteria-imprinting with photothermal ability allowed PMIP to deactivate target bacteria with enhanced precision and efficiency. Taken together, our study offers a promising strategy to design synthetic materials for targeting and treating pathogens for various infectious diseases and expands the application of molecular imprinting technology in the field of antimicrobials.}}, author = {{Zhang, Qicheng and Zhang, Ming and Huang, Zheng and Sun, Yi and Ye, Lei}}, issn = {{2637-6105}}, keywords = {{Molecular imprinting; Boronate affinity; Lipopolysaccharide; Bacteria; Photothermal agent}}, language = {{eng}}, month = {{04}}, number = {{4}}, pages = {{3055--3064}}, publisher = {{The American Chemical Society (ACS)}}, series = {{ACS Applied Polymer Materials}}, title = {{Molecularly Imprinted Polymers for Targeting Lipopolysaccharides and Photothermal Inactivation of <i>Pseudomonas aeruginosa</i>}}, url = {{http://dx.doi.org/10.1021/acsapm.3c00204}}, doi = {{10.1021/acsapm.3c00204}}, volume = {{5}}, year = {{2023}}, }