Sealing of submicrometer wells by a shear-driven lipid bilayer
(2010) In Nano Letters 10(5). p.6-1900- Abstract
A supported lipid bilayer (SLB) was formed in a microfluidic channel by vesicle fusion. The SLB, formed on a flat part of the surface, was driven by the shear forces of a bulk flow above the SLB to a part of the surface with embedded submicrometer wells. When using a bulk solution with a pH of 9.5 the advancing lipid bilayer sealed the wells, creating free-spanning membranes, whereas at a pH of 8.0 the SLB instead followed the contour of the wells.
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https://lup.lub.lu.se/record/e5988692-2037-4c66-85f2-680e8fc6585b
- author
- Jönsson, Peter LU ; Jonsson, Magnus P LU and Höök, Fredrik LU
- publishing date
- 2010-05-12
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Lipid Bilayers, Macromolecular Substances, Materials Testing, Microfluidics, Molecular Conformation, Nanostructures, Nanotechnology, Particle Size, Shear Strength, Surface Properties, Journal Article, Research Support, Non-U.S. Gov't
- in
- Nano Letters
- volume
- 10
- issue
- 5
- pages
- 7 pages
- publisher
- The American Chemical Society (ACS)
- external identifiers
-
- pmid:20405904
- scopus:77952357781
- ISSN
- 1530-6992
- DOI
- 10.1021/nl100779k
- language
- English
- LU publication?
- no
- id
- e5988692-2037-4c66-85f2-680e8fc6585b
- date added to LUP
- 2018-01-26 10:48:35
- date last changed
- 2024-09-16 16:19:33
@article{e5988692-2037-4c66-85f2-680e8fc6585b, abstract = {{<p>A supported lipid bilayer (SLB) was formed in a microfluidic channel by vesicle fusion. The SLB, formed on a flat part of the surface, was driven by the shear forces of a bulk flow above the SLB to a part of the surface with embedded submicrometer wells. When using a bulk solution with a pH of 9.5 the advancing lipid bilayer sealed the wells, creating free-spanning membranes, whereas at a pH of 8.0 the SLB instead followed the contour of the wells.</p>}}, author = {{Jönsson, Peter and Jonsson, Magnus P and Höök, Fredrik}}, issn = {{1530-6992}}, keywords = {{Lipid Bilayers; Macromolecular Substances; Materials Testing; Microfluidics; Molecular Conformation; Nanostructures; Nanotechnology; Particle Size; Shear Strength; Surface Properties; Journal Article; Research Support, Non-U.S. Gov't}}, language = {{eng}}, month = {{05}}, number = {{5}}, pages = {{6--1900}}, publisher = {{The American Chemical Society (ACS)}}, series = {{Nano Letters}}, title = {{Sealing of submicrometer wells by a shear-driven lipid bilayer}}, url = {{http://dx.doi.org/10.1021/nl100779k}}, doi = {{10.1021/nl100779k}}, volume = {{10}}, year = {{2010}}, }