Cost-effectiveness of maintenance rituximab treatment after second line therapy in patients with follicular lymphoma in Sweden
(2008) In Acta Oncologica 47(6). p.1029-1036- Abstract
- Introduction. Rituximab has significantly improved the prognosis for patients with both indolent and aggressive non-Hodgkin's lymphoma. An economic evaluation was carried out to assess the cost-effectiveness in Sweden of rituximab as maintenance therapy for patients with follicular lymphoma in remission after second line therapy. Materials and methods. The incremental cost and effectiveness of rituximab maintenance therapy versus observation were evaluated in a health-state transition model. Primary effect measures were quality-adjusted life-years (QALY) and life-years gained (LYG). Model state transitions were calculated based on progression-free and overall survival data from the EORTC20981 trial. The analysis was made from the... (More)
- Introduction. Rituximab has significantly improved the prognosis for patients with both indolent and aggressive non-Hodgkin's lymphoma. An economic evaluation was carried out to assess the cost-effectiveness in Sweden of rituximab as maintenance therapy for patients with follicular lymphoma in remission after second line therapy. Materials and methods. The incremental cost and effectiveness of rituximab maintenance therapy versus observation were evaluated in a health-state transition model. Primary effect measures were quality-adjusted life-years (QALY) and life-years gained (LYG). Model state transitions were calculated based on progression-free and overall survival data from the EORTC20981 trial. The analysis was made from the perspective of the healthcare provider, including direct medical costs presented in (sic), 2007 value. Effects and costs were discounted at a 3% annual rate. The stability of the base case results were tested in one-way and probabilistic sensitivity analyses. Results. The evaluation assessed rituximab maintenance therapy to be associated with an incremental cost per QALY gained of (sic)12 600 and an incremental cost per LYG of (sic)11 200. The average discounted life expectancy for patients on rituximab maintenance was 1.0 year longer than for patients on observation (5.96 vs. 4.94 years). Rituximab maintenance was associated with an additional 0.9 QALY, and total costs per patient were (sic)11 500 higher in the treatment arm, compared to observation. Discussion. The results indicate that rituximab maintenance treatment after successful induction therapy for patients with relapsed/refractory follicular lymphoma in Sweden is cost-effective compared to observation. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1247878
- author
- Kasteng, Frida ; Erlanson, Martin ; Hagberg, Hans ; Kimby, Eva ; Relander, Thomas LU and Lundkvist, Jonas
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Acta Oncologica
- volume
- 47
- issue
- 6
- pages
- 1029 - 1036
- publisher
- Taylor & Francis
- external identifiers
-
- wos:000258905100006
- scopus:51149091885
- pmid:18607857
- ISSN
- 1651-226X
- DOI
- 10.1080/02841860802120028
- language
- English
- LU publication?
- yes
- id
- e554a411-231f-4678-8f46-de0e0d7baea8 (old id 1247878)
- date added to LUP
- 2016-04-01 13:44:47
- date last changed
- 2022-02-26 22:53:25
@article{e554a411-231f-4678-8f46-de0e0d7baea8,
abstract = {{Introduction. Rituximab has significantly improved the prognosis for patients with both indolent and aggressive non-Hodgkin's lymphoma. An economic evaluation was carried out to assess the cost-effectiveness in Sweden of rituximab as maintenance therapy for patients with follicular lymphoma in remission after second line therapy. Materials and methods. The incremental cost and effectiveness of rituximab maintenance therapy versus observation were evaluated in a health-state transition model. Primary effect measures were quality-adjusted life-years (QALY) and life-years gained (LYG). Model state transitions were calculated based on progression-free and overall survival data from the EORTC20981 trial. The analysis was made from the perspective of the healthcare provider, including direct medical costs presented in (sic), 2007 value. Effects and costs were discounted at a 3% annual rate. The stability of the base case results were tested in one-way and probabilistic sensitivity analyses. Results. The evaluation assessed rituximab maintenance therapy to be associated with an incremental cost per QALY gained of (sic)12 600 and an incremental cost per LYG of (sic)11 200. The average discounted life expectancy for patients on rituximab maintenance was 1.0 year longer than for patients on observation (5.96 vs. 4.94 years). Rituximab maintenance was associated with an additional 0.9 QALY, and total costs per patient were (sic)11 500 higher in the treatment arm, compared to observation. Discussion. The results indicate that rituximab maintenance treatment after successful induction therapy for patients with relapsed/refractory follicular lymphoma in Sweden is cost-effective compared to observation.}},
author = {{Kasteng, Frida and Erlanson, Martin and Hagberg, Hans and Kimby, Eva and Relander, Thomas and Lundkvist, Jonas}},
issn = {{1651-226X}},
language = {{eng}},
number = {{6}},
pages = {{1029--1036}},
publisher = {{Taylor & Francis}},
series = {{Acta Oncologica}},
title = {{Cost-effectiveness of maintenance rituximab treatment after second line therapy in patients with follicular lymphoma in Sweden}},
url = {{http://dx.doi.org/10.1080/02841860802120028}},
doi = {{10.1080/02841860802120028}},
volume = {{47}},
year = {{2008}},
}