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Seleno protein-P deficiency predicts cardiovascular disease and death

Schomburg, Lutz ; Orho-Melander, Marju LU ; Struck, Joachim ; Bergmann, Andreas and Melander, Olle LU (2019) In Nutrients 11(8).
Abstract

Selenoprotein-P (SELENOP) is the main carrier of selenium to target organs and reduces tissue oxidative stress both directly and by delivering selenium to protective selenoproteins. We tested if the plasma concentration of SELENOP predicts cardiovascular morbidity and mortality in the primary preventive setting. SELENOP was measured from the baseline exam in 2002–2006 of the Malmö Preventive Project, a population-based prospective cohort study, using a validated ELISA. Quintiles of SELENOP concentration were related to the risk of all-cause mortality, cardiovascular mortality, and a first cardiovascular event in 4366 subjects during a median (interquartile range) follow-up time of 9.3 (8.3–11) years using Cox proportional Hazards Model... (More)

Selenoprotein-P (SELENOP) is the main carrier of selenium to target organs and reduces tissue oxidative stress both directly and by delivering selenium to protective selenoproteins. We tested if the plasma concentration of SELENOP predicts cardiovascular morbidity and mortality in the primary preventive setting. SELENOP was measured from the baseline exam in 2002–2006 of the Malmö Preventive Project, a population-based prospective cohort study, using a validated ELISA. Quintiles of SELENOP concentration were related to the risk of all-cause mortality, cardiovascular mortality, and a first cardiovascular event in 4366 subjects during a median (interquartile range) follow-up time of 9.3 (8.3–11) years using Cox proportional Hazards Model adjusting for cardiovascular risk factors. Compared to subjects in the lowest quintile of SELENOP, the risk of all three endpoints was significantly lower in quintiles 2–5. The risk (multivariate adjusted hazard ratio, 95% CI) decreased gradually with the lowest risk in quintile 4 for all-cause mortality (0.57, 0.48–0.69) (p < 0.001), cardiovascular mortality (0.52, 0.37–0.72) (p < 0.001), and first cardiovascular event (0.56, 0.44–0.71) (p < 0.001). The lower risk of a first cardiovascular event in quintiles 2–5 as compared to quintile 1 was significant for both coronary artery disease and stroke. We conclude that the 20% with lowest SELENOP concentrations in a North European population without history of cardiovascular disease have markedly increased risk of cardiovascular morbidity and mortality, and preventive selenium supplementation studies stratified for these subjects are warranted.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cardiovascular disease, Prevention, Selenium, Selenoprotein-P, Supplementation
in
Nutrients
volume
11
issue
8
article number
1852
publisher
MDPI AG
external identifiers
  • scopus:85071149965
  • pmid:31404994
ISSN
2072-6643
DOI
10.3390/nu11081852
language
English
LU publication?
yes
id
e4e04c55-2783-427d-8396-a3ed72b44f0b
date added to LUP
2019-09-09 10:04:20
date last changed
2019-09-26 04:41:45
@article{e4e04c55-2783-427d-8396-a3ed72b44f0b,
  abstract     = {<p>Selenoprotein-P (SELENOP) is the main carrier of selenium to target organs and reduces tissue oxidative stress both directly and by delivering selenium to protective selenoproteins. We tested if the plasma concentration of SELENOP predicts cardiovascular morbidity and mortality in the primary preventive setting. SELENOP was measured from the baseline exam in 2002–2006 of the Malmö Preventive Project, a population-based prospective cohort study, using a validated ELISA. Quintiles of SELENOP concentration were related to the risk of all-cause mortality, cardiovascular mortality, and a first cardiovascular event in 4366 subjects during a median (interquartile range) follow-up time of 9.3 (8.3–11) years using Cox proportional Hazards Model adjusting for cardiovascular risk factors. Compared to subjects in the lowest quintile of SELENOP, the risk of all three endpoints was significantly lower in quintiles 2–5. The risk (multivariate adjusted hazard ratio, 95% CI) decreased gradually with the lowest risk in quintile 4 for all-cause mortality (0.57, 0.48–0.69) (p &lt; 0.001), cardiovascular mortality (0.52, 0.37–0.72) (p &lt; 0.001), and first cardiovascular event (0.56, 0.44–0.71) (p &lt; 0.001). The lower risk of a first cardiovascular event in quintiles 2–5 as compared to quintile 1 was significant for both coronary artery disease and stroke. We conclude that the 20% with lowest SELENOP concentrations in a North European population without history of cardiovascular disease have markedly increased risk of cardiovascular morbidity and mortality, and preventive selenium supplementation studies stratified for these subjects are warranted.</p>},
  author       = {Schomburg, Lutz and Orho-Melander, Marju and Struck, Joachim and Bergmann, Andreas and Melander, Olle},
  issn         = {2072-6643},
  language     = {eng},
  month        = {08},
  number       = {8},
  publisher    = {MDPI AG},
  series       = {Nutrients},
  title        = {Seleno protein-P deficiency predicts cardiovascular disease and death},
  url          = {http://dx.doi.org/10.3390/nu11081852},
  doi          = {10.3390/nu11081852},
  volume       = {11},
  year         = {2019},
}