Multi-Infection Patterns and Co-infection Preference of 27 Human Papillomavirus Types Among 137,943 Gynecological Outpatients Across China
(2020) In Frontiers in Oncology 10.- Abstract
Background: The epidemiological feature of human papillomavirus (HPV) infection is distinctive in China. We aimed to investigate the multi-infection patterns and co-infection preference of 27 HPV types among gynecological outpatients across China. Methods: Overall 137,943 gynecological outpatients were recruited from eight tertiary hospitals located in seven regions of China, between July 1st, 2014 and December 31st, 2016. The overall, region-specific, age-specific and type-specific prevalence of HPV infection were calculated, respectively. The pattern of HPV infection was also evaluated. Furthermore, rate ratio was calculated to evaluate the co-infection preference of any two HPV genotypes. Results: The overall prevalence of 27 HPVs'... (More)
Background: The epidemiological feature of human papillomavirus (HPV) infection is distinctive in China. We aimed to investigate the multi-infection patterns and co-infection preference of 27 HPV types among gynecological outpatients across China. Methods: Overall 137,943 gynecological outpatients were recruited from eight tertiary hospitals located in seven regions of China, between July 1st, 2014 and December 31st, 2016. The overall, region-specific, age-specific and type-specific prevalence of HPV infection were calculated, respectively. The pattern of HPV infection was also evaluated. Furthermore, rate ratio was calculated to evaluate the co-infection preference of any two HPV genotypes. Results: The overall prevalence of 27 HPVs' [17 high-risk (hr)/10 low-risk (lr)] infection was 23.5%. The age-specific HPV prevalence showed a "U-shaped" pattern. The most prevalent hrHPV genotypes were 16, 52, and 58. Multiple infections were detected in 25.8% of the HPV-positive women, in which dual infection was more prevalent. HPV 16/18 were likely to co-infected with HPV 31 but unlikely with HPV 52/58, i.e., the co-infection of HPV 16 with HPV 31 was high (3.5-fold), but low for HPV 58 (1.8-fold), and 52 (1.2-fold), while the co-infection of HPV 18 with HPV 31 was high (4.3-fold), but low for HPV 52 (1.9-fold), and 58 (1.7-fold). Conclusions: We found age-specific prevalence of HPV infection showed a "U-shaped" pattern for high and low risk HPV, suggesting the importance of screening among younger women and the necessary of detection among older women. We found a novel co-infection preference of HPV 16/18 with 31, 52, and 58, suggesting a need of developing and marketing prophylactic HPV vaccines that protect against more genotypes in China.
(Less)
- author
- Liao, Guangdong
; Jiang, Xiyi
; She, Bin
; Tang, Huijuan
; Wang, Zhongyong
; Zhou, Hongrong
; Ma, Yan
; Xu, Weidong
; Xu, Hongxing
; Chen, Wen
; Ji, Jianguang
LU
; Xi, Mingrong
and Chen, Tianhui
(Less) - organization
- publishing date
- 2020-04-07
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Frontiers in Oncology
- volume
- 10
- article number
- 449
- publisher
- Frontiers Media S. A.
- external identifiers
-
- scopus:85083507653
- pmid:32318343
- ISSN
- 2234-943X
- DOI
- 10.3389/fonc.2020.00449
- language
- English
- LU publication?
- yes
- additional info
- Copyright © 2020 Liao, Jiang, She, Tang, Wang, Zhou, Ma, Xu, Xu, Chen, Ji, Xi and Chen.
- id
- e580fbca-5578-4898-8356-af5df9c2201a
- date added to LUP
- 2020-05-04 11:09:10
- date last changed
- 2024-04-17 07:44:09
@article{e580fbca-5578-4898-8356-af5df9c2201a,
abstract = {{<p>Background: The epidemiological feature of human papillomavirus (HPV) infection is distinctive in China. We aimed to investigate the multi-infection patterns and co-infection preference of 27 HPV types among gynecological outpatients across China. Methods: Overall 137,943 gynecological outpatients were recruited from eight tertiary hospitals located in seven regions of China, between July 1st, 2014 and December 31st, 2016. The overall, region-specific, age-specific and type-specific prevalence of HPV infection were calculated, respectively. The pattern of HPV infection was also evaluated. Furthermore, rate ratio was calculated to evaluate the co-infection preference of any two HPV genotypes. Results: The overall prevalence of 27 HPVs' [17 high-risk (hr)/10 low-risk (lr)] infection was 23.5%. The age-specific HPV prevalence showed a "U-shaped" pattern. The most prevalent hrHPV genotypes were 16, 52, and 58. Multiple infections were detected in 25.8% of the HPV-positive women, in which dual infection was more prevalent. HPV 16/18 were likely to co-infected with HPV 31 but unlikely with HPV 52/58, i.e., the co-infection of HPV 16 with HPV 31 was high (3.5-fold), but low for HPV 58 (1.8-fold), and 52 (1.2-fold), while the co-infection of HPV 18 with HPV 31 was high (4.3-fold), but low for HPV 52 (1.9-fold), and 58 (1.7-fold). Conclusions: We found age-specific prevalence of HPV infection showed a "U-shaped" pattern for high and low risk HPV, suggesting the importance of screening among younger women and the necessary of detection among older women. We found a novel co-infection preference of HPV 16/18 with 31, 52, and 58, suggesting a need of developing and marketing prophylactic HPV vaccines that protect against more genotypes in China.</p>}},
author = {{Liao, Guangdong and Jiang, Xiyi and She, Bin and Tang, Huijuan and Wang, Zhongyong and Zhou, Hongrong and Ma, Yan and Xu, Weidong and Xu, Hongxing and Chen, Wen and Ji, Jianguang and Xi, Mingrong and Chen, Tianhui}},
issn = {{2234-943X}},
language = {{eng}},
month = {{04}},
publisher = {{Frontiers Media S. A.}},
series = {{Frontiers in Oncology}},
title = {{Multi-Infection Patterns and Co-infection Preference of 27 Human Papillomavirus Types Among 137,943 Gynecological Outpatients Across China}},
url = {{http://dx.doi.org/10.3389/fonc.2020.00449}},
doi = {{10.3389/fonc.2020.00449}},
volume = {{10}},
year = {{2020}},
}