Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Molecularly Imprinted Polymers for Targeting Lipopolysaccharides and Photothermal Inactivation of Pseudomonas aeruginosa

Zhang, Qicheng LU ; Zhang, Ming ; Huang, Zheng ; Sun, Yi and Ye, Lei LU orcid (2023) In ACS Applied Polymer Materials 5(4). p.3055-3064
Abstract
Although photothermal therapy is of significance in therapeutic strategies for fighting bacterial infection, the precise target of photothermal agents to bacterial sites is still a challenge. In this work, lipopolysaccharide (LPS) imprinted photothermal molecularly imprinted polymers (PMIP) were prepared for the efficient capture and elimination of Pseudomonas aeruginosa. The LPS derived from Pseudomonas aeruginosa was selected as a template due to its cis-diol structure, which can provide active sites to direct the boronate affinity-mediated synthesis of molecularly imprinted polymers. Polydopamine with good biocompatibility and photothermal effect was used as an imprinting matrix to achieve good photothermal function... (More)
Although photothermal therapy is of significance in therapeutic strategies for fighting bacterial infection, the precise target of photothermal agents to bacterial sites is still a challenge. In this work, lipopolysaccharide (LPS) imprinted photothermal molecularly imprinted polymers (PMIP) were prepared for the efficient capture and elimination of Pseudomonas aeruginosa. The LPS derived from Pseudomonas aeruginosa was selected as a template due to its cis-diol structure, which can provide active sites to direct the boronate affinity-mediated synthesis of molecularly imprinted polymers. Polydopamine with good biocompatibility and photothermal effect was used as an imprinting matrix to achieve good photothermal function and imprinting efficiency. The combination of bacteria-imprinting with photothermal ability allowed PMIP to deactivate target bacteria with enhanced precision and efficiency. Taken together, our study offers a promising strategy to design synthetic materials for targeting and treating pathogens for various infectious diseases and expands the application of molecular imprinting technology in the field of antimicrobials. (Less)
Please use this url to cite or link to this publication:
author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Molecular imprinting, Boronate affinity, Lipopolysaccharide, Bacteria, Photothermal agent
in
ACS Applied Polymer Materials
volume
5
issue
4
pages
10 pages
publisher
The American Chemical Society (ACS)
external identifiers
  • scopus:85152200521
ISSN
2637-6105
DOI
10.1021/acsapm.3c00204
language
English
LU publication?
yes
id
e4be2d17-16fe-4c18-ba7a-3054b4de5be9
date added to LUP
2023-05-11 13:48:04
date last changed
2023-05-12 12:43:57
@article{e4be2d17-16fe-4c18-ba7a-3054b4de5be9,
  abstract     = {{Although photothermal therapy is of significance in therapeutic strategies for fighting bacterial infection, the precise target of photothermal agents to bacterial sites is still a challenge. In this work, lipopolysaccharide (LPS) imprinted photothermal molecularly imprinted polymers (PMIP) were prepared for the efficient capture and elimination of <i>Pseudomonas aeruginosa</i>. The LPS derived from <i>Pseudomonas aeruginosa</i> was selected as a template due to its <i>cis</i>-diol structure, which can provide active sites to direct the boronate affinity-mediated synthesis of molecularly imprinted polymers. Polydopamine with good biocompatibility and photothermal effect was used as an imprinting matrix to achieve good photothermal function and imprinting efficiency. The combination of bacteria-imprinting with photothermal ability allowed PMIP to deactivate target bacteria with enhanced precision and efficiency. Taken together, our study offers a promising strategy to design synthetic materials for targeting and treating pathogens for various infectious diseases and expands the application of molecular imprinting technology in the field of antimicrobials.}},
  author       = {{Zhang, Qicheng and Zhang, Ming and Huang, Zheng and Sun, Yi and Ye, Lei}},
  issn         = {{2637-6105}},
  keywords     = {{Molecular imprinting; Boronate affinity; Lipopolysaccharide; Bacteria; Photothermal agent}},
  language     = {{eng}},
  month        = {{04}},
  number       = {{4}},
  pages        = {{3055--3064}},
  publisher    = {{The American Chemical Society (ACS)}},
  series       = {{ACS Applied Polymer Materials}},
  title        = {{Molecularly Imprinted Polymers for Targeting Lipopolysaccharides and Photothermal Inactivation of <i>Pseudomonas aeruginosa</i>}},
  url          = {{http://dx.doi.org/10.1021/acsapm.3c00204}},
  doi          = {{10.1021/acsapm.3c00204}},
  volume       = {{5}},
  year         = {{2023}},
}