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Sealing of submicrometer wells by a shear-driven lipid bilayer

Jönsson, Peter LU orcid ; Jonsson, Magnus P LU and Höök, Fredrik LU (2010) In Nano Letters 10(5). p.6-1900
Abstract

A supported lipid bilayer (SLB) was formed in a microfluidic channel by vesicle fusion. The SLB, formed on a flat part of the surface, was driven by the shear forces of a bulk flow above the SLB to a part of the surface with embedded submicrometer wells. When using a bulk solution with a pH of 9.5 the advancing lipid bilayer sealed the wells, creating free-spanning membranes, whereas at a pH of 8.0 the SLB instead followed the contour of the wells.

Please use this url to cite or link to this publication:
author
; and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Lipid Bilayers, Macromolecular Substances, Materials Testing, Microfluidics, Molecular Conformation, Nanostructures, Nanotechnology, Particle Size, Shear Strength, Surface Properties, Journal Article, Research Support, Non-U.S. Gov't
in
Nano Letters
volume
10
issue
5
pages
7 pages
publisher
The American Chemical Society (ACS)
external identifiers
  • scopus:77952357781
  • pmid:20405904
ISSN
1530-6992
DOI
10.1021/nl100779k
language
English
LU publication?
no
id
e5988692-2037-4c66-85f2-680e8fc6585b
date added to LUP
2018-01-26 10:48:35
date last changed
2025-10-14 11:21:49
@article{e5988692-2037-4c66-85f2-680e8fc6585b,
  abstract     = {{<p>A supported lipid bilayer (SLB) was formed in a microfluidic channel by vesicle fusion. The SLB, formed on a flat part of the surface, was driven by the shear forces of a bulk flow above the SLB to a part of the surface with embedded submicrometer wells. When using a bulk solution with a pH of 9.5 the advancing lipid bilayer sealed the wells, creating free-spanning membranes, whereas at a pH of 8.0 the SLB instead followed the contour of the wells.</p>}},
  author       = {{Jönsson, Peter and Jonsson, Magnus P and Höök, Fredrik}},
  issn         = {{1530-6992}},
  keywords     = {{Lipid Bilayers; Macromolecular Substances; Materials Testing; Microfluidics; Molecular Conformation; Nanostructures; Nanotechnology; Particle Size; Shear Strength; Surface Properties; Journal Article; Research Support, Non-U.S. Gov't}},
  language     = {{eng}},
  month        = {{05}},
  number       = {{5}},
  pages        = {{6--1900}},
  publisher    = {{The American Chemical Society (ACS)}},
  series       = {{Nano Letters}},
  title        = {{Sealing of submicrometer wells by a shear-driven lipid bilayer}},
  url          = {{http://dx.doi.org/10.1021/nl100779k}},
  doi          = {{10.1021/nl100779k}},
  volume       = {{10}},
  year         = {{2010}},
}